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Note 3 - Intangible Assets - Summary of Intangible Assets (Details) - USD ($)
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Gross carrying amount $ 526,146 $ 526,177
Accumulated amortization (149,740) (174,991)
Aggregate amoritization expense 24,749 25,919
Patents [Member]    
Gross carrying amount 526,146 476,177
Accumulated amortization (149,740) (126,032)
Licensing Agreements [Member]    
Gross carrying amount 50,000
Accumulated amortization $ (48,959)