CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023
Cash flows from operating activities
Net income	$ 1,847	$ 36,145
Adjustments to reconcile net income to net cash provided by operating activities:
Deferred income taxes	(12,009)	533
Amortization of capitalized fees and depreciation of property and equipment	6,986	6,954
Amortization of acquired intangible assets	12,880	8,763
Inventory fair value step-up adjustment included in cost of products sold	10,306	13,750
Stock-based compensation	3,098	3,118
Amortization of debt discount and issuance costs	1,048	1,032
Changes in fair values of equity method investments, net	24,766	4,094
Changes in fair values of equity and long-term investments, net	43,891	2,247
Accrued interest income added to long-term investments	0	(1,482)
Other non-cash items	(153)	1,061
Changes in operating assets and liabilities:
Accounts receivable	(12,328)	(5,874)
Receivables from collaboration arrangement	2,423	(11,049)
Inventory	(6,233)	(4,699)
Prepaid expenses	13,146	9,024
Other assets	1,604	1,534
Accounts payable	(4,678)	1,653
Accrued personnel-related expenses and other accrued liabilities	(5,950)	(3,260)
Accrued interest payable	0	(937)
Income tax payable	(543)	99
Deferred revenue	(422)	1,160
Net cash provided by operating activities	80,765	63,866
Cash flows from investing activities
Purchases of trading securities	(43,136)	0
Purchases of equity and long-term investments	0	(35,689)
Purchases of equity investments managed by ISP Fund LP	(30,892)	(17,784)
Sales of equity investments managed by ISP Fund LP	5,976	2,482
Purchase and sales of other investments managed by ISP Fund LP, net	24,916	15,302
Purchases of property and equipment	0	(33)
Sale of property and equipment	98	0
Net cash used in investing activities	(43,038)	(35,722)
Cash flows from financing activities
Repurchase of common stock	(14,777)	(50,021)
Repurchase of shares to satisfy tax withholding	(105)	(54)
Proceeds from issuances of common stock, net	645	111
Payment for repurchase of convertible subordinated notes due 2023	0	(96,204)
Net cash used in financing activities	(14,237)	(146,168)
Net increase (decrease) in cash and cash equivalents	23,490	(118,024)
Cash and cash equivalents at beginning of period	193,513	291,049
Cash and cash equivalents at end of period	217,003	173,025
Supplemental Disclosure of Cash Flow Information:
Cash paid for interest	5,179	6,202
Supplemental Disclosure of Non-cash Investing and Financing Activities:
Accrued interest income converted to long-term investments	$ 799	$ 0