10-Q

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

FORM 10-Q

(Mark One)

☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended June 30, 2022

OR

☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from to

Commission File Number: 000-30319

INNOVIVA, INC.

(Exact Name of Registrant as Specified in its Charter)

Delaware	94-3265960
(State or Other Jurisdiction of Incorporation or Organization)	(I.R.S. Employer Identification No.)

1350 Old Bayshore Highway Suite 400

Burlingame, CA 94010

(Address of Principal Executive Offices)

(650) 238-9600

(Registrant’s Telephone Number, Including Area Code)

Securities registered pursuant to Section 12(b) of the Act:

Title of each class	Trading Symbol(s)	Name of each exchange on which registered
Common Stock, par value $0.01 per share	INVA	The NASDAQ Global Select Market

Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes ☒ No ☐

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes ☒ No ☐

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Act.

Large accelerated filer ☒	Accelerated filer ☐
Non-accelerated filer ☐	Smaller reporting company ☐
	Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Act). Yes ☐ No ☒

The number of shares of registrant’s common stock outstanding on July 15, 2022 was 69,705,967.

TABLE OF CONTENTS

PART I. FINANCIAL INFORMATION
Item 1. Financial Statements	3
Condensed Consolidated Balance Sheets as of June 30, 2022 (Unaudited) and December 31, 2021	3
Unaudited Condensed Consolidated Statements of Income for the Three and Six Months ended June 30, 2022 and 2021	4
Unaudited Condensed Consolidated Statements of Comprehensive Income for the Three and Six Months ended June 30, 2022 and 2021	5
Unaudited Condensed Consolidated Statements of Stockholders’ Equity for the Three and Six Months ended June 30, 2022 and 2021	6
Unaudited Condensed Consolidated Statements of Cash Flows for the Six Months ended June 30, 2022 and 2021	8
Notes to Unaudited Condensed Consolidated Financial Statements	9
Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations	31
Item 3. Quantitative and Qualitative Disclosures About Market Risk	38
Item 4. Controls and Procedures	38
PART II. OTHER INFORMATION
Item 1. Legal Proceedings	38
Item 1A. Risk Factors	38
Item 2. Unregistered Sales of Equity Securities and Use of Proceeds	38
Item 3. Defaults Upon Senior Securities	39
Item 4. Mine Safety Disclosure	39
Item 5. Other Information	39
Item 6. Exhibits	40
Signatures	42

2

PART I. FINANCIAL INFORMATION

Item 1. Financial Statements

INNOVIVA, INC.

CONDENSED CONSOLIDATED BALANCE SHEETS

(In thousands, except per share data)

	June 30,			December 31,
	2022			2021
	(unaudited)			*
Assets
Current assets:
Cash and cash equivalents	$	283,580		$	201,525
Related party receivables from collaborative arrangements		111,676			110,711
Prepaid expenses		3,953			1,367
Other current assets		1,119			70
Total current assets		400,328			313,673
Property and equipment, net		176			12
Equity and long-term investments		494,097			483,845
Capitalized fees paid to a related party, net		104,518			111,430
Right-of-use assets		3,545			97
Goodwill		5,544			—
Intangible assets		105,000			—
Deferred tax assets, net		23,274			17,327
Other assets		1,157			11
Total assets	$	1,137,639		$	926,395
Liabilities and Stockholders’ Equity
Current liabilities:
Accounts payable	$	4,323		$	27
Accrued personnel-related expenses		3,871			619
Accrued interest payable		4,498			4,152
Convertible subordinated notes due 2023,    net of issuance costs		96,072			—
Other accrued liabilities		17,144			1,009
Total current liabilities		125,908			5,807
Long-term debt, net of discount and issuance costs		443,178			394,653
Lease liabilities, long-term		3,091			—
Commitments and contingencies (Note 10)
Stockholders’ equity:
Preferred stock: $0.01 par value, 230 shares authorized,    no shares issued and outstanding		—			—
Common stock: $0.01 par value, 200,000 shares authorized,    69,706 and 69,566 issued and outstanding as of    June 30, 2022 and December 31, 2021 respectively		697			696
Treasury stock: at cost, 32,005 shares at June 30, 2022    and December 31, 2021, respectively		(393,829	)		(393,829	)
Additional paid-in capital		1,183,667			1,264,024
Accumulated deficit		(402,198	)		(456,148	)
Total Innoviva stockholders’ equity		388,337			414,743
Noncontrolling interest		177,125			111,192
Total stockholders’ equity		565,462			525,935
Total liabilities and stockholders’ equity	$	1,137,639		$	926,395

*Consolidated balance sheet as of December 31, 2021 has been derived from audited consolidated financial statements.

See accompanying notes to condensed consolidated financial statements.

3

INNOVIVA, INC.

CONDENSED CONSOLIDATED STATEMENTS OF INCOME

(In thousands, except per share data)

(Unaudited)

	Three Months Ended June 30,						Six Months Ended June 30,
	2022			2021			2022			2021
Royalty revenue from a related party, net of amortization    of capitalized fees paid to a related party of $3,456     in the three months ended June 30, 2022 and 2021, and    $6,912 in the six months ended June 30, 2022 and 2021	$	108,220		$	100,806		$	198,279		$	186,324
Operating expenses:
Research and development		13,884			38			19,722			87
General and administrative		11,782			4,228			18,274			10,214
Total operating expenses		25,666			4,266			37,996			10,301
Income from operations		82,554			96,540			160,283			176,023
Interest and dividend income		724			20			1,046			50
Other expense, net		(528	)		(951	)		(778	)		(1,384	)
Interest expense		(3,655	)		(4,745	)		(6,665	)		(9,439	)
Loss on debt extinguishment		—			—			(20,662	)		—
Changes in fair values of equity and    long-term investments, net		(58,600	)		45,315			(68,011	)		100,360
Income before income taxes		20,495			136,179			65,213			265,610
Income tax expense (benefit), net		(876	)		25,333			5,984			45,069
Net income		21,371			110,846			59,229			220,541
Net income attributable to    noncontrolling interest		20,432			21,898			42,517			37,470
Net income attributable to    Innoviva stockholders	$	939		$	88,948		$	16,712		$	183,071
Basic net income per share attributable to    Innoviva stockholders	$	0.01		$	1.01		$	0.24		$	1.93
Diluted net income per share attributable    to Innoviva stockholders	$	0.05		$	0.90		$	0.24		$	1.73
Shares used to compute Innoviva basic and diluted    net income per share:
Shares used to compute basic net income per share		69,643			88,423			69,594			94,858
Shares used to compute diluted net income per share		95,653			100,639			94,692			107,096

See accompanying notes to condensed consolidated financial statements.

4

INNOVIVA, INC.

CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME

(In thousands)

(Unaudited)

	Three Months Ended June 30,				Six Months Ended June 30,
	2022		2021		2022		2021
Net income	$	21,371	$	110,846	$	59,229	$	220,541
Comprehensive income		21,371		110,846		59,229		220,541
Comprehensive income attributable to noncontrolling interest		20,432		21,898		42,517		37,470
Comprehensive income attributable to Innoviva stockholders	$	939	$	88,948	$	16,712	$	183,071

See accompanying notes to condensed consolidated financial statements.

5

INNOVIVA, INC.

CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY

(In thousands)

(Unaudited)

	Six Months Ended June 30, 2022
					Additional			Accumulated Other													Total
	Common Stock				Paid-In			Comprehensive		Accumulated			Treasury Stock					Noncontrolling			Stockholders’
	Shares		Amount		Capital			Income (Loss)		Deficit			Shares		Amount			Interest			Equity
Balance as of    December 31, 2021		69,566	$	696	$	1,264,024		$	—	$	(456,148	)		32,005	$	(393,829	)	$	111,192		$	525,935
Cumulative adjustment due to adoption of ASU 2020-06		—		—		(65,361	)		—		37,238			—		—			—			(28,123	)
Distributions to    noncontrolling interest		—		—		—			—		—			—		—			(6,507	)		(6,507	)
Fair value of noncontrolling    interest in a consolidated    variable interest entity		—		—		—			—		—			—		—			38,471			38,471
Exercise of stock options,    and issuance of common    stock units and stock    awards, net of repurchase    of shares to satisfy tax    withholding		28		—		214			—		—			—		—			—			214
Stock-based compensation		—		—		620			—		—			—		—			334			954
Capped call options    associated with    convertible senior    notes due 2028		—		—		(16,585	)		—		—			—		—			—			(16,585	)
Net income		—		—		—			—		15,773			—		—			22,085			37,858
Balance as of    March 31, 2022		69,594	$	696	$	1,182,912		$	—	$	(403,137	)		32,005	$	(393,829	)	$	165,575		$	552,217
Distributions to    noncontrolling interest				—		—			—		—			—		—			(9,545	)		(9,545	)
Equity activity of    noncontrolling interest    in a consolidated    variable interest entity		—		—		—			—		—			—		—			(2	)		(2	)
Exercise of stock options,    and issuance of common    stock units and stock    awards, net of repurchase    of shares to satisfy tax    withholding		112		1		67			—		—			—		—			—			68
Conversion of convertible    subordinated notes due    2023		—		—		3			—		—			—		—			—			3
Stock-based compensation		—		—		685			—		—			—		—			665			1,350
Net income		—		—		—			—		939			—		—			20,432			21,371
Balance as of    June 30, 2022		69,706	$	697	$	1,183,667		$	—	$	(402,198	)		32,005	$	(393,829	)	$	177,125		$	565,462

6

	Six Months Ended June 30, 2021
							Additional			Accumulated Other													Total
	Common Stock						Paid-In			Comprehensive		Accumulated			Treasury Stock					Noncontrolling			Stockholders’
	Shares			Amount			Capital			Income (Loss)		Deficit			Shares		Amount			Interest			Equity
Balance as of December 31, 2020		101,392		$	1,014		$	1,260,900		$	—	$	(722,002	)		—	$	—		$	67,925		$	607,837
Distributions to noncontrolling    interest		—			—			—			—		—			—		—			(21,285	)		(21,285	)
Equity activity of noncontrolling    interest from a consolidated    variable interest entity		—			—			—			—		—			—		—			8			8
Exercise of stock options, and    issuance of common stock    units and stock awards, net    of repurchase of shares to    satisfy tax withholding		16			—			(25	)		—		—			—		—			—			(25	)
Stock-based compensation		—			—			451			—		—			—		—			—			451
Net income		—			—			—			—		94,123			—		—			15,572			109,695
Balance as of March 31, 2021		101,408		$	1,014		$	1,261,326		$	—	$	(627,879	)		—	$	—		$	62,220		$	696,681
Distributions to noncontrolling    interest					—			—			—		—			—		—			(20,161	)		(20,161	)
Equity activity of noncontrolling    interest from a consolidated    variable interest entity		—			—			—			—		—			—		—			8			8
Exercise of stock options, and    issuance of common stock    units and stock awards, net    of repurchase of shares to    satisfy tax withholding		92			1			49			—		—			—		—			—			50
Repurchase of common stock		(32,005	)		(320	)		—			—		—			32,005		(393,829	)		—			(394,149	)
Stock-based compensation		—			—			470			—		—			—		—			—			470
Net income		—			—			—			—		88,948			—		—			21,898			110,846
Balance as of June 30, 2021		69,495		$	695		$	1,261,845		$	—	$	(538,931	)	$	32,005	$	(393,829	)	$	63,965		$	393,745

See accompanying notes to condensed consolidated financial statements.

7

INNOVIVA, INC.

CONDENSED CONSOLIDATED STATEMENT OF CASH FLOWS

(In thousands)

(Unaudited)

	Six Months Ended June 30,
	2022			2021
Cash flows from operating activities
Net income	$	59,229		$	220,541
Adjustments to reconcile net income to net cash provided by operating activities:
Deferred income tax		5,984			45,069
Depreciation and amortization		7,092			6,918
Stock-based compensation		2,304			921
Amortization of debt discount and issuance costs		931			4,472
Changes in fair values of equity and long-term investments, net		68,011			(99,046	)
Loss on extinguishment of debt		20,662			—
Other		857			16
Changes in operating assets and liabilities:
Receivables from collaborative arrangements		(965	)		(10,331	)
Prepaid expenses		2,968			578
Other assets, current		910			328
Other assets, non-current		(844	)		—
Accounts payable		2,713			(36	)
Accrued personnel-related expenses and other accrued liabilities		6,939			(709	)
Accrued interest payable		346			—
Net cash provided by operating activities		177,137			168,721
Cash flows from investing activities
Purchases of equity and long-term investments		(58,726	)		(46,373	)
Purchases of equity investments managed by ISP Fund LP		(38,026	)		(142,636	)
Sales of equity investments managed by ISP Fund LP		24,281			18,545
Purchase and sales of other investments managed by ISP Fund LP, net		(96,255	)		234,091
Purchases of property and equipment		(22	)		—
Cash acquired through the consolidation of Entasis Therapeutics Holdings, Inc.		23,070			—
Net cash provided by (used in) investing activities		(145,678	)		63,627
Cash flows from financing activities
Distributions to noncontrolling interest		(16,054	)		(41,446	)
Repurchase of common stock		—			(394,149	)
Repurchase of shares to satisfy tax withholding		(59	)		(35	)
Proceeds from issuances of common stock, net		341			60
Payment for repurchase of convertible subordinated notes due 2023		(165,131	)		—
Purchases of capped call options associated with convertible senior notes due 2028		(21,037	)		—
Proceeds from issuance of convertible senior notes due 2028, net of issuance costs		252,536			—
Net cash provided by (used in) financing activities		50,596			(435,570	)
Net increase (decrease) in cash and cash equivalents		82,055			(203,222	)
Cash and cash equivalents at beginning of period		201,525			246,487
Cash and cash equivalents at end of period	$	283,580		$	43,265
Supplemental disclosure of cash flow information:
Cash paid for interest	$	5,411		$	4,967
Supplemental disclosure of non-cash investing and financing activities
Adoption of ASU 2020-06	$	28,123		$	—
Right-of-use asset obtained through the consolidation of    Entasis Therapeutics Holdings, Inc.	$	3,289		$	—

See accompanying notes to condensed consolidated financial statements.

8

INNOVIVA, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

(Unaudited)

1. Description of Operations and Summary of Significant Accounting Policies

Description of Operations

Innoviva Inc. (referred to as “Innoviva”, the “Company”, or “we” and other similar pronouns) is a company with a portfolio of royalties and other healthcare assets. Our royalty portfolio contains respiratory assets partnered with Glaxo Group Limited (“GSK”), including RELVAR®/BREO® ELLIPTA® (fluticasone furoate/ vilanterol, “FF/VI”), ANORO® ELLIPTA® (umeclidinium bromide/ vilanterol, “UMEC/VI”) and TRELEGY® ELLIPTA® (the combination FF/UMEC/VI). Under the Long-Acting Beta2 Agonist (“LABA”) Collaboration Agreement, Innoviva is entitled to receive royalties from GSK on sales of RELVAR®/BREO® ELLIPTA® as follows: 15% on the first $3.0 billion of annual global net sales and 5% for all annual global net sales above $3.0 billion; and royalties from the sales of ANORO® ELLIPTA®, which tier upward at a range from 6.5% to 10%. Innoviva is also entitled to 15% of royalty payments made by GSK under its agreements originally entered into with us, and since assigned to Theravance Respiratory Company, LLC (“TRC”), including TRELEGY® ELLIPTA® and any other product or combination of products that may be discovered or developed in the future under the LABA Collaboration Agreement and the Strategic Alliance Agreement with GSK (referred to herein as the “GSK Agreements”), which have been assigned to TRC other than RELVAR®/BREO® ELLIPTA® and ANORO® ELLIPTA®.

Basis of Presentation

The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America (“US GAAP”) for interim financial information. Accordingly, they do not include all of the information and notes required by US GAAP for complete financial statements. In our opinion, the unaudited condensed consolidated financial statements have been prepared on the same basis as audited consolidated financial statements and include all adjustments, consisting of only normal recurring adjustments, necessary for the fair presentation of our financial position, results of operations, comprehensive income and cash flows. The interim results are not necessarily indicative of the results of operations to be expected for the year ending December 31, 2022 or any other period.

The accompanying unaudited condensed consolidated financial statements include the accounts of Innoviva, our wholly-owned subsidiaries and certain variable interest entities for which we are the primary beneficiary. All intercompany balances and transactions have been eliminated in consolidation. For consolidated entities where we own or are exposed to less than 100% of the economics, we record net income attributable to noncontrolling interest in our unaudited condensed consolidated statements of income equal to the percentage of the economic or ownership interest retained in such entities by the respective noncontrolling parties. The accompanying unaudited condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and notes thereto included in our Annual Report on Form 10-K for the year ended December 31, 2021 filed with the Securities and Exchange Commission (“SEC”) on February 28, 2022, and as amended on March 17, 2022 (“2021 Form 10-K”).

Prior Period Immaterial Correction

Subsequent to the issuance of the unaudited condensed consolidated financial statements for the three and six months ended June 30, 2021, the Company identified that (i) purchases of equity investments managed by ISP Fund LP for $142.6 million, (ii) sales of equity investments managed by ISP Fund LP for $18.5 million, and (iii) purchase and sales of other investments managed by ISP Fund LP, net for $234.1 million were incorrectly netted in the unaudited condensed consolidated statement of cash flows within the distribution of equity and long-term investments line item. The Company has corrected the presentation in the accompanying unaudited condensed consolidated statement of cash flows for the six months ended June 30, 2021 from amounts previously reported to present such line items separately. The correction did not impact total cash flows from investing activities or the unaudited condensed consolidated balance sheet, statement of income, or statement of comprehensive income. Management assessed the correction on a quantitative and qualitative basis and determined that it is immaterial to the prior period unaudited condensed consolidated financial statements.

