X0306 4 2016-01-06 0 0000861838 IDERA PHARMACEUTICALS, INC. IDRA 0001085605 AGRAWAL SUDHIR C/O IDERA PHARMACEUTICALS, INC. 167 SIDNEY STREET CAMBRIDGE MA 02139 1 1 0 0 President of Research Stock Option 2.88 2016-01-06 4 A 0 231250 0 A 2026-01-06 Common Stock 231250 231250 D This option was granted under the Company's 2013 Stock Incentive Plan. The option vests with respect to 25% of the underlying shares on the first anniversary of the date of grant and the balance of the underlying shares vest in twelve equal quarterly installments following the first anniversary of the date of grant. /s/ Sudhir Agrawal 2016-01-07