<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2010-03-22</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000946581</issuerCik>
        <issuerName>TAKE TWO INTERACTIVE SOFTWARE INC</issuerName>
        <issuerTradingSymbol>TTWO</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0000921669</rptOwnerCik>
            <rptOwnerName>ICAHN CARL C</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>767 FIFTH AVE., 47TH FLR.</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10153</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0000928464</rptOwnerCik>
            <rptOwnerName>HIGH RIVER LIMITED PARTNERSHIP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>445 HAMILTON AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 1210</rptOwnerStreet2>
            <rptOwnerCity>WHITE PLAINS</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10601</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0000860851</rptOwnerCik>
            <rptOwnerName>BARBERRY CORP.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>445 HAMILTON AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 1210</rptOwnerStreet2>
            <rptOwnerCity>WHITE PLAINS</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10601</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001322824</rptOwnerCik>
            <rptOwnerName>Hopper Investments LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>445 HAMILTON AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 1210</rptOwnerStreet2>
            <rptOwnerCity>WHITE PLAINS</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10601</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001313666</rptOwnerCik>
            <rptOwnerName>ICAHN PARTNERS LP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>767 FIFTH AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2>47TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10153</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001322827</rptOwnerCik>
            <rptOwnerName>ICAHN PARTNERS MASTER FUND LP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O WALKER HOUSE</rptOwnerStreet1>
            <rptOwnerStreet2>87 MARY STREET</rptOwnerStreet2>
            <rptOwnerCity>GEORGE TOWN, GRAND CAYMAN</rptOwnerCity>
            <rptOwnerState>E9</rptOwnerState>
            <rptOwnerZipCode>KY1-9001</rptOwnerZipCode>
            <rptOwnerStateDescription>CAYMAN ISLANDS</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001414181</rptOwnerCik>
            <rptOwnerName>ICAHN PARTNERS MASTER FUND II L.P.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O WALKER HOUSE</rptOwnerStreet1>
            <rptOwnerStreet2>87 MARY STREET</rptOwnerStreet2>
            <rptOwnerCity>GRAND CAYMAN, CAYMAN ISLANDS</rptOwnerCity>
            <rptOwnerState>E9</rptOwnerState>
            <rptOwnerZipCode>KY1-9001</rptOwnerZipCode>
            <rptOwnerStateDescription>CAYMAN ISLANDS</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001414179</rptOwnerCik>
            <rptOwnerName>ICAHN PARTNERS MASTER FUND III L.P.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O WALKER HOUSE</rptOwnerStreet1>
            <rptOwnerStreet2>87 MARY STREET</rptOwnerStreet2>
            <rptOwnerCity>GRAND CAYMAN, CAYMAN ISLANDS</rptOwnerCity>
            <rptOwnerState>E9</rptOwnerState>
            <rptOwnerZipCode>KY1-9001</rptOwnerZipCode>
            <rptOwnerStateDescription>CAYMAN ISLANDS</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001080113</rptOwnerCik>
            <rptOwnerName>BECKTON CORP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>445 HAMILTON AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 1210</rptOwnerStreet2>
            <rptOwnerCity>WHITE PLAINS</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10601</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001257324</rptOwnerCik>
            <rptOwnerName>ICAHN ENTERPRISES G.P. INC.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>445 HAMILTON AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 1210</rptOwnerStreet2>
            <rptOwnerCity>WHITE PLAINS</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10601</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock, par value $0.01 per share (&quot;Shares&quot;)</value>
            </securityTitle>
            <transactionDate>
                <value>2010-03-22</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>36653</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>9.96</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>11620526</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See FNS</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F2"/>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