9

Use of Management’s Estimates

The preparation of unaudited condensed consolidated financial statements in conformity with US GAAP requires management to make estimates and assumptions that affect the amounts reported in the unaudited condensed consolidated financial statements and accompanying notes. Actual results could differ materially from those estimates. Management evaluates its significant accounting policies and estimates on an ongoing basis. We base our estimates on historical experience and other relevant assumptions that we believe to be reasonable under the circumstances. These estimates also form the basis for making judgments about the carrying values of assets and liabilities when these values are not readily apparent from other sources.

Certain Risks and Concentrations

Our financial instruments that are exposed to concentrations of credit risk consist primarily of cash and cash equivalents, marketable securities, equity and long-term investments. Although we deposit our cash with multiple financial institutions, our deposits, at times, may exceed federally insured limits.

Segment Reporting

We operate in a single segment, which is to provide capital return to stockholders by maximizing the potential value of our respiratory assets partnered with GSK. Revenues are generated from our collaborative arrangements and royalty payments from GSK, located in Great Britain. Our facilities are located within the United States.

Variable Interest Entities

We evaluate our ownership, contractual and other interest in entities to determine if they are a variable interest entity (“VIE”). We evaluate whether we have a variable interest in those entities and the nature and extent of those interests. Based on our evaluation, if we determine we are the primary beneficiary of a VIE, we consolidate the entity in our financial statements.

Equity and Long-Term Investments

We invest from time to time in equity and debt securities of private or public companies. If we determine that we have control over these companies under either voting or VIE models, we include them in our unaudited condensed consolidated financial statements. If we determine that we do not have control over these companies under either voting or VIE models, we then determine if we have an ability to exercise significant influence via voting interests, board representation or other business relationships.

We may account for the investments where we exercise significant influence using either an equity method of accounting or at fair value by electing the fair value option under Accounting Standards Codification (“ASC”) Topic 825, Financial Instruments. If the fair value option is applied to an investment that would otherwise be accounted for under the equity method, we apply it to all our financial interests in the same entity (equity and debt, including guarantees) that are eligible items. All gains and losses from fair value changes, unrealized and realized, are presented as changes in fair values of equity and long-term investments, net on the unaudited condensed consolidated statements of income.

If we conclude that we do not have an ability to exercise significant influence over an investee, we may elect to account for the security without a readily determinable fair value using the measurement alternative under ASC Topic 321, Investments - Equity Securities. This measurement alternative allows us to measure the equity investment at its cost minus impairment, if any, plus or minus changes resulting from observable price changes in orderly transactions for the identical or a similar investment of the same issuer.

We also invest in ISP Fund LP, which investments consist of money market funds and equity securities in the healthcare, pharmaceutical and biotechnology industries. Pursuant to the Partnership Agreement entered in December 2020, we became a limited partner of this partnership, and our contributions are subject to a 36-month lock-up period which restriction prevents us from having control and access to the contributions and related investments. These investments are classified as long-term investments on the unaudited condensed consolidated balance sheets.

10

Revenue Recognition

Revenue is recognized when our customer obtains control of promised goods or services, in an amount that reflects the consideration which we expect to receive in exchange for those goods or services. Revenue is recognized through a five-step process: (i) identify the contract with the customer; (ii) identify the performance obligations in the contract; (iii) determine the transaction price for the contract; (iv) allocate the transaction price to the performance obligations in the contract; and (v) recognize revenue as a performance obligation is satisfied.

We recognize the royalty revenue on net sales of products with respect to which we have contractual royalty rights in the period in which the royalties are earned. The net sales reports provided by our partner are based on its methodology and assumptions to estimate rebates and returns, which it monitors and adjusts regularly in light of contractual and legal obligations, historical trends, past experience and projected market conditions. Our partner may make significant adjustments to its sales based on actual results recorded, which could cause our royalty revenue to fluctuate. We have the ability to conduct periodic royalty audits to evaluate the information provided by our partner. Royalties are recognized net of amortization of capitalized fees associated with any approval and launch milestone payments made to GSK.

Research and Development Costs

Research and development costs are expensed in the period that services are rendered or goods are received. Research and development costs consist of salaries and benefits, laboratory supplies and facility costs, as well as fees paid to third parties that conduct certain research and development activities on behalf of the Company’s consolidated variable interest entity, net of certain external research and development costs reimbursed under the collaboration arrangements of the Company’s consolidated variable interest entity. Non-refundable pre-payments for goods or services that will be used or rendered for future research and development activities are deferred. The Company’s consolidated variable interest entity also utilizes significant judgment and estimates to record accruals for estimated ongoing research costs based on the progress of the studies.

Goodwill and Intangible Assets

Goodwill is recognized as the excess of the purchase price of an acquired entity over the fair value of amount assigned to assets acquired and liabilities assumed in a business combination. Goodwill and intangible assets with indefinite lives is subject to impairment testing at least annually and will be tested for impairment between annual tests if a triggering event occurs, such as changes due to circumstances that would indicate an impairment of the carrying value. Significant judgments are involved in determining if an indicator of impairment has occurred. Intangible assets with definite lives are amortized on a straight-line basis over the remaining useful life of the intangible asset.

Operating Leases

We account for our leases in accordance with Financial Accounting Standards Board (“FASB”) Accounting Standards Codification (“ASC”) 842, “Leases” (“ASC 842”). Right-of-use assets represent our right to use an underlying asset over the lease term and include any lease payments made prior to the lease commencement date and are reduced by lease incentives. Lease liabilities represent the present value of the total lease payments over the lease term, calculated using an estimated incremental borrowing rate. Lease expense is recognized on a straight-line basis over the expected lease term.

Accounting Pronouncement Adopted by the Company

In August 2020, the FASB issued ASU 2020-06, Debt-Debt with Conversion and Other Options (Subtopic 470-20) and Derivatives and Hedging-Contracts in Entity’s Own Equity (Subtopic 815-40): Accounting for Convertible Instruments and Contracts in an Entity’s Own Equity, which is intended to simplify the accounting for convertible instruments by removing certain separation models in Subtopic 470-20 for convertible instruments. Consequently, a convertible debt instrument will be accounted for as a single liability measured at its amortized cost, as long as no other features require bifurcation and recognition as derivatives. The new standard also requires the if-converted method to be used to calculate diluted earnings per share (“EPS”) for convertible instruments.

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Effective January 1, 2022, we adopted the new standard using the modified retrospective approach and assessed the effect of this adoption on the accounting for our outstanding convertible notes. The effect of the adoption on our 2025 Notes (as defined below) resulted in a decrease to the opening balance of accumulated deficit of $37.2 million, a reduction to additional paid-in capital of $65.4 million, an increase to the balance of the notes by an aggregate amount of $35.6 million, and an increase to deferred tax assets of $7.4 million. The dilutive EPS of our 2025 Notes will be computed under the if-converted method going forward. There was no financial impact from the implementation of the standard for our 2023 Notes (as defined below). Refer to Note 8, “Debt” for more information.

2. Net Income Per Share

Basic net income per share attributable to Innoviva stockholders is computed by dividing net income attributable to Innoviva stockholders by the weighted-average number of shares of common stock outstanding. Diluted net income per share attributable to Innoviva stockholders is computed by dividing net income attributable to Innoviva stockholders by the weighted-average number of shares of common stock and dilutive potential common stock equivalents then outstanding. Dilutive potential common stock equivalents include the assumed exercise, vesting and issuance of employee stock awards using the treasury stock method, as well as common stock issuable upon assumed conversion of our convertible subordinated notes due 2023 (the “2023 Notes”), our convertible senior notes due 2025 (the “2025 Notes”) and our convertible senior notes due 2028 (the “2028 Notes”) using the if-converted method.

Our convertible senior notes due 2025 (the “2025 Notes”) are convertible, based on the applicable conversion rate, into cash, shares of our common stock or a combination thereof, at our election. Our current intent is to settle the principal amount of the 2025 Notes in cash upon conversion. The impact of the assumed conversion premium to diluted net income per share was historically computed using the treasury stock method. As the average market price per share of our common stock as reported on The Nasdaq Global Select Market was lower than the initial conversion price of $17.26 per share, there was no dilutive effect of the assumed conversion premium for the three and six months ended June 30, 2021. The dilutive EPS of the notes was approximately $0.01 and $0.03 per share, respectively, using the if-converted method for the three and six months ended June 30, 2022 as a result of the adoption of ASU 2020-06.

The following table shows the computation of basic and diluted net income per share for the three and six months ended June 30, 2022 and 2021:

	Three Months Ended June 30,				Six Months Ended June 30,
(In thousands except per share data)	2022		2021		2022		2021
Numerator:
Net income attributable to Innoviva stockholders, basic	$	939	$	88,948	$	16,712	$	183,071
Add: interest expense on 2023 Notes		570		1,163		1,591		2,367
Add: interest expense on 2025 Notes		1,375		—		2,539		—
Add: interest expense on 2028 Notes		1,709		—		2,093		—
Net income attributable to Innoviva stockholders, diluted	$	4,593	$	90,111	$	22,935	$	185,438
Denominator:
Weighted-average shares used to compute basic net income    per share attributable to Innoviva stockholders		69,643		88,423		69,594		94,858
Dilutive effect of 2023 Notes		4,866		12,189		7,511		12,189
Dilutive effect of 2025 Notes		11,150		—		11,150		—
Dilutive effect of 2028 Notes		9,955		—		6,360		—
Dilutive effect of options and awards granted under equity    incentive plan and employee stock purchase plan		39		27		77		49
Weighted-average shares used to compute diluted net income    per share attributable to Innoviva stockholders		95,653		100,639		94,692		107,096
Net income per share attributable to Innoviva stockholders
Basic	$	0.01	$	1.01	$	0.24	$	1.93
Diluted	$	0.05	$	0.90	$	0.24	$	1.73

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Anti-Dilutive Securities

The following common stock equivalents were not included in the computation of diluted net income per share because their effect was anti-dilutive for the periods presented:

	Three Months Ended June 30,				Six Months Ended June 30,
(In thousands)	2022		2021		2022		2021
Outstanding options and awards granted under equity incentive    plan and employee stock purchase plan		642		1,093		514		1,126

3. Revenue Recognition and Collaborative Arrangements

We recognize royalty revenue on net sales of products with respect to which we have contractual royalty rights in the period in which the royalties are earned. Royalties, which may include adjustments of estimates of net sales in prior periods, are recognized net of amortization of capitalized fees associated with any approval and launch milestone payments made to GSK.

Net Revenue from Collaborative Arrangements

Net revenue recognized under our GSK Agreements was as follows:

	Three Months Ended June 30,						Six Months Ended June 30,
(In thousands)	2022			2021			2022			2021
Royalties from a related party    - RELVAR/BREO	$	59,326		$	65,916		$	115,090		$	122,306
Royalties from a related party    - ANORO		9,630			11,960			18,072			22,460
Royalties from a related party    - TRELEGY		42,720			26,386			72,029			48,470
Total royalties from a related party		111,676			104,262			205,191			193,236
Less: amortization of capitalized fees    paid to a related party		(3,456	)		(3,456	)		(6,912	)		(6,912	)
Royalty revenue from GSK	$	108,220		$	100,806		$	198,279		$	186,324

4. Consolidated Entities

We consolidate the financial results of Theravance Respiratory Company, LLC (“TRC”) and Entasis Therapeutics Holdings, Inc. (“Entasis”), which we have determined to be VIEs. As we have the power to direct the economically significant activities of these entities and the obligation to absorb losses of, or the right to receive benefits from them, we are the primary beneficiary of the entities. We also consolidate the financial results of ISP Fund LP (the “Partnership”), which is our partnership with Sarissa Capital Management LP (“Sarissa Capital”), as we have determined that the Partnership is a VIE and we are its primary beneficiary.

Theravance Respiratory Company, LLC

We held 15% of the economic interest of TRC as of June 30, 2022 and December 31, 2021. The primary source of revenue for TRC is the royalties generated from the net sales of TRELEGY® ELLIPTA® by GSK. As of June 30, 2022, TRC held equity and long-term investments in InCarda Therapeutics, Inc. (“InCarda”), ImaginAb, Inc. (“ImaginAb”), Gate Neurosciences, Inc. (“Gate”) and Nanolive SA (“Nanolive”). Refer to Note 5, “Financial Instruments and Fair Value Measurements,” for more information.

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The summarized financial information for TRC is presented as follows:

Balance sheets

	June 30,		December 31,
(In thousands)	2022		2021
Assets
Cash and cash equivalents	$	89,806	$	50,713
Receivables from collaborative arrangements		42,720		42,492
Prepaid expenses and other current assets		85		71
Equity and long-term investments		42,536		37,695
Total assets	$	175,147	$	130,971
Liabilities and LLC Members’ Equity
Current liabilities	$	493	$	252
LLC members’ equity		174,654		130,719
Total liabilities and LLC members’ equity	$	175,147	$	130,971

Income statements

	Three Months Ended June 30,						Six Months Ended June 30,
(In thousands)	2022			2021			2022			2021
Royalty revenue from a related party	$	42,720		$	26,386		$	72,029		$	48,470
Operating expenses		139			336			337			3,617
Income from operations		42,581			26,050			71,692			44,853
Other income, net		10			—			10			—
Income tax expense, net		—			—			1			—
Changes in fair values of equity and long-term    investments		(9,313	)		(254	)		(8,884	)		(737	)
Net income	$	33,278		$	25,796		$	62,819		$	44,116

Entasis Therapeutics Holdings, Inc.

We started investing in Entasis in 2020 as part of our capital allocation strategy of deploying cash generated from royalty income and investing in different life sciences companies. Entasis is a clinical-stage biotechnology company focused on the discovery and development of novel antibacterial products. During the second quarter of 2020, we purchased 14,000,000 shares of common stock as well as warrants to purchase 14,000,000 additional shares of common stock of Entasis for approximately $35.0 million in cash. During the third quarter of 2020, we purchased 4,672,897 shares of Entasis common stock as well as warrants to purchase 4,672,897 additional shares of its common stock for approximately $12.5 million in cash. Effective in June 2020, after certain conditions were met with respect to the sales of Entasis equity shares, Innoviva has a right to designate two members to Entasis’ board. During the second quarter of 2021, Innoviva’s wholly owned subsidiary, Innoviva Strategic Opportunities, LLC (“ISO”) entered into a securities purchase agreement with Entasis to acquire 10,000,000 shares of Entasis common stock and warrants to purchase 10,000,000 additional shares of Entasis common stock for approximately $20.0 million.

The fair value of Entasis’ common stock is measured based on its closing market price at each balance sheet date. The warrants have an exercise price of $2.50 per share and $2.675 per share for those warrants acquired in the second and third quarter of 2020, respectively. The warrants acquired in the second quarter of 2021 have an exercise price of $2.00 per share. All of the warrants are exercisable immediately within five years from the issuance date of the warrants and include a cashless exercise option. We use the Black-Scholes-Merton pricing model to estimate the fair value of these warrants.

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On February 17, 2022, ISO entered into a securities purchase agreement with Entasis pursuant to which ISO purchased a convertible promissory note for a total purchase price of $15.0 million. The note bears an annual interest rate of 0.59% and will mature and become payable on August 18, 2022 unless it is converted at a conversion price of $1.48 before the maturity date. The financing is expected to support Entasis’ product development and operations into August 2022. With this financing, we determined that we have both (i) the power to direct the economically significant activities of Entasis and (ii) the obligation to absorb the losses, or the right to receive the benefits, that could potentially be significant to Entasis and therefore, we are the primary beneficiary of Entasis. Accordingly, we consolidated Entasis’ financial position and results of operations effective on February 17, 2022. Our equity ownership interest remained at 59.9% as of February 17, 2022, and the fair values of our holdings of Entasis common stock and warrants were remeasured and estimated at $64.5 million and $31.4 million, respectively. The remeasurement resulted in a $7.7 million loss which was included in changes in fair values of equity and long-term investments, net on the unaudited condensed consolidated statement of income for the six months ended June 30, 2022.

The fair values assigned to assets acquired and liabilities assumed are based on management’s best estimates and assumptions as of the reporting date. The Company has completed a preliminary valuation and expects to finalize it as soon as practical, but no later than one year from the acquisition date. The purchase accounting for this transaction is not yet finalized.

The following table summarizes the preliminary allocation of the fair values assigned to the assets acquired and liabilities assumed as of the date of the consolidation:

(In thousands)	February 17, 2022
Cash and cash equivalents	$	23,070
Prepaid expenses		5,554
Other current assets		1,959
Property and equipment, net		185
Right-of-use assets		527
Goodwill		5,544
Intangible assets		105,000
Other assets		302
Total assets acquired	$	142,141
Accounts payable	$	1,583
Accrued personnel-related expenses		1,057
Other current liabilities		5,096
Total liabilities assumed	$	7,736
Total assets acquired, net	$	134,405

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Entasis’ assets can only be used to settle its obligations. The following table provides the assets and liabilities of Entasis:

(In thousands)	June 30, 2022
Assets
Current assets:
Cash and cash equivalents	$	22,408
Prepaid expenses		3,177
Other current assets		1,035
Total current assets		26,620
Property and equipment, net		171
Right-of-use assets		3,503
Goodwill		5,544
Intangible assets		105,000
Other assets		1,147
Total assets	$	141,985
Liabilities
Current liabilities:
Accounts payable	$	4,025
Accrued personnel-related expenses		3,385
Other accrued liabilities		8,195
Total current liabilities		15,605
Lease liabilities, long-term		3,091
Total liabilities	$	18,696

As a result of the consolidation, we recognized a non-controlling interest of $38.5 million as of February 17, 2022. Our unaudited condensed consolidated net income for the three and six months ended June 30, 2022 included the net loss attributable to Innoviva stockholders since the consolidation date of $11.7 million and $16.3 million, respectively, for Entasis.

