X0609 4 2026-09-30 false 0001082554 UNITED THERAPEUTICS Corp UTHR 0001106578 ROTHBLATT MARTINE A false C/O UNITED THERAPEUTICS CORPORATION 1000 SPRING STREET SILVER SPRING MD 20910 true true false false Chairperson & CEO true Common Stock 2026-09-30 4 S false 400.00 547.294 D 325963.00 I by Trust Common Stock 2026-09-30 4 S false 280.00 548.2529 D 325683.00 I by Trust Common Stock 2026-09-30 4 S false 240.00 549.3977 D 325443.00 I by Trust Common Stock 2026-09-30 4 S false 400.00 550.4675 D 325043.00 I by Trust Common Stock 2026-09-30 4 S false 160.00 551.495 D 324883.00 I by Trust Common Stock 2026-09-30 4 S false 120.00 552.6267 D 324763.00 I by Trust Common Stock 2026-09-30 4 S false 113.00 553.7787 D 324650.00 I by Trust Common Stock 2026-09-30 4 S false 207.00 554.6997 D 324443.00 I by Trust Common Stock 40513.00 D Common Stock 166.00 I by Spouse Common Stock 249108.00 I by Trust Common Stock 45596.00 I by Trust Common Stock 8902.00 I by Trust This exercise of stock options and sale of the resulting shares of common stock was pursuant to a pre-arranged 10b5-1 trading plan adopted by the reporting person on November 7, 2025. This plan will continue until the earlier of: (a) the exercise of 1,734,410 stock options, all of which expire on March 15, 2027; or (b) December 31, 2026. This transaction was executed in multiple trades at prices ranging from $554.21 to $555.20. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. Shares held in family trusts as to which the Reporting Person's spouse is sole trustee and sole beneficiary or co-trustee and settlor with power to revoke. Shares held in family trusts as to which the Reporting Person's spouse shares investment power and the Reporting Person and/or immediate family members are beneficiaries. Shares held in family trusts as to which the Reporting Person is sole trustee and sole beneficiary or co-trustee and settlor with power to revoke. This transaction was executed in multiple trades at prices ranging from $546.91 to $547.73. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. Shares held in family trusts as to which the Reporting Person shares investment power and the Reporting Person and/or immediate family members are beneficiaries. This transaction was executed in multiple trades at prices ranging from $547.94 to $548.58. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $549.01 to $549.94. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $550.04 to $551.00. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $551.17 to $551.79. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $552.21 to $553.02. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $553.21 to $554.14. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. Due to the 30 line limitation in Table I, this report is being filed across two forms. This is the second of two filings. /s/ John S. Hess, Jr. under Power of Attorney 2026-10-01