                    <footnoteId id="F5"/>
                    <footnoteId id="F6"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">High River Limited Partnership (&quot;High River&quot;) directly beneficially owns 2,324,104 Shares, Icahn Partners LP (&quot;Icahn
 Partners&quot;) directly beneficially owns 3,436,075 Shares, Icahn Partners Master Fund LP (&quot;Icahn Master&quot;) directly beneficially
 owns 3,866,980 Shares, Icahn Partners Master Fund II LP (&quot;Icahn Master II&quot;) directly beneficially owns 1,446,200 Shares, and
 Icahn Partners Master Fund III LP (&quot;Icahn Master III&quot;) directly beneficially owns 547,167 Shares.</footnote>
        <footnote id="F2">Barberry Corp. (&quot;Barberry&quot;), is the sole member of Hopper Investments LLC (&quot;Hopper&quot;), which is the general partner of High
 River. Beckton Corp. (&quot;Beckton&quot;) is the sole stockholder of Icahn Enterprises G.P. Inc. (&quot;Icahn Enterprises GP&quot;), which is
 the general partner of Icahn Enterprises Holdings L.P. (&quot;Icahn Enterprises Holdings&quot;). Icahn Enterprises Holdings is the
 sole member of IPH GP LLC (&quot;IPH&quot;), which is the general partner of Icahn Capital LP (&quot;Icahn Capital&quot;). Icahn Capital is the
 general partner of each of Icahn Onshore LP (&quot;Icahn Onshore&quot;) and Icahn Offshore LP (&quot;Icahn Offshore&quot;). Icahn Onshore is the
 general partner of Icahn Partners. Icahn Offshore is the general partner of each of Icahn Master, Icahn Master II and Icahn
 Master III.</footnote>
        <footnote id="F3">Each of Barberry and Beckton is 100 percent owned by Carl C. Icahn. As such, Mr. Icahn is in a position indirectly to
 determine the investment and voting decisions made by each of High River, Icahn Partners, Icahn Master, Icahn Master II and
 Icahn Master III. Each of Hopper, Barberry and Mr. Icahn may be deemed to indirectly beneficially own (as that term is
 defined in Rule 13d-3 under the Act) the Shares which High River owns. Each of Hopper, Barberry and Mr. Icahn disclaims
 beneficial ownership of such Shares except to the extent of their pecuniary interest therein.</footnote>
        <footnote id="F4">Each of Icahn Onshore, Icahn Capital, IPH, Icahn Enterprises Holdings, Icahn Enterprises GP, Beckton and Mr. Icahn may be
 deemed to indirectly beneficially own (as that term is defined in Rule 13d-3 under the Act) the Shares which Icahn Partners
 owns. Each of Icahn Onshore, Icahn Capital, IPH, Icahn Enterprises Holdings, Icahn Enterprises GP, Beckton and Mr. Icahn
 disclaims beneficial ownership of such Shares except to the extent of their pecuniary interest therein.</footnote>
        <footnote id="F5">Each of Icahn Offshore, Icahn Capital, IPH, Icahn Enterprises Holdings, Icahn Enterprises GP, Beckton and Mr. Icahn may be
 deemed to indirectly beneficially own (as that term is defined in Rule 13d-3 under the Act) the Shares which each of Icahn
 Master, Icahn Master II and Icahn Master III owns. Each of Icahn Offshore, Icahn Capital, IPH, Icahn Enterprises Holdings,
 Icahn Enterprises GP, Beckton and Mr. Icahn disclaims beneficial ownership of such Shares except to the extent of their
 pecuniary interest therein.</footnote>
        <footnote id="F6">Please reference the Form 4 filing dated March 25, 2010, filed separately by certain other related Reporting Persons.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Carl C. Icahn</signatureName>
        <signatureDate>2010-03-25</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ High River Limited Parternship</signatureName>
        <signatureDate>2010-03-25</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Barberry Corp.</signatureName>
        <signatureDate>2010-03-25</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Hopper Investments LLC</signatureName>
        <signatureDate>2010-03-25</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Icahn Partners LP</signatureName>
        <signatureDate>2010-03-25</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Icahn Partners Master Fund LP</signatureName>
        <signatureDate>2010-03-25</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Icahn Partners Master Fund II LP</signatureName>
        <signatureDate>2010-03-25</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Icahn Partners Master Fund III LP</signatureName>
        <signatureDate>2010-03-25</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Beckton Corp.</signatureName>
        <signatureDate>2010-03-25</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Icahn Enterprises G.P. Inc</signatureName>
        <signatureDate>2010-03-25</signatureDate>
    </ownerSignature>
</ownershipDocument>
