Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We consent to the incorporation by reference in this Registration Statement on Form S-8of our reports dated February 28, 2023, relating to the financial statements of Innoviva, Inc. and the effectiveness of Innoviva, Inc.'s internal control over financial reporting appearing in the Annual Report on Form 10-K of Innoviva, Inc. for the year ended December 31, 2022.

/s/ Deloitte & Touche LLP

San Jose, California

November 13, 2023