X0303 4 2009-11-25 0 0001082038 DURECT CORP DRRX 0001134620 BROWN JAMES E 2 RESULTS WAY CUPERTINO CA 95014 1 1 0 0 President & CEO Common Stock 2009-11-25 4 G 0 10000 0 D 1804530 D Common Stock 560000 I by Trust Held by James and Karen Brown 1998 Trust U/A DTD 4/1/98. James E. Brown 2010-01-29