The following table sets forth the pro-forma consolidated results of operations for the three and six months ended June 30, 2022 and 2021 as if the consolidation of Entasis occurred on January 1, 2021. The unaudited supplemental pro forma net income is adjusted by (i) reducing $64.7 million positive change in fair value related to the equity investments in Entasis’ common stock and warrants for the three months ended June 30, 2021, and increasing $7.8 million and reducing $53.2 million for the six months ended June 30, 2022 and 2021 respectively, and (ii) an increase for acquisition-related costs of $0.1 million for the six months ended June 30, 2022 and a corresponding decrease related to such costs for the six months ended June 30, 2021, as if the expenses were incurred in 2021 instead of 2022. The pro forma results of operations are presented for informational purposes only and are not indicative of the results of operations that would have been achieved if the consolidation had taken place on the dates noted above, or of results that may occur in the future.

	Three Months Ended June 30,					Six Months Ended June 30,
(In thousands)	2022			2021		2022		2021
Revenue	$	108,220		$	100,806	$	198,279	$	186,324
Net income	$	17,221		$	34,140	$	55,248	$	144,490
Net income attributable to Innoviva stockholders	$	(3,306	)	$	17,063	$	15,727	$	116,130

On July 11, 2022, we announced the completion of our acquisition of Entasis by purchasing the remaining portion of noncontrolling interest. Refer to Note 12, “Subsequent Events,” for more information.

ISP Fund LP

In December 2020, Innoviva Strategic Partners LLC, our wholly owned subsidiary (“Strategic Partners”), contributed $300.0 million to ISP Fund LP (the “Partnership”) for investing in “long” positions in the healthcare, pharmaceutical and biotechnology sectors and became a limited partner. The general partner of the Partnership (“General Partner”) is an affiliate of Sarissa Capital.

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The Partnership Agreement provides for Sarissa Capital to receive management fees from the Partnership, payable quarterly in advance, measured based on the Net Asset Value of Strategic Partners’ capital account in the Partnership. In addition, General Partner is entitled to an annual performance fee based on the Net Profits of the Partnership during the annual measurement period.

The Partnership Agreement includes a lock-up period of thirty-six months after which Strategic Partners is entitled to make withdrawals from the Partnership as of such lock-up expiration date and each anniversary thereafter, subject to certain limitations.

In May 2021, Strategic Partners received a distribution of $110.0 million from the Partnership to provide funding to Innoviva for a strategic repurchase of shares held by GSK. On March 30, 2022, Strategic Partners made an additional capital contribution of $110.0 million to the Partnership pursuant to the letter agreement entered into between Strategic Partners, the Partnership and Sarissa Capital Fund GP LP on May 20, 2021. The capital contribution is subject to a 36-month lock up period from the contribution date.

As of June 30, 2022, we held approximately 100% of the economic interest of the Partnership. As of June 30, 2022 and December 31, 2021, total assets of the Partnership were $306.9 million and $195.8 million, respectively, of which the majority was attributable to equity and long-term investments, and total liabilities were $6.4 million and $0.2 million, respectively. The partnership’s assets can only be used to settle its own obligations. During the three and six months ended June 30, 2022, we recorded $0.5 million and $0.7 million, respectively, of net investment-related expenses incurred by the Partnership, and $6.5 million and $4.4 million, respectively, of net negative changes in fair values of equity and long-term investments on the unaudited condensed consolidated statements of income. During the three and six months ended June 30, 2021, we recorded $0.9 million and $1.3 million, respectively, of net investment-related expenses incurred by the Partnership, and $25.2 million and $31.0 million, respectively, of net positive changes in fair values of equity and long-term investments on the unaudited condensed consolidated statements of income.

5. Financial Instruments and Fair Value Measurements

Equity Investment in Armata

During the first quarter of 2020, Innoviva acquired 8,710,800 shares of common stock as well as warrants to purchase 8,710,800 additional shares of common stock of Armata Pharmaceuticals, Inc. (“Armata”) for approximately $25.0 million in cash. Armata is a clinical stage biotechnology company focused on precisely targeted bacteriophage therapeutics for antibiotic-resistant infections.

During the first quarter of 2021, ISO entered into a securities purchase agreement with Armata to acquire 6,153,847 shares of Armata common stock and warrants to purchase 6,153,847 additional shares of Armata common stock for approximately $20.0 million. Armata also entered into a voting agreement with the Company and ISO, pursuant to which the Company and ISO agreed not to vote or take any action by written consent with respect to any common shares held by the Company and ISO that represent, in the aggregate, more than 49.5% of the total number of shares of Armata’s common stock for voting on the matters related to election or removal of Armata’s board members. The voting agreement will expire the earlier of the second anniversary of the agreement effective date and approval by the FDA of any of Armata’s product candidates for marketing and commercial distribution. During the fourth quarter of 2021, ISO also purchased an additional 1,212,122 shares of Armata common stock for approximately $4.0 million.

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On February 9, 2022, ISO entered into a securities purchase agreement with Armata to acquire 9,000,000 shares of Armata common stock and warrants to purchase 4,500,000 additional shares of common stock with an exercise price of $5.00 per share for $45.0 million. The investment closed in two tranches on February 9, 2022 and March 31, 2022. The investment is intended to aid Armata in advancing its clinical pipeline and strengthening its bacteriophage platform. On February 9, 2022, Armata also entered a second amended and restated voting agreement with the Company and ISO, pursuant to which the Company and ISO agreed not to vote or take any action by written consent with respect to any common shares held by the Company and ISO that represent, in the aggregate, more than 49.5% of the total number of shares of Armata’s common stock for voting on the matters related to election or removal of Armata’s board members or amend the bylaws of Armata to reduce the maximum number of directors or set the number of directors who may serve on the board of Armata. The voting agreement will expire the earlier of the second anniversary of the agreement effective date and approval by the FDA of any of Armata’s product candidates for marketing and commercial distribution. In addition, as of February 9, 2022, Armata entered into an amended and restated investor rights agreement with the Company and ISO, pursuant to which for as long as the Company and ISO hold at least 12.5% of the outstanding shares of Armata’s common stock on a fully-diluted, the Company and ISO shall have the right to designate two directors to Armata’s board of directors, and for so long as the Company and ISO hold at least 8%, but less than 12.5%, of the outstanding shares of Armata’s common stock on a fully-diluted basis, the Company and ISO shall have the right to designate one director to Armata’s board of directors, subject to certain conditions and qualifications set forth in the amended and restated investor rights agreement. As of June 30, 2022, three of the eight members of Armata’s board of directors are also members of the board of directors of Innoviva. As of June 30, 2022 and December 31, 2021, we owned approximately 69.4% and 59.3%, respectively, of Armata’s common stock.

The investments in Armata provide Innoviva and ISO the ability to have significant influence, but not control over Armata’s operations. Armata’s business and affairs are managed under the direction of its board of directors, which Innoviva and ISO do not control. Based on our evaluation, we determined that Armata is a VIE, but Innoviva and ISO are not the primary beneficiary of the VIE. We continue to elect the fair value option to account for both Armata’s common stock and warrants. The fair value of Armata’s common stock is measured based on its closing market price. The warrants purchased in 2020, 2021 and 2022 have an exercise price of $2.87, $3.25 and $5.00 per share, respectively. All warrants are exercisable immediately within five years from the issuance date of the warrants and include a cashless exercise option. We use the Black-Scholes-Merton pricing model to estimate the fair value of these warrants with the following input assumptions: Armata’s closing market price on the valuation date, the risk-free interest rate computed based on the U.S. Treasury yield, the remaining contractual term as the expected term, and the expected stock price volatility calculated based on the historical volatility of the common stock of Armata and its peer companies.

As of June 30, 2022, the fair values of our holdings of Armata common stock and warrants were estimated at $97.6 million and $47.1 million, respectively. As of December 31, 2021, the fair values of our holdings of Armata common stock and warrants were estimated at $88.1 million and $58.6 million, respectively. The total fair value of both financial instruments in the amount of $144.7 million and $146.7 million was recorded as equity and long-term investments on the unaudited condensed consolidated balance sheets as of June 30, 2022 and December 31, 2021, respectively. During the three and six months ended June 30, 2022, we recorded $42.8 million and $47.0 million unrealized loss, respectively, as changes in fair values of equity and long-term investments, net on the unaudited condensed consolidated statements of income. During the three and six months ended June 30, 2021, we recorded $24.3 million unrealized loss and $36.9 million unrealized gains, respectively, as changes in fair values of equity and long-term investments, net on the unaudited condensed consolidated statements of income.

The summarized financial information, including the portion we do not own, is presented for Armata on a one quarter lag regardless of the date of our investments as follows:

Income Statement Information

	Three Months Ended March 31,						Six Months Ended March 31,
(In thousands)	2022			2021			2022			2021
Revenue	$	1,236		$	1,066		$	2,225		$	1,570
Loss from operations	$	(8,775	)	$	(5,435	)	$	(14,823	)	$	(11,888	)
Net loss	$	(8,774	)	$	(5,495	)	$	(14,821	)	$	(12,119	)

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Equity Investment in InCarda

During the third quarter of 2020, TRC purchased 20,469,432 shares of Series C preferred stock and a warrant to purchase 5,117,358 additional shares of Series C preferred stock of InCarda Therapeutics, Inc. (“InCarda”) (the “InCarda 2020 Warrant”) for $15.8 million, which includes $0.8 million of transaction costs. InCarda is a privately held biopharmaceutical company focused on developing inhaled therapies for cardiovascular diseases. The investment is intended to fund the ongoing clinical development of InRhythmTM (flecainide for inhalation), the company’s lead program, for the treatment of a recent-onset episode of paroxysmal atrial fibrillation. TRC has the right to designate one member to InCarda’s board. As of June 30, 2022, one of InCarda’s eight board members was designated by TRC. The InCarda 2020 Warrant is exercisable immediately with an exercise price of $0.7328 per share. In September 2021, TRC and InCarda entered into an amendment to extend the expiration date of the InCarda 2020 Warrant from October 6, 2021 to March 31, 2022. On March 9, 2022, TRC and InCarda entered into an amendment to further extend the expiration date of the InCarda 2020 Warrant from March 31, 2022 to March 31, 2023. The InCarda 2020 Warrant is recorded at fair value and subject to remeasurement at each balance sheet date.

On March 9, 2022, TRC entered into a Note and Warrant Purchase Agreement (the “InCarda Agreement”) with InCarda to acquire a convertible promissory note (the “InCarda Convertible Note”) and warrants (the “InCarda 2022 Warrant”) for $0.7 million. The InCarda Convertible Note bears an annual interest rate of 6% and will convert into Series D preferred stock upon a qualified financing, non-qualified financing, or maturity conversion. A qualified financing is defined as the first issuance or series of related issuances by InCarda of its equity securities following March 9, 2022 from which InCarda receives immediately available gross proceeds of at least $10.0 million (excluding the aggregate amount of any notes converted into equity securities pursuant to the conversion of notes or any other debt securities converted into equity securities) (the “Qualified Financing Amount”). A non-qualified financing is defined as the first issuance or series of related issuances by InCarda of its equity securities following March 9, 2022 from which InCarda receives immediately available gross proceeds of less than the Qualified Financing Amount. The InCarda 2022 Warrant entitles TRC to purchase a number of shares of equity securities equal to 100% of the principal amount of the InCarda Convertible Note divided by the number of shares issued in InCarda’s next equity financing, which is defined as the earliest to occur of specific financing events, including capital raises through public offerings. The InCarda 2022 Warrant expires on March 9, 2027. The InCarda Convertible Note and InCarda 2022 Warrant are measured at fair value.

On June 15, 2022, the principal amount and the accrued interest of the InCarda Convertible Note were converted into equity securities. In addition, TRC participated in InCarda’s Series D preferred stock financing by investing $2.3 million. In connection with the new round of financing, InCarda recapitalized its equity structure resulting in TRC owning 4,093,886 shares of InCarda’s common stock, 37,350 shares of its Series A-1 preferred stock, 20,469,432 shares of its Series C preferred stock, 8,771,780 shares of its Series D-1 preferred stock, 3,369,802 shares of its Series D-2 preferred stock, a warrant to purchase 5,117,358 shares of its Series C preferred stock at $0.73 per share and a warrant to purchase 2,490,033 shares of its Series D-2 preferred stock at $0.26 per share.

As of June 30, 2022 and December 31, 2021, TRC held 8.9% and 13.0%, respectively, of InCarda equity ownership. The investment in InCarda does not provide TRC the ability to control or have significant influence over InCarda’s operations. Based on our evaluation, we determined that InCarda is a VIE, but TRC is not the primary beneficiary of the VIE. Under the measurement alternative, the equity investment is initially recorded at its allocated cost, but the carrying value may be adjusted through earnings upon an impairment or when there is an observable price change involving the same or a similar investment with the same issuer. Due to InCarda’s equity recapitalization in the second quarter of 2022, TRC reassessed the value of its investments in InCarda using the Option Pricing Model Backsolve valuation methodology. Key assumptions used in the valuation model include an expected holding period of two years, a risk free interest rate of 3.2%, a dividend yield of 0.0% and an estimated volatility of 122.0%. The estimated volatility is calculated based on the historical volatility of a selected peer group of public companies comparable to InCarda. We recognized an impairment charge of $9.0 million. There was no impairment or other change to the value of our investments in InCarda as of December 31, 2021.

As of June 30, 2022, we recorded $7.2 million in fair value of InCarda's Series C preferred stock, Series C warrants and Series D warrants (the "InCarda Preferred Stock Warrants"), and $3.2 million for InCarda's Series D-1 preferred stock, Series D-2 preferred stock, and common stock using the measurement alternative. As of December 31, 2021, we recorded $0.4 million in fair value of InCarda’s 2020 Warrants and $15.8 million for the investment in InCarda’s Series C preferred stock using the measurement alternative. During the three and six months ended June 30, 2022, we recorded $9.6 million and $9.0 million in net unrealized loss, respectively, as changes in fair values of equity and long-term investments, net on the unaudited condensed consolidated statements of income. During the three and six months ended June 30, 2021, we recorded $0.3 million and $0.7 million of unrealized loss, respectively, as changes in fair values of equity and long-term investments, net on the unaudited condensed consolidated statements of income.

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Equity Investment in ImaginAb

During the first quarter of 2021, TRC entered into a securities purchase agreement with ImaginAb, Inc. to purchase 4,051,724 shares of ImaginAb Series C preferred stock for $4.7 million. On the same day, TRC also entered into a securities purchase agreement with one of ImaginAb’s common stockholders to purchase 4,097,157 shares of ImaginAb common stock for $1.3 million. ImaginAb is a privately held biotechnology company focused on clinically managing cancer and autoimmune diseases via molecular imaging. $0.4 million was incurred for investment due diligence costs and execution and recorded as part of the equity investment on the condensed consolidated balance sheets. As of June 30, 2022, one of ImaginAb’s five board members is designated by TRC. As of June 30, 2022 and December 31, 2021, TRC held 14.4% and 14.5% of ImaginAb equity ownership, respectively.

The investment in ImaginAb does not provide TRC the ability to control or have significant influence over ImaginAb’s operations. Based on our evaluation, we determined that ImaginAb is a VIE, but TRC is not the primary beneficiary of the VIE. Because ImaginAb’s equity securities are not publicly traded and do not have a readily determinable fair value, we have accounted for our investment in ImaginAb’s Series C preferred stock and common stock using the measurement alternative. Under the measurement alternative, the equity investment is initially recorded at its allocated cost, but the carrying value may be adjusted through earnings upon an impairment or when there is an observable price change involving the same or a similar investment with the same issuer. As of June 30, 2022 and December 31, 2021, $6.4 million was recorded as equity and long-term investments on the unaudited condensed consolidated balance sheets and there was no change to the fair value of our investment.

Convertible Promissory Note in Gate Neurosciences

During the fourth quarter of 2021, TRC entered into a Convertible Promissory Note Purchase Agreement with Gate Neurosciences, Inc. (“Gate”) to acquire a convertible promissory note (the “Gate Convertible Note”) with a principal amount of $15.0 million. Gate is a privately held biopharmaceutical company focused on developing the next generation of targeted nervous system therapies, leveraging precision medicine approaches to develop breakthrough drugs for psychiatric and neurologic diseases. The investment is intended to fund its ongoing development and research. The Gate Convertible Note bears an annual interest rate of 8% and will convert into shares of common stock of Gate upon a qualified event or into shares of shadow preferred stock of Gate (“Shadow Preferred”) upon a qualified financing. A qualifying event can be a qualified initial price offering, a qualified merger, or a merger with a special-purpose acquisition company (“SPAC”).

The number of common stock shares to be issued in a qualified event shall be equal to the amount due on the conversion date divided by the lesser of a capped conversion price (the “Capped Conversion Price”) and the qualified event price (the “Qualified Event Price”). The Capped Conversion Price is calculated as $50.0 million divided by the number of shares of common stock outstanding at such time on a fully diluted basis. The Qualified Event Price is the price per share determined by the qualified event. A qualified financing is a sale or series of sales of preferred stock where (i) at least 50 percent of counterparties are not existing shareholders, (ii) net proceeds to Gate are at least $35.0 million, and (iii) the stated or implied equity valuation of Gate is at least $80.0 million. Shadow Preferred means preferred stock having identical rights, preferences and restrictions as the preferred stock that would be issued in a qualified financing.

The investment in Gate does not provide TRC the ability to control or have significant influence over Gate’s operations. Based on our evaluation, we determined that Gate is a VIE, but TRC is not the primary beneficiary of the VIE. We have accounted for the Gate Convertible Note as a trading security, measured at fair value using a Monte Carlo simulation model with the probability of certain qualified events and the assumptions of equity value of Gate, risk-free rate, expected stock price volatility of its peer companies, and the time until a financing is raised. TRC has the right to designate one board member to Gate’s board. As of June 30, 2022, TRC has designated a board member to Gate’s board, which currently consists of three directors. As of June 30, 2022 and December 31, 2021, the fair value of the Gate Convertible Note was estimated at $15.2 million and $15.1 million, respectively, and recorded as equity and long-term investments on the unaudited condensed consolidated balance sheets. We recorded $0.3 million and $0.1 million unrealized gain, respectively, as changes in fair values of equity and long-term investments, net on the unaudited condensed consolidated statement of income for the three and six months ended June 30, 2022.

