Leases - Additional Information (Detail) $ in Thousands	3 Months Ended		12 Months Ended
	Sep. 30, 2019 USD ($) ft²	Jun. 30, 2019 USD ($) ft²	Dec. 31, 2021 USD ($) Property	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)	Dec. 31, 2018	Dec. 31, 2016	Jan. 01, 2019 USD ($)
Operating Leased Assets [Line Items]
Number of properties under sale and leaseback agreements | Property			3
Percentage of annual increase in monthly lease payments			2.50%
Sale and leaseback transaction, interest expense			$ 4,100	$ 4,500	$ 4,800
Sale leaseback transactions income statement interest expense, remaining period			12,600
Sale and leaseback transaction, total financing obligation			41,211
Add amounts representing residual value			5,000
Operating lease, right-of-use asset			$ 9,100
Operating lease, right-of-use asset, statement of financial position [extensible list]			Other Assets, Noncurrent
Operating lease, right-of-use liabilities			$ 1,800
Operating lease, liability, current, statement of financial position [Extensible List]			Accounts payable and other accrued liabilities
Operating lease liabilities, non current			$ 8,300
Operating lease, liability, noncurrent, statement of financial position [Extensible List]			Other long-term liabilities
Operating lease, expense			$ 2,400	2,400	1,900
Operating lease, weighted average remaining lease term			4 years 9 months 18 days
Sublease expiration period						2027-05	2027-05
Sublease income			$ 3,000	$ 3,000	$ 3,000
Maximum
Operating Leased Assets [Line Items]
Lease term period			12 months
ASC 842
Operating Leased Assets [Line Items]
Operating lease, liability								$ 6,300
Operating lease, right-of-use asset								$ 5,900
Weighted average discount rate								7.25%
San Diego, California
Operating Leased Assets [Line Items]
Percentage of annual increase in monthly lease payments			2.50%
Operating lease agreement expiration date			2027-05
Boston, Massachusetts
Operating Leased Assets [Line Items]
Percentage of annual increase in monthly lease payments	2.00%
Operating lease, right-of-use asset	$ 5,200
Weighted average discount rate	7.25%
Operating lease inception date	Sep. 01, 2019
Area of office space | ft²	12,755
Zug, Switzerland
Operating Leased Assets [Line Items]
Operating lease agreement expiration date		2024-05
Operating lease, liability		$ 1,400
Operating lease, right-of-use asset		$ 1,500
Weighted average discount rate		7.25%
Area of office space | ft²	4,050	10,500
Additional office space, lease inception date	Jan. 01, 2020	Jun. 01, 2019