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Total number of common shares of an entity that have been sold or granted to shareholders (includes common shares that were issued, repurchased and remain in the treasury). These shares represent capital invested by the firm's shareholders and owners, and may be all or only a portion of the number of shares authorized. Shares issued include shares outstanding and shares held in the treasury.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 210

-SubTopic 10

-Section S99

-Paragraph 1

-Subparagraph (SX 210.5-02.29)

-URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682

Reference 2: http://www.xbrl.org/2003/role/presentationRef

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-Name Regulation S-X (SX)

-Number 210

-Section 02

-Paragraph 30

-Article 5

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- Definition

The amount the entity has committed to make for future royalty guarantees.

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Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 928

-SubTopic 440

-Section 50

-Paragraph 1

-URI http://asc.fasb.org/extlink&oid=6473578&loc=d3e63223-108013

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Represents the price per share the entity must pay on the repurchase of common stock issued to the counterparty of a collaborative agreement. The repurchase is at the discretion of the counterparty.

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- Definition

Represents the installment payment term under the license agreement.

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Represents the amount of milestone payment to be made upon commercial launch of product.

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Represents the notice period upon which shares may be repurchased.

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Represents the royalty as a percentage of net sales.

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Represents the remaining obligation amount of royalty payments.

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Assignment and License Agreements (Details) (USD $) In Millions, except Share data, unless otherwise specified	12 Months Ended	1 Months Ended			12 Months Ended
	Dec. 31, 1997	Jun. 30, 2006	Nov. 30, 2008	Jul. 31, 2011	Dec. 31, 2007	Dec. 31, 2014	Dec. 31, 2013
Assignment and License Agreements
Common stock issued (in shares)						65,988,561us-gaap_CommonStockSharesIssued	63,013,192us-gaap_CommonStockSharesIssued
GlaxoSmithKline PLC (Glaxo)
Assignment and License Agreements
Minimum term of royalty payment	10 years
Supernus Pharmaceuticals, Inc.
Assignment and License Agreements
Minimum term of royalty payment		12 years
Milestone payment to be made upon commercial launch of Orenitram tablet		$ 2.0
Eli Lilly and Company
Assignment and License Agreements
Royalty as a percentage of net sales			5.00%
Toray
Assignment and License Agreements
Common stock issued (in shares)					400,000
Price per share (in dollars per share)					$ 27.21
Notice period					30 days
Non-refundable payments to be made under the license				50.0
Term of installment payments under license				5 years
Royalty payments, remaining obligation						10.0