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Equity Investment in Nanolive

On February 18, 2022, TRC entered into an investment and shareholders agreement with Nanolive SA (“Nanolive”) to purchase 18,750,000 shares of Nanolive Series C preferred stock for $9.8 million (equivalent to 9.0 million CHF). Nanolive SA is a Swiss privately held life sciences company focused on developing breakthrough imaging solutions that accelerate research in growth industries such as drug discovery and cell therapy. $0.7 million was incurred for investment due diligence costs and execution and recorded as part of the equity and long-term investment on the condensed consolidated balance sheets. TRC has the right to designate one member to Nanolive’s board. TRC also has the right to designate another member, who will be mutually acceptable to TRC and another majority common stockholder, to Nanolive’s board. As of June 30, 2022, no Innoviva designees are serving on Nanolive’s seven-member board. As of June 30, 2022, TRC held 16.1% of Nanolive equity ownership.

The investment in Nanolive does not provide TRC the ability to control or have significant influence over Nanolive’s operations. Based on our evaluation, we determined that Nanolive is a VIE, but TRC is not the primary beneficiary of the VIE. Because Nanolive’s equity securities are not publicly traded and do not have a readily determinable fair value, we have accounted for our investment in Nanolive’s Series C preferred stock using the measurement alternative. Under the measurement alternative, the equity investment is initially recorded at its allocated cost, but the carrying value may be adjusted through earnings upon an impairment or when there is an observable price change involving the same or a similar investment with the same issuer. As of June 30, 2022, $10.6 million was recorded as equity and long-term investments on the unaudited condensed consolidated balance sheets and there was no change to the fair value of our investment.

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Fair Value Measurements

Our equity and long-term investments are measured at fair value on a recurring basis and our debt is carried at amortized cost basis. Equity investments accounted for using the measurement alternative are valued using Level 3 inputs.

	Estimated Fair Value Measurements as of June 30, 2022 Using:
	Quoted Price in Active Markets for		Significant Other		Significant
	Identical		Observable		Unobservable
Types of Instruments	Assets		Inputs		Inputs
(In thousands)	Level 1		Level 2		Level 3		Total
Assets
Money market funds	$	156,460	$	—	$	—	$	156,460
Investments held by ISP Fund LP (1)		304,810		—		2,053		306,863
Equity investment - Armata Common Stock		97,549		—		—		97,549
Equity investment - Armata Warrants		—		47,148		—		47,148
Equity investment - InCarda Series C Preferred Stock						6,808		6,808
Equity investment - InCarda Preferred Stock Warrants						342		342
Convertible debt investment - Gate Note		—		—		15,200		15,200
Total assets measured at estimated fair value	$	558,819	$	47,148	$	24,403	$	630,370
Debt
2023 Notes	$	—	$	95,606	$	—	$	95,606
2025 Notes		—		214,443		—		214,443
2028 Notes		—		225,530		—		225,530
Total fair value of debt	$	—	$	535,579	$	—	$	535,579

(1)The investments held by ISP Fund LP, consisted of $201.6 million in equity investments, which included a private placement position of $2.1 million, $35.3 million in money market funds and $70.0 million in cash. Our total capital contribution of $300.0 million is subject to a 36-month lock-up period from the date of such capital contributions.

	Estimated Fair Value Measurements as of December 31, 2021 Using:
	Quoted Price
	in Active		Significant
	Markets for		Other		Significant
	Identical		Observable		Unobservable
Types of Instruments	Assets		Inputs		Inputs
(In thousands)	Level 1		Level 2		Level 3		Total
Assets
Money market funds	$	145,132	$	—	$	—	$	145,132
Investments held by ISP Fund LP (1)		193,677		—		2,068		195,745
Equity investment - Armata Common Stock		88,101		—		—		88,101
Equity investment - Armata Warrants		—		58,595		—		58,595
Equity investment - Entasis Common Stock		62,794		—		—		62,794
Equity investment - Entasis Warrants		—		40,914		—		40,914
Equity investment - InCarda Warrants		—		—		411		411
Convertible debt investment - Gate Note		—		—		15,100		15,100
Total assets measured at estimated fair value	$	489,704	$	99,509	$	17,579	$	606,792
Debt
2023 Notes	$	—	$	261,769	$	—	$	261,769
2025 Notes		—		234,498		—		234,498
Total fair value of debt	$	—	$	496,267	$	—	$	496,267

(1)The investments held by ISP Fund LP, consisted of $192.2 million equity investments and $3.5 million money market funds, are subject to a 36-month lock-up period from our initial contribution date, December 11, 2020.

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The fair values of our equity investments in Armata’s common stock and publicly traded investments held by ISP Fund LP are based on the quoted prices in active markets and are classified as Level 1 financial instruments. The fair values of the warrants of Armata classified within Level 2 are based upon observable inputs that may include benchmark yields, reported trades, broker/dealer quotes, issuer spreads, two-sided markets, benchmark securities, bids, offers, and reference data including market research publications.

InCarda’s equity securities, the Gate Convertible Note, and private placement positions held by ISP Fund LP are classified as Level 3 financial instruments as these securities are not publicly traded and the assumptions used in the valuation model for valuing these securities are based on significant unobservable and observable inputs including those of publicly traded peer companies.

The fair values of our 2023 Notes, 2025 Notes and 2028 Notes are based on recent trading prices of the respective instruments.

6. Goodwill and Intangible Assets

Goodwill and intangible assets acquired in our consolidation of Entasis were recognized at fair value as of the consolidation date, February 17, 2022. The carrying amount of goodwill as of June 30, 2022 was $5.5 million. Intangible assets with definite lives are amortized over their estimated useful lives. The carrying basis and accumulated amortization of recognized intangible assets as of June 30, 2022 were as follows:

	Carrying
(In thousands)	Amount
Intangible assets with indefinite life	$	69,500
Intangible asset with determinable life		35,500
Total	$	105,000

All intangible assets are related to in-process research and development. The intangible assets with indefinite life consist of antibacterial therapeutic products. The intangible asset with determinable life consists of a contract, which commences in 2023. The useful life of this intangible asset will be determined upon commercialization of the underlying product candidate. Thus, no amortization expense of determinable assets was recognized during the period ended June 30, 2022.

Goodwill and indefinite-lived intangible assets are not amortized but are tested at least annually for impairment, or more frequently if triggering events occur, based on the estimated fair value of the intangible asset.

7. Balance Sheet Components

Other Accrued Liabilities

Other accrued liabilities consisted of the following:

	June 30,		December 31,
(in thousands)	2022		2021
Accrued contract manufacturing	$	4,621	$	—
Accrued clinical		994		—
Accrued research		330		—
Accrued professional services		3,829		894
Current portion of lease liabilities		687		106
Liabilities for unsettled security transactions		6,328		—
Other		355		9
Total other accrued liabilities	$	17,144	$	1,009

The other accrued liabilities balance as of June 30, 2022 included $8.2 million related to Entasis.

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8. Stock-Based Compensation

Stock- Based Compensation Expense

The following table summarizes stock-based compensation expense, which included $0.7 million and $1.0 million, respectively, related to Entasis’ equity awards, for the three and six months ended June 30, 2022:

	Three Months Ended June 30,				Six Months Ended June 30,
(In thousands)	2022		2021		2022		2021
General and administrative	$	1,030	$	470	$	1,818	$	921
Research and development		320		—		486		—
Total	$	1,350	$	470	$	2,304	$	921

Valuation Assumptions

Black-Scholes-Merton assumptions used in calculating the estimated value of stock options granted by Innoviva on the date of grant were as follows:

	Three Months Ended June 30,						Six Months Ended June 30,
	2022			2021			2022			2021
Risk-free interest rate	2.84% - 3.03%			1.07%			1.6% - 3.03%			1.07% - 1.13%
Expected term (in years)	5.50 - 6.11				6.00		5.50 - 6.11				6.00
Volatility	38.8% - 39.0%				45.0	%	38.8% - 40.5%				45.0	%
Dividend yield		0.0	%		0.0	%		0.0	%		0.0	%
Weighted-average estimated fair value of stock options granted	$6.98 - $7.18			$	5.80		$6.98 - $7.73			$	5.61

9. Debt

Our debt consisted of the following:

	June 30,			December 31,
(In thousands)	2022			2021
2023 Notes	$	96,204		$	240,984
2025 Notes		192,500			192,500
2028 Notes		261,000			—
Total debt		549,704			433,484
Less: Unamortized debt discount and issuance costs		(10,454	)		(38,831	)
Total debt, net	$	539,250		$	394,653
Less: Current portion of long-term debt, net		96,072			—
Total long-term debt, net	$	443,178		$	394,653

Convertible Subordinated Notes Due 2023

In January 2013, we completed an underwritten public offering of $287.5 million aggregate principal amount of our 2023 Notes, which will mature on January 15, 2023. The financing raised proceeds, net of issuance costs, of approximately $281.2 million, less $36.8 million to purchase two privately negotiated capped call option transactions in connection with the issuance of the notes. The 2023 Notes bear interest at the rate of 2.125% per year that is payable semi-annually in arrears in cash on January 15 and July 15 of each year, beginning on July 15, 2013.

At the option of the holders, the 2023 Notes may be converted into fully paid and non-assessable shares of our common stock prior to the close of the business on the second business day immediately preceding the final maturity date. The initial conversion rate was 35.9903 shares per $1,000 principal amount of the 2023 Notes, subject to customary anti-dilution adjustment in certain circumstances, which represented an initial conversion price of approximately $27.79 per share.

In event of default or a fundamental change (as defined in the indenture governing the 2023 Notes), holders of the 2023 Notes may require us to repurchase all or a portion of their 2023 Notes at price equal to 100% of the principal amount of the 2023 Notes, plus any accrued and unpaid interest.

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In connection with the offering of the 2023 Notes, we entered into two privately negotiated capped call option transactions with a single counterparty. The capped call option transaction is an integrated instrument consisting of a call option on our common stock purchased by us with a strike price equal to the initial conversion price of $27.79 per share for the underlying number of shares and a cap price of $38.00 per share, both of which are subject to adjustments consistent with the 2023 Notes. The cap component is economically equivalent to a call option sold by us for the underlying number of shares with an initial strike price of $38.00 per share. As an integrated instrument, the settlement of the capped call coincides with the due date of the convertible debt. Upon settlement, we would receive from our hedge counterparty a number of shares of our common shares that would range from zero, if the stock price was below $27.79 per share, to a maximum of 2,779,659 shares, if the stock price is above $38.00 per share. However, if the market price of our common stock, as measured under the terms of the capped call transactions, exceeds $38.00 per share, there is no incremental anti-dilutive benefit from the capped call.

As a result of the partial conversion by certain holders of the 2023 Notes in July 2014, and dividends declared and paid in 2014 and 2015, the conversion rate with respect to our 2023 Notes was adjusted in total to 50.5818 shares of our common stock per $1,000 principal amount of the 2023 Notes, which represents a conversion price of approximately $19.77 per share. As a result of the conversion rate adjustments, the capped call strike price and cap price were also adjusted to $19.77 and $27.04, respectively.

During 2016, we retired a portion of our 2023 Notes with a face value of $14.1 million and carrying value of $13.9 million by way of purchase in the open market.

On March 7, 2022, we used $165.6 million from the sale of the 2028 Notes to repurchase 60% of the 2023 Notes with a face value of $144.8 million. The carrying value of the repurchased 2023 Notes was $144.5 million. Accrued interest was $0.4 million and unamortized debt issuance costs were $0.3 million on the date of repurchase. We recognized a loss on the extinguishment of the 2023 Notes of $20.7 million in other expense, net in the unaudited condensed consolidated statement of operations. The repurchase reduced the outstanding principal balance to $96.2 million and unamortized debt issuance costs to $0.2 million. The effective interest rate of the 2023 Notes changed to 2.37%.

On April 18, 2022, certain 2023 Notes holders converted their notes of $3.0 thousand into Innoviva’s common stock. The outstanding principal balance was reduced slightly to $96.2 million.

Our outstanding 2023 Notes balances consisted of the following:

	June 30,			December 31,
(In thousands)	2022			2021
Liability component
Principal	$	96,204		$	240,984
Debt issuance costs, net		(132	)		(620	)
Net carrying amount	$	96,072		$	240,364

The following table sets forth total interest expense recognized related to the 2023 Notes for the three and six months ended June 30, 2022 and 2021:

	Three Months Ended June 30,				Six Months Ended June 30,
(In thousands)	2022		2021		2022		2021
Contractual interest expense	$	511	$	1,280	$	1,595	$	2,560
Amortization of debt issuance costs		59		147		181		288
Total interest and amortization expense	$	570	$	1,427	$	1,776	$	2,848

Convertible Senior Notes Due 2025

On August 7, 2017, we completed a private placement of $192.5 million aggregate principal amount of our 2025 Notes. The proceeds include the 2025 Notes sold pursuant to the $17.5 million over-allotment option granted by us to the initial purchasers, which option was exercised in full. The 2025 Notes were sold in a private placement to qualified institutional buyers pursuant to Rule 144A under the Securities Act. The 2025 Notes are senior unsecured obligations and bear interest at a rate of 2.5% per year, payable semi-annually in arrears on February 15 and August 15 of each year, beginning on February 15, 2018.

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The 2025 Notes are convertible, based on the applicable conversion rate, into cash, shares of our common stock or a combination thereof, at our election. The initial conversion rate for the 2025 Notes is 57.9240 shares of our common stock per $1,000 principal amount of the 2025 Notes (which is equivalent to an initial conversion price of approximately $17.26 per share), representing a 30.0% conversion premium over the last reported sale price of the Company’s common stock on August 1, 2017, which was $13.28 per share. The conversion rate is subject to customary anti-dilution adjustments in certain circumstances. The 2025 Notes will mature on August 15, 2025, unless repurchased or converted in accordance with their terms prior to such date. Prior to February 15, 2025, the 2025 Notes will be convertible at the option of the holders only upon the occurrence of specified events and during certain periods, as described below. From, and including, February 15, 2025, until the close of business on the second scheduled trading day immediately preceding the maturity date, the 2025 Notes will be convertible at any time.

Holders of the 2025 Notes may convert all or a portion of their 2025 Notes prior to the close of business on February 15, 2025 only under the following circumstances:

•after September 30, 2017, if our closing common stock price for at least 20 days out of the most recent 30 consecutive trading days of the preceding quarter is greater than 130% of the current conversion price of the 2025 Notes;

•for five consecutive business days, if the average trading price per $1,000 of Notes during the prior 10 consecutive trading days is less than 98% of the product of the our closing common stock price and the conversion rate of the 2025 Notes on such day;

•upon the occurrence of specified corporate events, including certain distributions, the occurrence of a fundamental changes (as defined in the indenture governing the 2025 Notes) or a transaction resulting in our common stock converting into other securities or property or assets.

On or after February 15, 2025, holders of the 2025 Notes may convert their 2025 Notes at any time until the close of business on the second scheduled trading day immediately preceding the maturity date of the 2025 Notes.

In event of default or a fundamental change (as defined above), holders of the 2025 Notes may require us to repurchase all or a portion of their 2025 Notes at price equal to 100% of the principal amount of the 2025 Notes, plus any accrued and unpaid interest.

Effective January 1, 2022, we adopted ASU 2020-06 using a modified retrospective method, under which financial results reported in prior periods were not adjusted. The adoption of ASU 2020-06 had a material impact on the 2025 notes.

Prior to the adoption of the standard, we separately account for the liability and equity components of the 2025 Notes by allocating the proceeds between the liability component and the embedded conversion option (“equity component”) due to our ability to settle the conversion obligation of the 2025 Notes in cash, common stock or a combination of cash and common stock, at our option. The carrying amount of the liability component was calculated by measuring the fair value of a similar liability that does not have an associated convertible feature using the income approach. The allocation was performed in a manner that reflected our non-convertible debt borrowing rate for similar debt. The equity component of the 2025 Notes of $67.3 million was recognized as a debt discount and represents the difference between the proceeds from the issuance of the 2025 Notes and the fair value of the liability of the 2025 Notes on the date of issuance. The excess of the principal amount of the liability component over its carrying amount (“debt discount”) is amortized to interest expense using the effective interest method over the term of the 2025 Notes. The equity component is not remeasured as long as it continues to meet the conditions for equity classification. Additionally, we separated the total issuance costs of $5.4 million incurred into liability and equity components in proportion to the allocation of the initial proceeds, resulting in liability issuance costs of $3.5 million and equity issuance costs of $1.9 million. Issuance costs attributable to the liability component were amortized on a straight-line basis, which approximated the effective interest rate method, to interest expense over the term of the 2025 Notes. The issuance costs attributable to the equity component were netted against the equity component in additional paid-in capital. The effective interest rate of the liability component of the 2025 Notes was 8.87%.

Upon adoption of ASU 2020-06 on January 1, 2022, we combined the liability and equity components of the 2025 Notes assuming that the instrument was accounted for as a single liability from inception to the date of adoption. We similarly combined the liability and equity components of the issuance costs. The issuance costs are presented as a deduction from the outstanding principal balance of the 2025 Notes, and are amortized on a straight-line basis over the term of the 2025 Notes under the effective interest rate method. As of January 1, 2022, the effective interest rate on the 2025 Notes was 2.88%.

