X0304 4 2012-03-13 0 0000861838 IDERA PHARMACEUTICALS, INC. IDRA 0001085605 AGRAWAL SUDHIR C/O IDERA PHARMACEUTICALS, INC. 167 SIDNEY STREET CAMBRIDGE MA 02139 1 1 0 0 Chairman, CEO & President Stock Option (Right to Buy) 1.157 2012-03-13 4 A 0 31250 0.00 A 2021-11-28 Common Stock 31250 281250 D Stock Option (Right to Buy) 1.16 2012-03-13 4 A 0 2188 0.00 A 2021-11-28 Common Stock 2188 19688 D On December 5, 2011, the reporting person was granted an option to purchase up to an aggregate of 500,000 shares of common stock. Half of the shares subject to such option are subject to satisfaction of performance vesting criteria. On March 13, 2012, certain performance vesting criteria were met with respect to 31,250 of such shares, of which 7,812 shares vested on March 13, 2012 and the remaining 23,438 of which will vest in three equal annual installments beginning on March 13, 2013. On January 3, 2012, the reporting person was granted an option to purchase up to an aggregate of 35,000 shares of common stock. Half of the shares subject to such option are subject to satisfaction of performance vesting criteria. On March 13, 2012, certain performance vesting criteria were met with respect to 2,188 of such shares, of which 547 shares vested on March 13, 2012 and the remaining 1,641 of which will vest in three equal annual installments beginning on March 13, 2013. /s/ Sudhir Agrawal 2012-03-15