Consolidated Statements of Operations (USD $) In Thousands, except Per Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2012
Revenues:
Net product sales	$ 1,279,533	$ 1,106,944	$ 906,123
Other	8,986	10,040	9,953
Total revenues	1,288,519	1,116,984	916,076
Operating expenses:
Research and development	242,549	299,348	173,387
Selling, general and administrative	381,287	394,010	201,746
Cost of product sales	125,883	131,127	119,297
Total operating expenses	749,719	824,485	494,430
Operating income	538,800	292,499	421,646
Other (expense) income:
Interest expense	(17,592)	(18,058)	(16,639)
Other, net	3,972	4,462	35,664
Total other (expense) income, net	(13,620)	(13,596)	19,025
Income before income taxes	525,180	278,903	440,671
Income tax expense	(185,106)	(104,343)	(136,229)
Net income	$ 340,074	$ 174,560	$ 304,442
Basic
Basic (in dollars per share)	$ 7.06	$ 3.49	$ 5.84
Diluted
Diluted (in dollars per share)	$ 6.28	$ 3.28	$ 5.71
Weighted average number of common shares outstanding:
Basic (in shares)	48,176	50,076	52,093
Diluted (in shares)	54,155	53,231	53,280