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Our outstanding 2025 Notes balances consisted of the following:

	June 30,			December 31,
(In thousands)	2022			2021
Liability component
Principal	$	192,500		$	192,500
Debt discount and issuance costs, net		(2,265	)		(38,211	)
Net carrying amount	$	190,235		$	154,289
Equity component, net	$	—		$	65,361

The following table sets forth total interest expense recognized related to the 2025 Notes for the three and six months ended June 30, 2022 and 2021:

	Three Months Ended June 30,				Six Months Ended June 30,
(In thousands)	2022		2021		2022		2021
Contractual interest expense	$	1,203	$	1,203	$	2,406	$	2,406
Amortization of debt issuance costs		172		162		343		321
Amortization of debt discount		—		1,951		—		3,862
Total interest and amortization expense	$	1,375	$	3,316	$	2,749	$	6,589

Convertible Senior Notes Due 2028

In March 2022, we completed a private placement of $261.0 million aggregate principal amount of our 2028 Notes, which will mature on March 15, 2028. The proceeds include the 2028 Notes sold pursuant to the $45.0 million over-allotment option granted by us to the initial purchasers, of which $36.0 million was exercised. The 2028 Notes were sold in a private placement to qualified institutional buyers pursuant to Rule 144A under the Securities Act.

The net proceeds from the sale of the $261.0 million aggregate principal amount of 2028 Notes were approximately $252.6 million after deducting the initial purchasers’ discounts and commissions and our estimated offering expenses. We used approximately $21.0 million of the net proceeds from the offering to fund the cost of entering into the capped call transactions described below. In addition, we used $165.6 million of the remaining net proceeds to repurchase $144.8 million aggregate principal amount of the 2023 Notes in separate and individually negotiated transactions with certain holders of the 2023 Notes, which closed concurrently with the issuance of the 2028 Notes. We expect to use the remaining net proceeds for general corporate purposes.

The 2028 Notes bear interest at an annual rate of 2.125% that is payable semi-annually in arrears in cash on March 15 and September 15 of each year, beginning on September 15, 2022.

The 2028 Notes are convertible, based on the applicable conversion rate, into cash, shares of our common stock or a combination thereof, at our election. The initial conversion rate was 38.1432 shares per $1,000 principal amount of the 2028 Notes, subject to customary anti-dilution adjustment in certain circumstances, which represented an initial conversion price of approximately $26.22 per share.

Prior to September 15, 2027, the 2028 Notes will be convertible at the option of the holders only upon the occurrence of specified events and during certain periods, and will be convertible on or after September 15, 2027, at any time until the close of business on the second scheduled trading day immediately preceding the maturity date of the Notes.

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Holders of the 2028 Notes may convert all or a portion of their 2028 Notes prior to the close of business on September 15, 2027, only under the following circumstances:

•after March 31, 2022, if our closing common stock price for at least 20 days out of the most recent 30 consecutive trading days of the preceding quarter is greater than 130% of the current conversion price of the 2028 Notes;

•for five consecutive business days, if the average trading price per $1,000 of Notes during the prior 10 consecutive trading days is less than 98% of the product of our closing common stock price and the conversion rate of the 2028 Notes on such day;

•upon the occurrence of specified corporate events, including certain distributions, the occurrence of a fundamental changes (as defined in the indenture governing the 2028 Notes) or a transaction resulting in our common stock converting into other securities or property or assets.

On or after September 15, 2027, holders of the 2028 Notes may convert their 2028 Notes at any time until the close of the business on the second day immediately preceding the maturity date of the 2028 Notes.

The 2028 Notes will be redeemable, in whole or in part, at our option at any time, and from time to time, on or after March 20, 2025, and on or before the 75th scheduled trading day immediately before the maturity date but only if the last reported sale price per share of our common stock exceeds 130% of the conversion price for a specified period of time. The redemption price will be equal to the principal amount of the 2028 Notes to be redeemed, plus accrued and unpaid interest, if any, to, but excluding, the redemption date. In addition, calling any 2028 Note for redemption will constitute a make-whole fundamental change (as defined in the indenture governing the 2028 Notes) with respect to that 2028 Note, in which case the conversion rate applicable to the conversion of that 2028 Note will be increased in certain circumstances if it is converted after it is called for redemption.

If we undergo a fundamental change, subject to certain conditions, holders may require us to purchase for cash all or any portion of their 2028 Notes. The fundamental change purchase price will be 100% of the principal amount of the 2028 Notes to be purchased plus any accrued and unpaid interest to, but excluding, the fundamental change purchase date.

The indenture governing the 2028 Notes contains customary terms and covenants, including a merger covenant and that upon certain events of default occurring and continuing, either the Trustee or the holders of at least 25% of the aggregate principal amount of the outstanding Notes may declare 100% of the principal of, and accrued and unpaid interest, if any, on, all the Notes to be due and payable immediately.

In connection with the offering of the 2028 Notes, we entered into privately negotiated capped call transactions. The cap price of the capped call transaction is initially $33.9850 per share and is subject to certain adjustments under the terms of the capped call transactions. The capped call transactions cover, subject to customary adjustments, the number of shares of common stock initially underlying the 2028 Notes. The capped call transactions are expected generally to reduce potential dilution to our common stock upon conversion of the 2028 Notes or at our election (subject to certain conditions) offset any cash payments we are required to make in excess of the aggregate principal amount of converted 2028 Notes, as the case may be, with such reduction or offset subject to a cap.

As of June 30, 2022, the effective interest rate on the 2028 Notes was 2.70%.

Our outstanding 2028 Notes balance as of June 30, 2022 consisted of the following:

(In thousands)	June 30, 2022
Liability component
Principal	$	261,000
Debt issuance costs, net		(8,057	)
Net carrying amount	$	252,943

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The following table sets forth total interest expense recognized related to the 2028 Notes from the date of issuance through June 30, 2022:

	Three Months Ended June 30,		Six Months Ended June 30,
(In thousands)	2022		2022
Contractual interest expense	$	1,387	$	1,756
Amortization of debt issuance costs		323		407
Total interest and amortization expense	$	1,710	$	2,163

Debt Maturities

The aggregate scheduled maturities of our convertible debt as of June 30, 2022 were as follows:

(In thousands)	June 30, 2022
Years ending December 31:
Remainder of 2022	$	—
2023		96,204
2024		—
2025		192,500
2026		—
Thereafter		261,000
Total	$	549,704

10. Commitments and Contingencies

Operating Lease

Our operating leases include Entasis’ facility lease (the “Entasis Lease”) consisting of 20,062 square feet of office and laboratory space in Waltham, Massachusetts. In February 2022, Entasis decided to exercise a renewal option for the Entasis Lease to extend the lease term for three additional years through 2025 and subsequently signed the Second Amendment in April 2022. As of June 30, 2022, the weighted average remaining lease term was 2.8 years and the estimated weighted-average incremental borrowing rate used to determine the operating lease right-of-use assets and lease liabilities was 7.8%.

We also lease approximately 2,111 square feet of office space in Burlingame, California.

The following table summarizes our operating leases as presented in the unaudited condensed consolidated balance sheets:

	June 30,		December 31,
(In thousands)	2022		2021
Assets
Right-of-use assets	$	3,545	$	97
Liabilities
Lease liabilities, current	$	687	$	106
Lease liabilities, long-term		3,091		—
Total lease liabilities	$	3,778	$	106

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Future minimum operating lease payments on the Entasis Lease as of June 30, 2022 were as follows:

(In thousands)	June 30, 2022
Years ending December 31:
Remainder of 2022	$	368
2023		1,249
2024		1,269
2025		1,289
Total undiscounted lease payments		4,175
Less: imputed interest		(442	)
Total operating lease liabilities	$	3,733

Future minimum operating lease payments on our corporate headquarters in Burlingame, California as of June 30, 2022 were as follows:

(In thousands)	June 30, 2022
Years ending December 31:
Remainder of 2022	$	46
Thereafter		—
Total	$	46

Legal Proceedings

From time to time, the Company is involved in legal proceedings in the ordinary course of its business. Currently, we believe that no litigation or arbitration, either individually or in the aggregate, to which we are presently a party is likely to have a material adverse effect on our operating results or financial position.

11. Income Taxes

We recorded a provisional income tax benefit of $0.9 million for the three months ended June 30, 2022 and provisional income tax expense of $6.0 million for the six months ended June 30, 2022, compared to provisional income tax expense of $25.3 million and $45.1 million for the three and six months ended June 30, 2021 respectively. The Company’s effective income tax rate for the six months ended June 30, 2022 was 4.3%, compared to 18.6% for the same period in 2021. The income tax expense for the six months ended June 30, 2022 and 2021 was determined based upon estimates of the Company’s effective income tax rates in various jurisdictions. Our effective income tax rate for the six months ended June 30, 2022 was lower than the U.S. federal statutory income tax rate due primarily to noncontrolling interest and a decrease in the fair value of our equity investments.

12. Subsequent Events

On July 11, 2022, we announced the completion of our acquisition of Entasis by acquiring all the issued and outstanding equity securities of Entasis not already owned by our company for $2.20 per share for a consideration of $42.4 million.

On July 11, 2022, we also entered into a definitive merger agreement, whereby we will acquire La Jolla Pharmaceutical Company (“La Jolla”), a company dedicated to the commercialization of innovative therapies that improve outcomes in patients suffering from life-threatening diseases. Under the terms of the agreement, we will acquire all of the outstanding shares of La Jolla for $6.23 per share in cash subject to certain closing conditions.

On July 13, 2022, we announced that we entered into an agreement to sell our 15% economic stake in TRC, which receives royalties stemming from sales of TRELEGY® ELLIPTA®, to Royalty Pharma plc for an upfront cash payment of approximately $282.0 million and a potential $50.0 million contingent sales-based milestone payment. Under the terms of the agreement, TRC also transferred to Innoviva all of TRC's ownership interests and investments in InCarda, ImaginAb, Gate Neurosciences and Nanolive. We retain our royalty rights with respect to RELVAR®/BREO® ELLIPTA® and ANORO® ELLIPTA®, as well as the GSK Agreements associated with the retained products. The transaction was closed on July 20, 2022.

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Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations

Forward-Looking Statements

The information in this Quarterly Report on Form 10-Q contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended (“Securities Act”), and Section 21E of the Securities Exchange Act of 1934, as amended. Such forward-looking statements involve substantial risks, uncertainties, and assumptions. All statements contained herein that are not of historical fact, including, without limitation, statements regarding our strategy, future operations, future financial position, future revenue, projected costs, prospects, plans, intentions, expectations, goals and objectives, may be forward-looking statements. The words “anticipates,” “believes,” “could,” “designed,” “estimates,” “expects,” “goal,” “intends,” “may,” “objective,” “plans,” “projects,” “pursue,” “will,” “would” and similar expressions (including the negatives thereof) are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. We may not actually achieve the plans, intentions, expectations or objectives disclosed in our forward-looking statements and the assumptions underlying our forward-looking statements may prove incorrect. Therefore, you should not place undue reliance on our forward-looking statements. Actual results or events could differ materially from the plans, intentions, expectations and objectives disclosed in the forward-looking statements that we make. All written and verbal forward-looking statements attributable to us or any person acting on our behalf are expressly qualified in their entirety by the cautionary statements contained or referred to in this section. Important factors that we believe could cause actual results or events to differ materially from our forward-looking statements include, but are not limited to, risks related to: lower than expected future royalty revenue from respiratory products partnered with GSK; the commercialization of RELVAR®/BREO® ELLIPTA®, ANORO® ELLIPTA® and TRELEGY® ELLIPTA® in the jurisdictions in which these products have been approved; substantial competition from products discovered, developed, launched and commercialized both by GSK and by other pharmaceutical companies; the strategies, plans and objectives of the Company (related to the Company’s growth strategy and corporate development initiatives beyond the Company’s existing portfolio); the timing, manner and amount of capital deployment, including potential capital returns to stockholders; risks related to the Company’s growth strategy; projections of revenue, expenses and other financial items and risks discussed in “Risk Factors” in Item 1A of Part I of our Annual Report on Form 10-K for the year ended December 31, 2021 filed with the Securities and Exchange Commission (“SEC”) on February 28, 2022, and as amended on March 17, 2022 (“2021 Form 10-K”), and Item 1A of Part II of our Quarterly Reports on Form 10-Q and below in “Management’s Discussion and Analysis of Financial Condition and Results of Operations” in this Item 2 of Part I. All forward-looking statements in this Quarterly Report on Form 10-Q are based on current expectations as of the date hereof and we do not assume any obligation to update any forward-looking statements on account of new information, future events or otherwise, except as required by law.

We encourage you to read our unaudited condensed consolidated financial statements contained in this Quarterly Report on Form 10-Q. We also encourage you to read Item 1A of Part I of our 2021 Form 10-K and Item 1A of Part II of our Quarterly Reports on Form 10-Q entitled “Risk Factors,” which contain a more complete discussion of the risks and uncertainties associated with our business. In addition to the risks described above and in Item 1A of Part I of our 2021 Form 10-K and Item 1A of Part II of this report, other unknown or unpredictable factors also could affect our results. Therefore, the information in this report should be read together with other reports and documents that we file with the SEC from time to time, including on Form 10-K, Form 10-Q and Form 8-K, which may supplement, modify, supersede or update those risk factors. As a result of these factors, we cannot assure you that the forward-looking statements in this report will prove to be accurate. Furthermore, if our forward-looking statements prove to be inaccurate, the inaccuracy may be material. In light of the significant uncertainties in these forward-looking statements, you should not regard these statements as a representation or warranty by us or any other person that we will achieve our objectives and plans in any specified time frame, or at all.

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OVERVIEW

Executive Summary

Innoviva, Inc. (“Innoviva”, the “Company”, the “Registrant” or “we” and other similar pronouns) is a company with a portfolio of royalties and other healthcare assets. Our royalty portfolio contains respiratory assets partnered with Glaxo Group Limited (“GSK”), including RELVAR®/BREO® ELLIPTA® (fluticasone furoate/ vilanterol, “FF/VI”), ANORO® ELLIPTA® (umeclidinium bromide/ vilanterol, “UMEC/VI”) and TRELEGY® ELLIPTA® (the combination FF/UMEC/VI). Under the Long-Acting Beta2 Agonist (“LABA”) Collaboration Agreement, Innoviva is entitled to receive royalties from GSK on sales of RELVAR®/BREO® ELLIPTA® as follows: 15% on the first $3.0 billion of annual global net sales and 5% for all annual global net sales above $3.0 billion; and royalties from the sales of ANORO® ELLIPTA®, which tier upward at a range from 6.5% to 10%. Innoviva is also entitled to 15% of royalty payments made by GSK under its agreements originally entered into with us, and since assigned to Theravance Respiratory Company, LLC (“TRC”), including TRELEGY® ELLIPTA® and any other product or combination of products that may be discovered or developed in the future under the LABA Collaboration Agreement and the Strategic Alliance Agreement with GSK (referred to herein as the “GSK Agreements”), which have been assigned to TRC other than RELVAR®/BREO® ELLIPTA® and ANORO® ELLIPTA®.

Our company structure and organization are tailored to our focused activities of managing our respiratory assets partnered with GSK, including the commercial and developmental obligations associated with the GSK Agreements, optimizing capital allocation and providing for certain essential reporting and management functions of a public company. Our revenues consist of royalties from our respiratory partnership agreements with GSK.

Recent Highlights

•GSK Net Sales:

•Second quarter 2022 net sales of RELVAR®/BREO® ELLIPTA® by GSK were $395.5 million, down 10% from $439.5 million in the same quarter of 2021, with $189.7 million in net sales from the U.S. market and $205.8 million from non-U.S. markets.

•Second quarter 2022 net sales of ANORO® ELLIPTA® by GSK were $148.2 million, down 19% from $184.0 million in the same quarter of 2021, with $74.5 million net sales from the U.S. market and $73.7 million from non-U.S. markets.

•Second quarter 2022 net sales of TRELEGY® ELLIPTA® by GSK were $590.1 million, up 45% from $405.9 million in the same quarter of 2021, with $449.1 million in net sales from the U.S. market and $141.0 million in net sales from non-U.S. markets.

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•Capital Allocations:

•During the second quarter of 2022, the Company’s wholly owned subsidiary, Innoviva Strategic Opportunities LLC, announced the purchase of all the issued and outstanding equity securities of Entasis Therapeutics not already owned by Innoviva and its affiliates for $2.20 per share for a consideration of $42.4 million. The purchase closed on July 11, 2022.

•Subsequent to the close of the second quarter of 2022, the Company’s wholly owned subsidiary, Innoviva Strategic Opportunities LLC, entered into a definitive merger agreement to acquire La Jolla Pharmaceutical Company (Nasdaq: LJPC). Innoviva has agreed to pay $5.95 per share and an incremental $0.28 per share for additional cash proceeds received in connection with the divestiture of a non-core asset. The implied enterprise value of La Jolla was approximately $149.0 million. The acquisition is expected in to close later in the third quarter of 2022.

•In July, the Company sold its 15% stake in Theravance Respiratory Company (“TRC”), which received royalties stemming from sales of TRELEGY® ELLIPTA®, to Royalty Pharma plc (Nasdaq: RPRX) for an upfront cash payment of approximately $282.0 million and a potential $50.0 million contingent sales-based milestone payment. Under the terms of the agreement, TRC also transferred to Innoviva all of TRC’s ownership interests and investments in InCarda Therapeutics Inc., ImaginAb, Inc., Gate Neurosciences, Inc. and Nanolive SA; collectively, these ownership interests are valued at $42.5 million as of quarter-end. Innoviva retained its royalty rights with respect to ANORO® ELLIPTA® and RELVAR®/BREO® ELLIPTA®.

