X0508 4 2025-11-24 false 0001082554 UNITED THERAPEUTICS Corp UTHR 0001636178 EDGEMOND JAMES C/O UNITED THERAPEUTICS CORPORATION 1000 SPRING STREET SILVER SPRING MD 20910 false true false false CFO AND TREASURER true Common Stock 2025-11-24 4 M false 21000.00 146.03 A 29142.00 D Common Stock 2025-11-24 4 S false 960.00 467.3519 D 28182.00 D Common Stock 2025-11-24 4 S false 1850.00 468.2863 D 26332.00 D Common Stock 2025-11-24 4 S false 1552.00 469.3386 D 24780.00 D Common Stock 2025-11-24 4 S false 2919.00 470.2208 D 21861.00 D Common Stock 2025-11-24 4 S false 1971.00 471.8802 D 19890.00 D Common Stock 2025-11-24 4 S false 1788.00 472.7256 D 18102.00 D Common Stock 2025-11-24 4 S false 280.00 473.5446 D 17822.00 D Common Stock 2025-11-24 4 S false 1560.00 475.1074 D 16262.00 D Common Stock 2025-11-24 4 S false 1621.00 476.0921 D 14641.00 D Common Stock 2025-11-24 4 S false 2989.00 477.2173 D 11652.00 D Common Stock 2025-11-24 4 S false 1630.00 478.1359 D 10022.00 D Common Stock 2025-11-24 4 S false 315.00 478.731 D 9707.00 D Common Stock 2025-11-24 4 S false 640.00 480.7103 D 9067.00 D Common Stock 2025-11-24 4 S false 794.00 481.5541 D 8273.00 D Common Stock 2025-11-24 4 S false 131.00 482.2947 D 8142.00 D Stock Option 146.03 2025-11-24 4 M false 21000.00 0.00 D 2020-03-15 2027-03-15 Common Stock 21000.00 517.00 D This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on August 5, 2025. This transaction was executed in multiple trades at prices ranging from $475.60 to $476.56. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $476.63 to $477.55. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $477.63 to $478.58. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $478.63 to $478.86. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $480.10 to $481.08. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $481.18 to $482.12. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $482.21 to $482.42. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $466.72 to $467.60. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $467.72 to $468.71. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $468.76 to $469.75. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $469.77 to $470.73. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $471.33 to $472.31. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $472.34 to $473.22. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $473.40 to $474.04. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $474.55 to $475.49. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. /s/ John S. Hess, Jr. under Power of Attorney 2025-11-26