Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Revenues:
Net product sales	$ 3,518	$ 6,618
Toll manufacturing	1,023	346
Total revenues	9,847	12,256
Operating Costs and Expenses:
Cost of product sales	2,428	3,191
Cost of toll manufacturing	1,188	402
Research and development	18,502	21,968
General and administrative	6,924	8,439
Total operating costs and expenses	29,042	34,000
Loss from operations	(19,195)	(21,744)
Interest and Other Income (Expense):
Interest income	88	34
Interest expense	(1,679)	(1,696)
Loss from valuation of derivative liabilities	0	(1,549)
Other	(762)	660
Total interest and other expense, net	(2,353)	(2,551)
Net loss	$ (21,548)	$ (24,295)
Net loss per share:
Basic, in dollars per share	$ (0.09)	$ (0.10)
Diluted, in dollars per share	$ (0.09)	$ (0.10)
Shares used in calculating net loss per share:
Basic, in shares	242,876	235,703
Diluted, in shares	242,876	235,703
Comprehensive Loss:
Net loss	$ (21,548)	$ (24,295)
Foreign currency translation gain (loss)	2,591	(145)
Comprehensive loss	(18,957)	(24,440)
Eisai
Revenues:
Net product sales	2,459	4,436
Other collaborative revenue	3,226	2,136
Total revenues	5,685	6,572
Other
Revenues:
Other collaborative revenue	$ 2,080	$ 3,156