Collaborative Arrangements with GSK

LABA Collaboration

In November 2002, we entered into the LABA collaboration with GSK to develop and commercialize once-daily LABA products for the treatment of chronic obstructive pulmonary disorder (“COPD”) and asthma (the “LABA Collaboration Agreement”). For the treatment of COPD, the collaboration has developed three combination products:

•RELVAR®/BREO® ELLIPTA® (“FF/VI”) (BREO® ELLIPTA® is the proprietary name in the U.S. and Canada and RELVAR® ELLIPTA® is the proprietary name outside the U.S. and Canada), a once-daily combination medicine consisting of a LABA, vilanterol (VI), and an inhaled corticosteroid (“ICS”), fluticasone furoate (“FF”),

•ANORO® ELLIPTA® (“UMEC/VI”), a once-daily medicine combining a long-acting muscarinic antagonist (“LAMA”), umeclidinium bromide (“UMEC”), with a LABA, vilanterol (VI), and

•TRELEGY® ELLIPTA® (the combination FF/UMEC/VI), a once-daily combination medicine consisting of an ICS, LAMA and LABA.

As a result of the launch and approval of RELVAR®/BREO® ELLIPTA® and ANORO® ELLIPTA® in the U.S., Japan and Europe, in accordance with the LABA Collaboration Agreement, we paid milestone fees to GSK totaling $220.0 million during the year ended December 31, 2014. Although we have no further milestone payment obligations to GSK pursuant to the LABA Collaboration Agreement, we continue to have ongoing commercialization activities under the LABA Collaboration Agreement, including participation in the joint steering committee and joint project committee that are expected to continue over the life of the agreement. The milestone fees paid to GSK were recognized as capitalized fees paid to a related party, which are being amortized over their estimated useful lives commencing upon the commercial launch of the products.

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Critical Accounting Policies and Estimates

Our management’s discussion and analysis of our financial condition and results of operations is based on our financial statements, which have been prepared in accordance with accounting principles generally accepted in the United States of America (“US GAAP”). The preparation of these financial statements requires us to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities as of the date of the financial statements, as well as the reported revenue generated and expenses incurred during the reporting periods. Our estimates are based on our historical experience and on various other factors that we believe are reasonable under the circumstances, the results of which form the basis for making judgments about the carrying value of assets and liabilities that are not readily apparent from other sources. Actual results may differ from these estimates under different assumptions or conditions. Other than those set out in Note 1 to our accompanying unaudited condensed consolidated financial statements, we believe there have been no significant changes in our critical accounting policies as described in the Form 10-K for the year ended December 31, 2021 filed with the SEC on February 28, 2022, and as amended on March 17, 2022.

Results of Operations

Net Revenue

Total net revenue, as compared to the prior year period, was as follows:

	Three Months Ended June 30,						Change						Six Months Ended June 30,						Change
(In thousands)	2022			2021			$			%			2022			2021			$			%
Royalties from a related party    - RELVAR/BREO	$	59,326		$	65,916		$	(6,590	)		(10	)%	$	115,090		$	122,306		$	(7,216	)		(6	)%
Royalties from a related party    - ANORO		9,630			11,960			(2,330	)		(19	)%		18,072			22,460			(4,388	)		(20	)%
Royalties from a related party    - TRELEGY		42,720			26,386			16,334			62	%		72,029			48,470			23,559			49	%
Total royalties from a related party		111,676			104,262			7,414			7	%		205,191			193,236			11,955			6	%
Less: amortization of capitalized fees    paid to a related party		(3,456	)		(3,456	)		—		*				(6,912	)		(6,912	)		—		*
Royalty revenue from GSK	$	108,220		$	100,806		$	7,414			7	%	$	198,279		$	186,324		$	11,955			6	%

*Not Meaningful

Total net revenue increased to $108.2 million and $198.3 million for the three and six months ended June 30, 2022, compared to $100.8 million and $186.3 million, respectively, for the same period a year ago, primarily due to growth in prescriptions for our TRELEGY products.

Research & Development

Research and development (“R&D”) expenses attributable to Entasis’ product development efforts were $13.9 million and $19.7 million, respectively, for the three and six months ended June 30, 2022. Research and development expenses for the three and six months ended June 30, 2021 were attributable to the product development of Pulmoquine Therapeutics Inc., which was dissolved at the end of 2021.

General & Administrative

General and administrative expenses, as compared to the prior year period, were as follows:

	Three Months Ended June 30,				Change					Six Months Ended June 30,				Change
(In thousands)	2022		2021		$		%			2022		2021		$		%
General and administrative	$	11,782	$	4,228	$	7,554		179	%	$	18,274	$	10,214	$	8,060		79	%

General and administrative expenses for the three and six months ended June 30, 2022 increased compared to the same period in 2021 mainly due to the consolidation of Entasis’ operating expenses starting February 17, 2022.

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Interest and dividend income and other expense, net

Interest and dividend income and other expense, net, as compared to the prior year period, were as follows:

	Three Months Ended June 30,						Change					Six Months Ended June 30,						Change
(In thousands)	2022			2021			$		%			2022			2021			$		%
Interest and dividend income	$	724		$	20		$	704	*			$	1,046		$	50		$	996	*
Other expense, net		(528	)		(951	)		423		(44	)%		(778	)		(1,384	)		606		(44	)%

*Not Meaningful

Interest and dividend income increased for the three and six months ended June 30, 2022 compared to the same periods a year ago due to higher returns on investments, including those managed by ISP Fund LP.

Other expense, net, was primarily expenses incurred by ISP Fund LP. Other expense, net was partially offset by income from grants of $0.4 million and $0.7 million during the three and six months ended June 30, 2022. There was no income from grants during 2021.

Interest Expense

Interest expense, as compared to the prior year period, was as follows:

	Three Months Ended June 30,				Change						Six Months Ended June 30,				Change
(In thousands)	2022		2021		$			%			2022		2021		$			%
Interest expense	$	3,655	$	4,745	$	(1,090	)		(23	)%	$	6,665	$	9,439	$	(2,774	)		(29	)%

The decrease in interest expense was primarily due to the adoption of the new accounting standard, ASU 2020-06, which is to simplify the accounting for convertible debt instruments, and the debt discount associated with the cash settlement feature of our convertible notes due 2025 (“2025 Notes”), which was adjusted to zero as of January 1, 2022. The interest expense for the three and six months ended June 30, 2022 included the contractual interest expense and the amortization of debt issuance costs for our 2023 Notes, 2025 Notes and 2028 Notes. Interest expense for the three and six months ended June 30, 2021 included the contractual interest expense, the amortization of debt discount and issuance costs for our 2023 Notes and 2025 Notes.

Loss on Debt Extinguishment

We recognized a loss of $20.7 million due to the total premium payment of $20.4 million and the write-off of $0.3 million debt issuance costs in connection with the repurchase of $144.8 million aggregate principal amount of our 2023 Notes in March 2022.

Changes in Fair Values of Equity and Long-Term Investments

Changes in fair values of equity and long-term investments, as compared to the prior year period, were as follows:

	Three Months Ended June 30,					Change						Six Months Ended June 30,					Change
(In thousands)	2022			2021		$			%			2022			2021		$			%
Changes in fair values of equity and    long-term investments, net	$	(58,600	)	$	45,315	$	(103,915	)		(229	)%	$	(68,011	)	$	100,360	$	(168,371	)		(168	)%

The changes in fair values of equity and long-term investments for the three and six months ended June 30, 2022 decreased compared to the same period in 2021 mainly due to the volatility in the capital markets. The changes in fair values of equity and long-term investments reflect the realized gains and losses and net unrealized gains and losses in our strategic investments in Armata, InCarda, Gate, and those investments managed by ISP Fund LP.

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Provision for Income Taxes

We recorded a provisional income tax benefit of $0.9 million for the three months ended June 30, 2022 and provisional income tax expense of $6.0 million for the six months ended June 30, 2022, compared to provisional interest tax expense of $25.3 million and $45.1 million for the three and six months ended June 30, 2021. The effective income tax rate for the six months ended June 30, 2022 and 2021 was 4.3% and 18.6%, respectively.

Net Income Attributable to Noncontrolling Interest

Net income attributable to noncontrolling interest, as compared to the prior periods, was as follows:

	Three Months Ended June 30,				Change						Six Months Ended June 30,				Change
(In thousands)	2022		2021		$			%			2022		2021		$		%
Net income attributable to    noncontrolling interest	$	20,432	$	21,898	$	(1,466	)		(7	)%	$	42,517	$	37,470	$	5,047		13	%

Net income attributable to noncontrolling interest represents $28.3 million and $53.4 million for the 85% share of net income in Theravance Respiratory Company, LLC for Theravance Biopharma and $7.9 million and $10.9 million for the 40% share of net loss in Entasis Therapeutics Holdings, Inc. for the three and six months ended June 30, 2022, respectively. The net income attributable to noncontrolling interest for the three and six months ended June 30, 2021 represents the 85% share of net income in Theravance Respiratory Company, LLC for Theravance Biopharma.

Liquidity and Capital Resources

Liquidity

Since our inception, we have financed our operations primarily through private placements and public offerings of equity and debt securities and payments received under collaborative arrangements. For the six months ended June 30, 2022, we generated gross royalty revenues from GSK of $205.2 million. Net cash and cash equivalents totaled $283.6 million, inclusive of $22.4 million of Entasis’ cash balance, and receivables from GSK totaled $111.7 million as of June 30, 2022.

Adequacy of Cash Resources to Meet Future Needs

We believe that cash from projected future royalty revenues and our cash, cash equivalents and marketable securities will be sufficient to meet our anticipated debt service and operating needs for at least the next 12 months based upon current operating plans and financial forecasts. If our current operating plans and financial forecasts change, we may require additional funding sooner in the form of public or private equity offerings or debt financings. Furthermore, if in our view favorable financing opportunities arise, we may seek additional funding at any time. However, future financing may not be available in amounts or on terms acceptable to us, if at all. This could leave us without adequate financial resources to fund our operations as currently planned. In addition, from time to time we may restructure or reduce our debt, including through tender offers, redemptions, amendments, repurchases or otherwise, all allowable with the terms of our debt agreements.

Cash Flows

Cash flows, as compared to the prior year period, were as follows:

	Six Months Ended June 30,
(In thousands)	2022			2021			Change
Net cash provided by operating activities	$	177,137		$	168,721		$	8,416
Net cash provided by (used in) investing activities		(145,678	)		63,627			(209,305	)
Net cash provided by (used in) financing activities		50,596			(435,570	)		486,166

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Cash Flows from Operating Activities

Net cash provided by operating activities for the six months ended June 30, 2022 was $177.1 million, consisting primarily of our net income of $59.2 million, adjusted for net non-cash items such as $6.0 million of deferred income tax, $7.1 million of depreciation and amortization, $20.7 million of loss on extinguishment of debt, and $68.0 million decrease in the fair value of our equity and long-term investments, offset by $6.9 million of accrued personnel-related expenses and other accrued liabilities, $3.0 million of prepaid expenses and $2.7 million of accounts payable.

Net cash provided by operating activities for the six months ended June 30, 2021 was $168.7 million, consisting primarily of our net income of $220.5 million, adjusted for net non-cash items such as $45.1 million of deferred income taxes, $6.9 million of depreciation and amortization, and $4.5 million of amortization of debt discount and issuance costs, partially offset by an increase of $99.0 million in the fair value of our equity and long-term investments, net and an increase in receivables from collaborative arrangements of $10.3 million.

Cash Flows from Investing Activities

Net cash used in investing activities for the six months ended June 30, 2022 of $145.7 million was primarily due to $38.0 million of purchases of equity investments managed by ISP Fund LP, $96.3 million of purchases and sales of other investments managed by ISP Fund LP, net, and $58.7 million investments in Armata, InCarda, and Nanolive, partially offset by $24.3 million of sales of equity investments managed by ISP Fund LP and $23.1 million of cash acquired through the consolidation of Entasis.

Net cash provided by investing activities for the six months ended June 30, 2021 of $63.6 million was due to $18.5 million of sales of equity investments managed by ISP Fund LP and $234.1 million of purchase and sales of other investments managed by ISP Fund LP, net partially offset by $142.6 million of purchases of equity investments managed by ISP Fund LP and $46.4 million investments in Armata, ImaginAb and Entasis.

Cash Flows from Financing Activities

Net cash provided by financing activities for the six months ended June 30, 2022 of $50.6 million was primarily due to the net proceeds of $252.5 million from the issuance of the convertible senior notes due in 2028, net of issuance costs, offset with $21.0 million purchase of capped call options associated with the 2028 Notes, $165.1 million for the repurchase of the 2023 Notes, and $16.1 million distributions to noncontrolling interest.

Net cash used in financing activities for the six months ended June 30, 2021 of $435.6 million was primarily due to $394.1 million used for our common stock repurchase from GSK and $41.4 million distributions to noncontrolling interest.

Contractual Obligations

In March 2022, we completed a private placement of $261.0 million aggregate principal amount of unsecured convertible senior notes, the 2028 Notes, which will mature on March 15, 2028. Under the terms of the 2028 Notes, we will make interest payments of approximately $2.9 million during the year 2022 and $5.5 million in each of the years from 2023 through 2027. The principal balance of $261.0 million will become due in March 2028. As of March 31, 2022, our notes payable obligation also included $96.2 million related to our 2023 Notes which are due in 2023 and $192.5 million related to our 2025 Notes which are due in 2025. Refer to Note 8, “Debt”, to the Condensed Consolidated Financial Statements for more information.

During the six months ended June 30, 2022, we determined that we have both (1) the power to direct the economically significant activities of Entasis and (2) the obligation to absorb the losses, or the right to receive the benefits, that could potentially be significant to Entasis, and therefore, we are the primary beneficiary of Entasis. Accordingly, we consolidated Entasis’ financial position and results of operations effective on February 17, 2022. In connection with the consolidation, we assumed contractual obligations related to an operating lease of Entasis for office and laboratory space in Waltham, Massachusetts with an expiration date in 2025. As of June 30, 2022, total undiscounted future minimum lease payments related to the Entasis lease were $4.2 million, with approximately $0.4 million payable through December 31, 2022 and approximately $1.3 million payable in each of the years from 2023 to 2025. Refer to Note 9, “Commitments and Contingencies”, to the Condensed Consolidated Financial Statements for more information.

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Item 3. Quantitative and Qualitative Disclosure about Market Risk

There have been no significant changes in our market risk or how our market risk is managed compared to those disclosed in our Annual Report on Form 10-K for the year ended December 31, 2021.

Item 4. Controls and Procedures

Evaluation of Disclosure Controls and Procedures.

We conducted an evaluation as of June 30, 2022, under the supervision and with the participation of our management, of the effectiveness of the design and operation of our disclosure controls and procedures, which are defined under SEC rules as controls and other procedures of a company that are designed to ensure that information required to be disclosed by a company in the reports that it files under the Securities Exchange Act of 1934 (“Exchange Act”) is recorded, processed, summarized and reported within required time periods. Based upon that evaluation, our Chief Executive Officer and Chief Accounting Officer, concluded that, as of such date, our disclosure controls and procedures were effective at the reasonable assurance levels.

Limitations on the Effectiveness of Controls

Our management does not expect that our disclosure controls and procedures or our internal control over financial reporting will prevent all errors and all frauds. A control system, no matter how well conceived and operated, can provide only reasonable, not absolute, assurance that the objectives of the control system are met. Further, the design of a control system must reflect the fact that there are resource constraints, and the benefit of controls must be considered relative to their costs. Because of the inherent limitations in all control systems, no evaluation of controls can provide absolute assurance that all control issues and instances of fraud, if any, within Innoviva have been detected. Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate.

Changes in Internal Control over Financial Reporting

There have been no material changes in our internal control over financial reporting (as defined in Rule 13a-15(f) of the Exchange Act) during the quarter ended June 30, 2022 that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

PART II. OTHER INFORMATION

Item 1. Legal Proceedings

There have not been any material changes to our legal proceedings from those reported in our fiscal year 2021 Annual Report on Form 10-K filed with the SEC.

Item 1A. Risk Factors

The information presented below supplements the risk factors set forth in Item 1A of Part I of our 2021 Form 10-K. As previously disclosed, on July 11, 2022, we announced the completion of our acquisition of Entasis by acquiring all the issued and outstanding equity securities of Entasis not already owned by our company for $2.20 per share. The Entasis business constitutes a significant portion of our business and additional significant risks may apply to the Entasis business as detailed in the Annual Report on Form 10-K filed by Entasis on March 3, 2022, and as amended on May 2, 2022, which are hereby incorporated by reference.

On July 11, 2022, we also entered into a definitive merger agreement, whereby we will acquire La Jolla. Additional risks regarding the La Jolla business are detailed in La Jolla's Form 10-K filed on March 9, 2022, and as amended on May 2, 2022. In the event our acquisition of La Jolla is ultimately consummated, certain risks detailed therein may apply to us.

Item 2. Unregistered Sales of Equity Securities and Use of Proceeds

None.

38

Item 3: Defaults Upon Senior Securities

None.

Item 4: Mine Safety Disclosures

None.

Item 5: Other Information

None.

