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Stock-Based Compensation, Fair Value Assumptions Used (Details) - $ / shares
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Fair value assumptions used in estimating fair value of each option grant [Abstract]      
Expected stock price volatility 85.26% 84.91% 79.60%
Risk-free interest rate 2.73% 1.94% 1.85%
Expected option term 6 years 7 days 6 years 29 days 6 years 11 days
Dividend yield 0.00% 0.00% 0.00%
Options granted, weighted average grant date fair value (in dollars per share) $ 2.58 $ 2.93 $ 3.25