X0609 4 2026-06-18 false 0001082554 UNITED THERAPEUTICS Corp UTHR 0001636178 EDGEMOND JAMES false C/O UNITED THERAPEUTICS CORPORATION 1000 SPRING STREET SILVER SPRING MD 20910 false true false false CFO AND TREASURER true Common Stock 2026-06-18 4 M false 10000.00 146.03 A 28876.00 D Common Stock 2026-06-18 4 S false 400.00 533.587 D 28476.00 D Common Stock 2026-06-18 4 S false 160.00 534.475 D 28316.00 D Common Stock 2026-06-18 4 S false 210.00 536.2721 D 28106.00 D Common Stock 2026-06-18 4 S false 600.00 537.2397 D 27506.00 D Common Stock 2026-06-18 4 S false 1440.00 538.3079 D 26066.00 D Common Stock 2026-06-18 4 S false 2035.00 539.4173 D 24031.00 D Common Stock 2026-06-18 4 S false 2978.00 540.2175 D 21053.00 D Common Stock 2026-06-18 4 S false 865.00 541.0582 D 20188.00 D Common Stock 2026-06-18 4 S false 192.00 541.8846 D 19996.00 D Common Stock 2026-06-18 4 S false 40.00 543.5268 D 19956.00 D Common Stock 2026-06-18 4 S false 40.00 545.19 D 19916.00 D Common Stock 2026-06-18 4 S false 265.00 547.3683 D 19651.00 D Common Stock 2026-06-18 4 S false 115.00 547.8052 D 19536.00 D Common Stock 2026-06-18 4 S false 660.00 548.9021 D 18876.00 D Stock Option 146.03 2026-06-18 4 M false 10000.00 0.00 D 2020-03-15 2027-03-15 Common Stock 10000.00 8750.00 D This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on October 31, 2025. This transaction was executed in multiple trades at prices ranging from $541.82 to $542.04. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $543.37 to $543.56. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $546.69 to $547.545. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $547.69 to $548.37. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $548.69 to $549.17. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $533.25 to $533.66. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $534.39 to $534.70. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $535.73 to $536.58. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $536.76 to $537.48. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $537.78 to $538.77. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $538.78 to $539.76. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $539.78 to $540.75. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $540.78 to $541.61. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. /s/ John S. Hess, Jr. under Power of Attorney 2026-06-22