39

Item 6. Exhibits

(a)Index to Exhibits

		Incorporated by Reference
Exhibit Number	Description	Form	Exhibit	Filing Date/Period End Date
2.1	Agreement and Plan of Merger, dated as of May 23, 2022, by and among Innoviva, Inc., Innoviva Merger Sub, Inc. and Entasis Therapeutics Holdings Inc.	8-K	2.1	5/24/2022
2.2	Agreement and Plan of Merger, dated as of July 10, 2022, by and among Innoviva, Inc., Innoviva Acquisition Sub, Inc. and La Jolla Pharmaceutical Company	8-K	2.1	7/11/2022
3.1	Amended and Restated Certificate of Incorporation	S-1	3.3	7/26/2004
3.2	Certificate of Amendment of Restated Certificate of Incorporation	10-Q	3.4	3/31/2007
3.3	Certificate of Ownership and Merger Merging LABA Merger Sub, Inc. with and into Theravance, Inc., as filed with the Secretary of State of the State of Delaware, effective on January 7, 2016	8-K	3.1	1/8/2016
3.4	Amended and Restated Bylaws, amended and restated as of February 8, 2017	8-K	3.1	2/9/2017
4.1	Specimen certificate representing the common stock of the registrant	10-K	4.1	12/31/2006
4.2	Indenture, dated as of January 4, 2013 by and between Theravance, Inc. and the Bank of New York Mellon Trust Company, N.A., as trustee	8-K	4.1	1/25/2013
4.3	Form of 2.125% Convertible Subordinated Note Due 2023 (included in Exhibit 4.2)
4.4	Indenture (including form of Note) with respect to Innoviva’s 2.5% Convertible Senior Notes due 2025, dated as of August 7, 2017, between Innoviva and The Bank of New York Mellon Trust Company, N.A., as trustee	8-K	4.1	8/7/2017
4.5	Description of Registrant’s Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 1934	10-K	4.9	2/19/2020
4.6	Indenture (including form of Note) with respect to Innoviva’s 2.125% Convertible Senior Notes due 2028, dated as of March 7, 2022, between Innoviva and The Bank of New York Mellon Trust Company, N.A., as trustee	8-K	4.1	3/8/2022
10.1	Offer Letter between Innoviva, Inc. and Pavel Raifeld, dated April 29, 2022	8-K	10.1	5/2/2022
10.2	Amendment No. 1 to the Investor Rights Agreement, dated May 23, 2022, by and among Innoviva, Inc. and Entasas Therapeutics Holdings Inc	8-K	10.1	5/24/2022
10.3	Support Agreement, dated July 10, 2022, by and among Innoviva, Inc., Innoviva Acquisition Sub, Inc., Tang Capital Partners, LP and Kevin C. Tang Foundation	8-K	10.1	7/11/2022
10.4	Equity Purchase Agreement, dated July 13, 2022, by and among Innoviva, Inc., Innoviva TRC Holdings LLC and Royalty Pharma Investments 2019 ICAV.	8-K	10.1	7/13/2022
10.5	Third Amendment to Collaboration Agreement, dated July 13, 2022, by and among Innoviva, Inc., Glaxo Group Limited, and Theravance Respiratory Company, LLC.	8-K	10.2	7/13/2022
31.1	Certification of Principal Executive Officer pursuant to Rules 13a‑14 pursuant to the Securities Exchange Act of 1934
31.2	Certification of Principal Financial Officer pursuant to Rules 13a‑14 pursuant to the Securities Exchange Act of 1934
32	Certifications Pursuant to 18 U.S.C. Section 1350
101.INS	Inline XBRL Instance Document – the instance document does not appear in the Interactive Data File because XBRL tags are embedded within the Inline XBRL document.
101.SCH	Inline XBRL Taxonomy Extension Schema Document

40

101.CAL	Inline XBRL Taxonomy Extension Calculation Linkbase Document
101.DEF	Inline XBRL Taxonomy Extension Definition Linkbase Document
101.LAB	Inline XBRL Taxonomy Extension Label Linkbase Document
101.PRE	Inline XBRL Taxonomy Extension Presentation Linkbase Document
104	Cover Page Interactive Data File (embedded within the Inline XBRL document)

41

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

	Innoviva, Inc.
Date: July 27, 2022	/s/ Pavel Raifeld
	Pavel Raifeld
	Chief Executive Officer
	(Principal Executive Officer)
Date: July 27, 2022	/s/ Marianne Zhen
	Marianne Zhen
	Chief Accounting Officer
	(Principal Financial Officer)

42

EX-31.1

Exhibit 31.1

Certification of Principal Executive Officer

Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

I, Pavel Raifeld, certify that:

1. I have reviewed this quarterly report on Form 10-Q of Innoviva, Inc.;

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4. The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15(d)-15(f)) for the registrant and have:

a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

c) Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5. The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Date:	July 27, 2022	/s/ Pavel Raifeld
		Pavel Raifeld
		Chief Executive Officer
		(Principal Executive Officer)

EX-31.2

Exhibit 31.2

Certification of Principal Financial Officer

Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

I, Marianne Zhen, certify that:

1. I have reviewed this quarterly report on Form 10-Q of Innoviva, Inc.;

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4. The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15(d)-15(f)) for the registrant and have:

a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

c) Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5. The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Date:	July 27, 2022	/s/ Marianne Zhen
		Marianne Zhen
		Chief Accounting Officer
		(Principal Financial Officer)

EX-32

Exhibit 32

CERTIFICATION OF PRINCIPAL EXECUTIVE OFFICER

PURSUANT TO

18 U.S.C. SECTION 1350,

AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

I, Pavel Raifeld, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that the Quarterly Report of Innoviva, Inc. on Form 10-Q for the period ended June 30, 2022 fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended and that information contained in such Quarterly Report on Form 10-Q fairly presents in all material respects the financial condition of Innoviva, Inc. at the end of the periods covered by such Quarterly Report on Form 10-Q and results of operations of Innoviva, Inc. for the periods covered by such Quarterly Report on Form 10-Q.

Date:	July 27, 2022	By:	/s/ Pavel Raifeld
			Pavel Raifeld
			Chief Executive Officer
			(Principal Executive Officer)

CERTIFICATION OF PRINCIPAL FINANCIAL OFFICER

PURSUANT TO

18 U.S.C. SECTION 1350,

AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

I, Marianne Zhen, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that the Quarterly Report of Innoviva, Inc. on Form 10-Q for the period ended June 30, 2022 fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended and that information contained in such Quarterly Report on Form 10-Q fairly presents in all material respects the financial condition of Innoviva, Inc. at the end of the periods covered by such Quarterly Report on Form 10-Q and results of operations of Innoviva, Inc. for the periods covered by such Quarterly Report on Form 10-Q.

Date:	July 27, 2022	By:	/s/ Marianne Zhen
			Marianne Zhen
			Chief Accounting Officer
			(Principal Financial Officer)

XML

Document and Entity Information - shares	6 Months Ended
	Jun. 30, 2022	Jul. 15, 2022
Cover [Abstract]
Entity Registrant Name	INNOVIVA, INC.
Document Type	10-Q
Document Quarterly Report	true
Document Period End Date	Jun. 30, 2022
Document Transition Report	false
Entity File Number	000-30319
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	94-3265960
Entity Address, Address Line One	1350 Old Bayshore Highway Suite 400
Entity Address, City or Town	Burlingame
Entity Address, State or Province	CA
Entity Address, Postal Zip Code	94010
City Area Code	650
Local Phone Number	238-9600
Title of 12(b) Security	Common Stock, par value $0.01 per share
Trading Symbol	INVA
Security Exchange Name	NASDAQ
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Large Accelerated Filer
Entity Small Business	false
Entity Emerging Growth Company	false
Entity Shell Company	false
Entity Common Stock, Shares Outstanding		69,705,967
Entity Central Index Key	0001080014
Current Fiscal Year End Date	--12-31
Document Fiscal Year Focus	2022
Document Fiscal Period Focus	Q2
Amendment Flag	false

XML

CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Current assets:
Cash and cash equivalents	$ 283,580	$ 201,525
Related party receivables from collaborative arrangements	111,676	110,711
Prepaid expenses	3,953	1,367
Other current assets	1,119	70
Total current assets	400,328	313,673
Property and equipment, net	176	12
Equity and long-term investments	494,097	483,845
Capitalized fees paid to a related party, net	104,518	111,430
Right-of-use assets	3,545	97
Goodwill	5,544	0
Intangible assets	105,000	0
Deferred tax assets, net	23,274	17,327
Other assets	1,157	11
Total assets	1,137,639	926,395
Current liabilities:
Accounts payable	4,323	27
Accrued personnel-related expenses	3,871	619
Accrued interest payable	4,498	4,152
Convertible subordinated notes due 2023, net of issuance costs	96,072	0
Other accrued liabilities	17,144	1,009
Total current liabilities	125,908	5,807
Long-term debt, net of discount and issuance costs	443,178	394,653
Lease liabilities, long-term	3,091	0
Commitments and contingencies (Note 10)
Stockholders' equity:
Preferred stock: $0.01 par value, 230 shares authorized, no shares issued and outstanding	0	0
Common stock: $0.01 par value, 200,000 shares authorized, 69,706 and 69,566 issued and outstanding as of June 30, 2022 and December 31, 2021 respectively	697	696
Treasury stock: at cost, 32,005 shares at June 30, 2022 and December 31, 2021, respectively	(393,829)	(393,829)
Additional paid-in capital	1,183,667	1,264,024
Accumulated deficit	(402,198)	(456,148)
Total Innoviva stockholders' equity	388,337	414,743
Noncontrolling interest	177,125	111,192
Total stockholders' equity	565,462	525,935
Total liabilities and stockholders' equity	$ 1,137,639	$ 926,395

XML

CONDENSED CONSOLIDATED BALANCE SHEETS (Parenthetical) - $ / shares	Jun. 30, 2022	Dec. 31, 2021
Statement of Financial Position [Abstract]
Preferred stock, par value (in dollars per share)	$ 0.01	$ 0.01
Preferred stock, shares authorized	230,000	230,000
Preferred stock, shares issued	0	0
Preferred stock, shares outstanding	0	0
Common stock, par value (in dollars per share)	$ 0.01	$ 0.01
Common stock, shares authorized	200,000,000	200,000,000
Common stock, shares issued	69,706,000	69,566,000
Common stock, shares outstanding	69,706,000	69,566,000
Treasury stock, shares	32,005,000	32,005,000

XML

CONDENSED CONSOLIDATED STATEMENTS OF INCOME - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Total revenue	$ 108,220	$ 100,806	$ 198,279	$ 186,324
Operating expenses:
Research and development	13,884	38	19,722	87
General and administrative	11,782	4,228	18,274	10,214
Total operating expenses	25,666	4,266	37,996	10,301
Income from operations	82,554	96,540	160,283	176,023
Interest and dividend income	724	20	1,046	50
Other expense, net	(528)	(951)	(778)	(1,384)
Interest expense	(3,655)	(4,745)	(6,665)	(9,439)
Loss on extinguishment of debt	0	0	(20,662)	0
Changes in fair values of equity and long-term investments, net	(58,600)	45,315	(68,011)	100,360
Income before income taxes	20,495	136,179	65,213	265,610
Income tax expense (benefit), net	(876)	25,333	5,984	45,069
Net income	21,371	110,846	59,229	220,541
Net income attributable to noncontrolling interest	20,432	21,898	42,517	37,470
Net income attributable to Innoviva stockholders	$ 939	$ 88,948	$ 16,712	$ 183,071
Basic net income per share attributable to Innoviva stockholders	$ 0.01	$ 1.01	$ 0.24	$ 1.93
Diluted net income per share attributable to Innoviva stockholders	$ 0.05	$ 0.90	$ 0.24	$ 1.73
Shares used to compute Innoviva basic and diluted net income per share:
Shares used to compute basic net income per share	69,643	88,423	69,594	94,858
Shares used to compute diluted net income per share	95,653	100,639	94,692	107,096

XML

CONDENSED CONSOLIDATED STATEMENTS OF INCOME (Parenthetical) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Royalty revenue from a related party | GSK
Amortization of capitalized fees paid to a related party	$ 3,456	$ 3,456	$ 6,912	$ 6,912

XML

CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Statement of Comprehensive Income [Abstract]
Net Income	$ 21,371	$ 110,846	$ 59,229	$ 220,541
Comprehensive income	21,371	110,846	59,229	220,541
Comprehensive income attributable to noncontrolling interest	20,432	21,898	42,517	37,470
Comprehensive income attributable to Innoviva stockholders	$ 939	$ 88,948	$ 16,712	$ 183,071

XML

CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) $ in Thousands	Total	Common stock	Additional Paid-In Capital	Accumulated Other Comprehensive Income (Loss)	Accumulated Deficit	Treasury Stock	Noncontrolling Interest	Cumulative Effect, Period of Adoption, Adjustment [Member]	Cumulative Effect, Period of Adoption, Adjustment [Member] Additional Paid-In Capital	Cumulative Effect, Period of Adoption, Adjustment [Member] Accumulated Deficit
Balance at Dec. 31, 2020	$ 607,837	$ 1,014	$ 1,260,900	$ 0	$ (722,002)	$ 0	$ 67,925
Balance (in shares) at Dec. 31, 2020		101,392,000
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Distributions to noncontrolling interest	(21,285)	$ 0	0	0	0	0	(21,285)
Equity activity of noncontrolling interest from a consolidated variable interest entity	8	0	0	0	0	0	8
Exercise of stock options, and issuance of common stock units and stock awards, net of repurchase of shares to satisfy tax withholding	(25)	$ 0	(25)	0	0	0	0
Exercise of stock options, and issuance of common stock units and stock awards, net of repurchase of shares to satisfy tax withholding (in shares)		16,000
Stock-based compensation	451	$ 0	451	0	0	0	0
Net income	109,695	0	0	0	94,123	0	15,572
Balance at Mar. 31, 2021	696,681	$ 1,014	1,261,326	0	(627,879)	0	62,220
Balance (in shares) at Mar. 31, 2021		101,408,000
Balance at Dec. 31, 2020	607,837	$ 1,014	1,260,900	0	(722,002)	0	67,925
Balance (in shares) at Dec. 31, 2020		101,392,000
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net income	220,541
Balance at Jun. 30, 2021	393,745	$ 695	1,261,845	0	(538,931)	$ (393,829)	63,965
Balance (in shares) at Jun. 30, 2021		69,495,000				32,005,000
Balance at Mar. 31, 2021	696,681	$ 1,014	1,261,326	0	(627,879)	$ 0	62,220
Balance (in shares) at Mar. 31, 2021		101,408,000
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Distributions to noncontrolling interest	(20,161)	$ 0	0	0	0	0	(20,161)
Equity activity of noncontrolling interest from a consolidated variable interest entity	8	0	0	0	0	0	8
Exercise of stock options, and issuance of common stock units and stock awards, net of repurchase of shares to satisfy tax withholding	50	$ 1	49	0	0	0	0
Exercise of stock options, and issuance of common stock units and stock awards, net of repurchase of shares to satisfy tax withholding (in shares)		92,000
Repurchase of common stock	(394,149)	$ (320)	0	0	0	$ (393,829)	0
Repurchase of common stock (in shares)		32,005,000				(32,005,000)
Stock-based compensation	470	$ 0	470	0	0	$ 0	0
Net income	110,846	0	0	0	88,948	0	21,898
Balance at Jun. 30, 2021	393,745	$ 695	1,261,845	0	(538,931)	$ (393,829)	63,965
Balance (in shares) at Jun. 30, 2021		69,495,000				32,005,000
Balance at Dec. 31, 2021	$ 525,935	$ 696	1,264,024	0	(456,148)	$ (393,829)	111,192	$ (28,123)	$ (65,361)	$ 37,238
Balance (in shares) at Dec. 31, 2021	69,566,000	69,566,000				32,005,000
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Accounting Standards Update [Extensible Enumeration]								Accounting Standards Update 2020-06 [Member]	Accounting Standards Update 2020-06 [Member]	Accounting Standards Update 2020-06 [Member]
Distributions to noncontrolling interest	$ (6,507)	$ 0	0	0	0	$ 0	(6,507)
Fair value of noncontrolling interest in a consolidated variable interest entity	38,471	0	0	0	0	0	38,471
Exercise of stock options, and issuance of common stock units and stock awards, net of repurchase of shares to satisfy tax withholding	214	$ 0	214	0	0	0	0
Exercise of stock options, and issuance of common stock units and stock awards, net of repurchase of shares to satisfy tax withholding (in shares)		28,000
Stock-based compensation	954	$ 0	620	0	0	0	334
Capped call options associated with convertible senior notes due 2028	(16,585)	0	(16,585)	0	0	0	0
Net income	37,858	0	0	0	15,773	0	22,085
Balance at Mar. 31, 2022	552,217	$ 696	1,182,912	0	(403,137)	$ (393,829)	165,575
Balance (in shares) at Mar. 31, 2022		69,594,000				32,005,000
Balance at Dec. 31, 2021	$ 525,935	$ 696	1,264,024	0	(456,148)	$ (393,829)	111,192	$ (28,123)	$ (65,361)	$ 37,238
Balance (in shares) at Dec. 31, 2021	69,566,000	69,566,000				32,005,000
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net income	$ 59,229
Balance at Jun. 30, 2022	$ 565,462	$ 697	1,183,667	0	(402,198)	$ (393,829)	177,125
Balance (in shares) at Jun. 30, 2022	69,706,000	69,706,000				32,005,000
Balance at Mar. 31, 2022	$ 552,217	$ 696	1,182,912	0	(403,137)	$ (393,829)	165,575
Balance (in shares) at Mar. 31, 2022		69,594,000				32,005,000
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Distributions to noncontrolling interest	(9,545)	$ 0	0	0	0	$ 0	(9,545)
Equity activity of noncontrolling interest from a consolidated variable interest entity	(2)	0	0	0	0	0	(2)
Exercise of stock options, and issuance of common stock units and stock awards, net of repurchase of shares to satisfy tax withholding	68	$ 1	67	0	0	0	0
Exercise of stock options, and issuance of common stock units and stock awards, net of repurchase of shares to satisfy tax withholding (in shares)		112,000
Conversion of convertible subordinated notes due 2023	3	$ 0	3	0	0	0	0
Stock-based compensation	1,350	0	685	0	0	0	665
Net income	21,371	0	0	0	939	0	20,432
Balance at Jun. 30, 2022	$ 565,462	$ 697	$ 1,183,667	$ 0	$ (402,198)	$ (393,829)	$ 177,125
Balance (in shares) at Jun. 30, 2022	69,706,000	69,706,000				32,005,000

