CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
CONSOLIDATED STATEMENTS OF OPERATIONS [Abstract]
Revenue	$ 1,547	$ 1,550	$ 1,555
Operating expense:
Royalty expense	0	884	5,265
Research and development	2,674	2,499	2,277
Selling, general and administrative expenses	16,194	26,672	23,190
Total operating expense	18,868	30,055	30,732
Loss from operations	(17,321)	(28,505)	(29,177)
Loss on change in value of derivative liability	0	0	(117)
Interest and other income, net	46	69	68
Loss before taxes	(17,275)	(28,436)	(29,226)
Income tax expense	(3)	(133)	(8)
Net loss	$ (17,278)	$ (28,569)	$ (29,234)
Basic and diluted loss per share (in dollars per share)	$ (0.30)	$ (0.51)	$ (0.56)
Weighted average shares outstanding basic and diluted (in shares)	58,354,397	55,984,825	52,384,494