<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2006-05-04</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0000765258</issuerCik>
        <issuerName>IMCLONE SYSTEMS INC</issuerName>
        <issuerTradingSymbol>IMCL</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0000921669</rptOwnerCik>
            <rptOwnerName>ICAHN CARL C ET AL</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O ICAHN ASSOCIATES CORP.</rptOwnerStreet1>
            <rptOwnerStreet2>767 FIFTH AVE., SUITE 4700</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10153</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001257324</rptOwnerCik>
            <rptOwnerName>AMERICAN PROPERTY INVESTORS INC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>100 SOUTH BEDFORD RD</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>MT KISCO</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10549</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001034563</rptOwnerCik>
            <rptOwnerName>AMERICAN REAL ESTATE HOLDINGS L P</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>100 SOUTH BEDFORD ROAD</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>MOUNT KISCO</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10549</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0000860851</rptOwnerCik>
            <rptOwnerName>BARBERRY CORP.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>100 SOUTH BEDFORD ROAD</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>MT KISCO</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10549</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001322824</rptOwnerCik>
            <rptOwnerName>Hopper Investments LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>100 SOUTH BEDFORD ROAD</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>MT KISCO</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10549</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0000928464</rptOwnerCik>
            <rptOwnerName>HIGH RIVER LIMITED PARTNERSHIP /NY/</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>100 S BEDFORD RD</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>MT KISCO</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10549</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001080113</rptOwnerCik>
            <rptOwnerName>BECKTON CORP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>100 S BEDFORD RD</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>MT. KISCO</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10549</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock, par value $.001 (the &quot;Shares&quot;)</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>8478452</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>PLEASE SEE FOOTNOTES</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F2"/>
                    <footnoteId id="F3"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">American Real Estate Holdings Limited Partnership (&quot;AREH&quot;) directly beneficially owns 3,175,603 Shares, Barberry Corp.
(&quot;Barberry&quot;) directly beneficially owns 900,800 Shares and High River Limited Partnership (&quot;High River&quot;) directly
beneficially owns 4,402,049 Shares.  Beckton Corp. (&quot;Beckton&quot;) is the sole shareholder of American Property Investors,
Inc. (&quot;API&quot;), which is the general partner of AREH.  Barberry is the sole member of Hopper Investments LLC (&quot;Hopper&quot;),
which is the general partner of High River.  Beckton and Barberry are 100 percent owned by Carl C. Icahn.  As such,
Mr. Icahn is in a position indirectly to determine the investment and voting decisions made by all of the foregoing entities.</footnote>
        <footnote id="F2">Each of Beckton and API by virtue of their relationship to AREH, may be deemed to indirectly beneficially own (as that
term is defined in Rule 13d-3 under the Act) the 3,175,603 Shares which AREH owns.  Each of Beckton and API
disclaim beneficial ownership of such Shares except to the extent of their pecuniary interest therein.  Each of Barberry
and Hopper by virtue of their relationship to High River, may be deemed to indirectly beneficially own (as that term is
defined in Rule 13d-3 under the Act) the 4,402,049 Shares which High River owns.  Each of Barberry and Hopper
disclaim beneficial ownership of such Shares except to the extent of their pecuniary interest therein.</footnote>
        <footnote id="F3">Mr. Icahn by virtue of his relationship to API, AREH, Barberry, Beckton, Hopper and High River, may be deemed to
indirectly beneficially own (as that term is defined in Rule 13d-3 under the Act) the 3,175,603 Shares which AREH owns,
the 900,800 Shares which Barberry owns, and the 4,402,049 Shares which High River owns.  Mr. Icahn disclaims
beneficial ownership of such Shares except to the extent of his pecuniary interest therein.  Gail Golden, the spouse of
Mr. Icahn, directly beneficially owns 15,000 Shares.  Mr. Icahn disclaims beneficial ownership of such Shares for all
purposes.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>CARL C. ICAHN</signatureName>
        <signatureDate>2006-05-09</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>AMERICAN PROPERTY INVESTORS INC.</signatureName>
        <signatureDate>2006-05-09</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>AMERICAN REAL ESTATE HOLDINGS LIMITED PARTNERSHIP</signatureName>
        <signatureDate>2006-05-09</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>BARBERRY CORP.</signatureName>
        <signatureDate>2006-05-09</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>HOPPER INVESTMENTS LLC</signatureName>
        <signatureDate>2006-05-09</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>HIGH RIVER LIMITED PARTNERSHIP</signatureName>
        <signatureDate>2006-05-09</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>BECKTON CORP.</signatureName>
        <signatureDate>2006-05-09</signatureDate>
    </ownerSignature>
</ownershipDocument>