XML

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Cash flows from operating activities
Net income	$ 59,229	$ 220,541
Adjustments to reconcile net income to net cash provided by operating activities:
Deferred income tax	5,984	45,069
Depreciation and amortization	7,092	6,918
Stock-based compensation	2,304	921
Amortization of debt discount and issuance costs	931	4,472
Changes in fair values of equity and long-term investments, net	68,011	(99,046)
Loss on extinguishment of debt	20,662	0
Other	857	16
Changes in operating assets and liabilities:
Receivables from collaborative arrangements	(965)	(10,331)
Prepaid expenses	2,968	578
Other assets, current	910	328
Other assets, non-current	(844)	0
Accounts payable	2,713	(36)
Accrued personnel-related expenses and other accrued liabilities	6,939	(709)
Accrued interest payable	346	0
Net cash provided by operating activities	177,137	168,721
Cash flows from investing activities
Purchases of equity and long term investments	(58,726)	(46,373)
Purchases of equity investments managed by ISP Fund LP	(38,026)	(142,636)
Sale of equity investments managed by ISP Fund LP	24,281	18,545
Purchase and sales of other investments managed by ISP Fund LP, net	(96,255)	234,091
Purchases of property and equipment	(22)	0
Cash acquired through the consolidation of Entasis Therapeutics Holdings, Inc.	23,070	0
Net cash provided by (used in) investing activities	(145,678)	63,627
Cash flows from financing activities
Distributions to noncontrolling interest	(16,054)	(41,446)
Repurchase of common stock	0	(394,149)
Repurchase of shares to satisfy tax withholding	(59)	(35)
Proceeds from issuances of common stock, net	341	60
Payment for repurchase of convertible subordinated notes due 2023	(165,131)	0
Purchases of capped call options associated with convertible senior notes due 2028	(21,037)	0
Proceeds from issuance of convertible senior notes due 2028, net of issuance costs	252,536	0
Net cash provided by (used in) financing activities	50,596	(435,570)
Net increase (decrease) in cash and cash equivalents	82,055	(203,222)
Cash and cash equivalents at beginning of period	201,525	246,487
Cash and cash equivalents at end of period	283,580	43,265
Supplemental disclosure of cash flow information
Cash paid for interest	5,411	4,967
Supplemental disclosure of non-cash investing and financing activities
Right-of-use asset obtained through the consolidation of Entasis Therapeutics Holdings, Inc.	3,289	0
ASU 2020-06
Supplemental disclosure of non-cash investing and financing activities
Adoption of ASU 2020-06	$ 28,123	$ 0

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Description of Operations and Summary of Significant Accounting Policies

6 Months Ended

Jun. 30, 2022

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Description of Operations and Summary of Significant Accounting Policies

1. Description of Operations and Summary of Significant Accounting Policies

Description of Operations

Innoviva Inc. (referred to as “Innoviva”, the “Company”, or “we” and other similar pronouns) is a company with a portfolio of royalties and other healthcare assets. Our royalty portfolio contains respiratory assets partnered with Glaxo Group Limited (“GSK”), including RELVAR®/BREO® ELLIPTA® (fluticasone furoate/ vilanterol, “FF/VI”), ANORO® ELLIPTA® (umeclidinium bromide/ vilanterol, “UMEC/VI”) and TRELEGY® ELLIPTA® (the combination FF/UMEC/VI). Under the Long-Acting Beta2 Agonist (“LABA”) Collaboration Agreement, Innoviva is entitled to receive royalties from GSK on sales of RELVAR®/BREO® ELLIPTA® as follows: 15% on the first $3.0 billion of annual global net sales and 5% for all annual global net sales above $3.0 billion; and royalties from the sales of ANORO® ELLIPTA®, which tier upward at a range from 6.5% to 10%. Innoviva is also entitled to 15% of royalty payments made by GSK under its agreements originally entered into with us, and since assigned to Theravance Respiratory Company, LLC (“TRC”), including TRELEGY® ELLIPTA® and any other product or combination of products that may be discovered or developed in the future under the LABA Collaboration Agreement and the Strategic Alliance Agreement with GSK (referred to herein as the “GSK Agreements”), which have been assigned to TRC other than RELVAR®/BREO® ELLIPTA® and ANORO® ELLIPTA®.

Basis of Presentation

The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America (“US GAAP”) for interim financial information. Accordingly, they do not include all of the information and notes required by US GAAP for complete financial statements. In our opinion, the unaudited condensed consolidated financial statements have been prepared on the same basis as audited consolidated financial statements and include all adjustments, consisting of only normal recurring adjustments, necessary for the fair presentation of our financial position, results of operations, comprehensive income and cash flows. The interim results are not necessarily indicative of the results of operations to be expected for the year ending December 31, 2022 or any other period.

The accompanying unaudited condensed consolidated financial statements include the accounts of Innoviva, our wholly-owned subsidiaries and certain variable interest entities for which we are the primary beneficiary. All intercompany balances and transactions have been eliminated in consolidation. For consolidated entities where we own or are exposed to less than 100% of the economics, we record net income attributable to noncontrolling interest in our unaudited condensed consolidated statements of income equal to the percentage of the economic or ownership interest retained in such entities by the respective noncontrolling parties. The accompanying unaudited condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and notes thereto included in our Annual Report on Form 10-K for the year ended December 31, 2021 filed with the Securities and Exchange Commission (“SEC”) on February 28, 2022, and as amended on March 17, 2022 (“2021 Form 10-K”).

Prior Period Immaterial Correction

Subsequent to the issuance of the unaudited condensed consolidated financial statements for the three and six months ended June 30, 2021, the Company identified that (i) purchases of equity investments managed by ISP Fund LP for $142.6 million, (ii) sales of equity investments managed by ISP Fund LP for $18.5 million, and (iii) purchase and sales of other investments managed by ISP Fund LP, net for $234.1 million were incorrectly netted in the unaudited condensed consolidated statement of cash flows within the distribution of equity and long-term investments line item. The Company has corrected the presentation in the accompanying unaudited condensed consolidated statement of cash flows for the six months ended June 30, 2021 from amounts previously reported to present such line items separately. The correction did not impact total cash flows from investing activities or the unaudited condensed consolidated balance sheet, statement of income, or statement of comprehensive income. Management assessed the correction on a quantitative and qualitative basis and determined that it is immaterial to the prior period unaudited condensed consolidated financial statements.

Use of Management’s Estimates

The preparation of unaudited condensed consolidated financial statements in conformity with US GAAP requires management to make estimates and assumptions that affect the amounts reported in the unaudited condensed consolidated financial statements and accompanying notes. Actual results could differ materially from those estimates. Management evaluates its significant accounting policies and estimates on an ongoing basis. We base our estimates on historical experience and other relevant assumptions that we believe to be reasonable under the circumstances. These estimates also form the basis for making judgments about the carrying values of assets and liabilities when these values are not readily apparent from other sources.

Certain Risks and Concentrations

Our financial instruments that are exposed to concentrations of credit risk consist primarily of cash and cash equivalents, marketable securities, equity and long-term investments. Although we deposit our cash with multiple financial institutions, our deposits, at times, may exceed federally insured limits.

Segment Reporting

We operate in a single segment, which is to provide capital return to stockholders by maximizing the potential value of our respiratory assets partnered with GSK. Revenues are generated from our collaborative arrangements and royalty payments from GSK, located in Great Britain. Our facilities are located within the United States.

Variable Interest Entities

We evaluate our ownership, contractual and other interest in entities to determine if they are a variable interest entity (“VIE”). We evaluate whether we have a variable interest in those entities and the nature and extent of those interests. Based on our evaluation, if we determine we are the primary beneficiary of a VIE, we consolidate the entity in our financial statements.

Equity and Long-Term Investments

We invest from time to time in equity and debt securities of private or public companies. If we determine that we have control over these companies under either voting or VIE models, we include them in our unaudited condensed consolidated financial statements. If we determine that we do not have control over these companies under either voting or VIE models, we then determine if we have an ability to exercise significant influence via voting interests, board representation or other business relationships.

We may account for the investments where we exercise significant influence using either an equity method of accounting or at fair value by electing the fair value option under Accounting Standards Codification (“ASC”) Topic 825, Financial Instruments. If the fair value option is applied to an investment that would otherwise be accounted for under the equity method, we apply it to all our financial interests in the same entity (equity and debt, including guarantees) that are eligible items. All gains and losses from fair value changes, unrealized and realized, are presented as changes in fair values of equity and long-term investments, net on the unaudited condensed consolidated statements of income.

If we conclude that we do not have an ability to exercise significant influence over an investee, we may elect to account for the security without a readily determinable fair value using the measurement alternative under ASC Topic 321, Investments - Equity Securities. This measurement alternative allows us to measure the equity investment at its cost minus impairment, if any, plus or minus changes resulting from observable price changes in orderly transactions for the identical or a similar investment of the same issuer.

We also invest in ISP Fund LP, which investments consist of money market funds and equity securities in the healthcare, pharmaceutical and biotechnology industries. Pursuant to the Partnership Agreement entered in December 2020, we became a limited partner of this partnership, and our contributions are subject to a 36-month lock-up period which restriction prevents us from having control and access to the contributions and related investments. These investments are classified as long-term investments on the unaudited condensed consolidated balance sheets.

Revenue Recognition

Revenue is recognized when our customer obtains control of promised goods or services, in an amount that reflects the consideration which we expect to receive in exchange for those goods or services. Revenue is recognized through a five-step process: (i) identify the contract with the customer; (ii) identify the performance obligations in the contract; (iii) determine the transaction price for the contract; (iv) allocate the transaction price to the performance obligations in the contract; and (v) recognize revenue as a performance obligation is satisfied.

We recognize the royalty revenue on net sales of products with respect to which we have contractual royalty rights in the period in which the royalties are earned. The net sales reports provided by our partner are based on its methodology and assumptions to estimate rebates and returns, which it monitors and adjusts regularly in light of contractual and legal obligations, historical trends, past experience and projected market conditions. Our partner may make significant adjustments to its sales based on actual results recorded, which could cause our royalty revenue to fluctuate. We have the ability to conduct periodic royalty audits to evaluate the information provided by our partner. Royalties are recognized net of amortization of capitalized fees associated with any approval and launch milestone payments made to GSK.

Research and Development Costs

Research and development costs are expensed in the period that services are rendered or goods are received. Research and development costs consist of salaries and benefits, laboratory supplies and facility costs, as well as fees paid to third parties that conduct certain research and development activities on behalf of the Company’s consolidated variable interest entity, net of certain external research and development costs reimbursed under the collaboration arrangements of the Company’s consolidated variable interest entity. Non-refundable pre-payments for goods or services that will be used or rendered for future research and development activities are deferred. The Company’s consolidated variable interest entity also utilizes significant judgment and estimates to record accruals for estimated ongoing research costs based on the progress of the studies.

Goodwill and Intangible Assets

Goodwill is recognized as the excess of the purchase price of an acquired entity over the fair value of amount assigned to assets acquired and liabilities assumed in a business combination. Goodwill and intangible assets with indefinite lives is subject to impairment testing at least annually and will be tested for impairment between annual tests if a triggering event occurs, such as changes due to circumstances that would indicate an impairment of the carrying value. Significant judgments are involved in determining if an indicator of impairment has occurred. Intangible assets with definite lives are amortized on a straight-line basis over the remaining useful life of the intangible asset.

Operating Leases

We account for our leases in accordance with Financial Accounting Standards Board (“FASB”) Accounting Standards Codification (“ASC”) 842, “Leases” (“ASC 842”). Right-of-use assets represent our right to use an underlying asset over the lease term and include any lease payments made prior to the lease commencement date and are reduced by lease incentives. Lease liabilities represent the present value of the total lease payments over the lease term, calculated using an estimated incremental borrowing rate. Lease expense is recognized on a straight-line basis over the expected lease term.

Accounting Pronouncement Adopted by the Company

In August 2020, the FASB issued ASU 2020-06, Debt-Debt with Conversion and Other Options (Subtopic 470-20) and Derivatives and Hedging-Contracts in Entity’s Own Equity (Subtopic 815-40): Accounting for Convertible Instruments and Contracts in an Entity’s Own Equity, which is intended to simplify the accounting for convertible instruments by removing certain separation models in Subtopic 470-20 for convertible instruments. Consequently, a convertible debt instrument will be accounted for as a single liability measured at its amortized cost, as long as no other features require bifurcation and recognition as derivatives. The new standard also requires the if-converted method to be used to calculate diluted earnings per share (“EPS”) for convertible instruments.

Effective January 1, 2022, we adopted the new standard using the modified retrospective approach and assessed the effect of this adoption on the accounting for our outstanding convertible notes. The effect of the adoption on our 2025 Notes (as defined below) resulted in a decrease to the opening balance of accumulated deficit of $37.2 million, a reduction to additional paid-in capital of $65.4 million, an increase to the balance of the notes by an aggregate amount of $35.6 million, and an increase to deferred tax assets of $7.4 million. The dilutive EPS of our 2025 Notes will be computed under the if-converted method going forward. There was no financial impact from the implementation of the standard for our 2023 Notes (as defined below). Refer to Note 8, “Debt” for more information.

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Net Income Per Share

6 Months Ended

Jun. 30, 2022

Earnings Per Share [Abstract]

Net Income Per Share

2. Net Income Per Share

Basic net income per share attributable to Innoviva stockholders is computed by dividing net income attributable to Innoviva stockholders by the weighted-average number of shares of common stock outstanding. Diluted net income per share attributable to Innoviva stockholders is computed by dividing net income attributable to Innoviva stockholders by the weighted-average number of shares of common stock and dilutive potential common stock equivalents then outstanding. Dilutive potential common stock equivalents include the assumed exercise, vesting and issuance of employee stock awards using the treasury stock method, as well as common stock issuable upon assumed conversion of our convertible subordinated notes due 2023 (the “2023 Notes”), our convertible senior notes due 2025 (the “2025 Notes”) and our convertible senior notes due 2028 (the “2028 Notes”) using the if-converted method.

Our convertible senior notes due 2025 (the “2025 Notes”) are convertible, based on the applicable conversion rate, into cash, shares of our common stock or a combination thereof, at our election. Our current intent is to settle the principal amount of the 2025 Notes in cash upon conversion. The impact of the assumed conversion premium to diluted net income per share was historically computed using the treasury stock method. As the average market price per share of our common stock as reported on The Nasdaq Global Select Market was lower than the initial conversion price of $17.26 per share, there was no dilutive effect of the assumed conversion premium for the three and six months ended June 30, 2021. The dilutive EPS of the notes was approximately $0.01 and $0.03 per share, respectively, using the if-converted method for the three and six months ended June 30, 2022 as a result of the adoption of ASU 2020-06.

The following table shows the computation of basic and diluted net income per share for the three and six months ended June 30, 2022 and 2021:

	Three Months Ended June 30,				Six Months Ended June 30,
(In thousands except per share data)	2022		2021		2022		2021
Numerator:
Net income attributable to Innoviva stockholders, basic	$	939	$	88,948	$	16,712	$	183,071
Add: interest expense on 2023 Notes		570		1,163		1,591		2,367
Add: interest expense on 2025 Notes		1,375		—		2,539		—
Add: interest expense on 2028 Notes		1,709		—		2,093		—
Net income attributable to Innoviva stockholders, diluted	$	4,593	$	90,111	$	22,935	$	185,438
Denominator:
Weighted-average shares used to compute basic net income    per share attributable to Innoviva stockholders		69,643		88,423		69,594		94,858
Dilutive effect of 2023 Notes		4,866		12,189		7,511		12,189
Dilutive effect of 2025 Notes		11,150		—		11,150		—
Dilutive effect of 2028 Notes		9,955		—		6,360		—
Dilutive effect of options and awards granted under equity    incentive plan and employee stock purchase plan		39		27		77		49
Weighted-average shares used to compute diluted net income    per share attributable to Innoviva stockholders		95,653		100,639		94,692		107,096
Net income per share attributable to Innoviva stockholders
Basic	$	0.01	$	1.01	$	0.24	$	1.93
Diluted	$	0.05	$	0.90	$	0.24	$	1.73

Anti-Dilutive Securities

The following common stock equivalents were not included in the computation of diluted net income per share because their effect was anti-dilutive for the periods presented:

	Three Months Ended June 30,				Six Months Ended June 30,
(In thousands)	2022		2021		2022		2021
Outstanding options and awards granted under equity incentive    plan and employee stock purchase plan		642		1,093		514		1,126

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Revenue Recognition and Collaborative Arrangements

6 Months Ended

Jun. 30, 2022

Revenue from Contract with Customer [Abstract]

Revenue Recognition and Collaborative Arrangements

3. Revenue Recognition and Collaborative Arrangements

We recognize royalty revenue on net sales of products with respect to which we have contractual royalty rights in the period in which the royalties are earned. Royalties, which may include adjustments of estimates of net sales in prior periods, are recognized net of amortization of capitalized fees associated with any approval and launch milestone payments made to GSK.

Net Revenue from Collaborative Arrangements

Net revenue recognized under our GSK Agreements was as follows:

	Three Months Ended June 30,						Six Months Ended June 30,
(In thousands)	2022			2021			2022			2021
Royalties from a related party    - RELVAR/BREO	$	59,326		$	65,916		$	115,090		$	122,306
Royalties from a related party    - ANORO		9,630			11,960			18,072			22,460
Royalties from a related party    - TRELEGY		42,720			26,386			72,029			48,470
Total royalties from a related party		111,676			104,262			205,191			193,236
Less: amortization of capitalized fees    paid to a related party		(3,456	)		(3,456	)		(6,912	)		(6,912	)
Royalty revenue from GSK	$	108,220		$	100,806		$	198,279		$	186,324

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Consolidated Entities

6 Months Ended

Jun. 30, 2022

Consolidated Entities

Consolidated Entities

4. Consolidated Entities

We consolidate the financial results of Theravance Respiratory Company, LLC (“TRC”) and Entasis Therapeutics Holdings, Inc. (“Entasis”), which we have determined to be VIEs. As we have the power to direct the economically significant activities of these entities and the obligation to absorb losses of, or the right to receive benefits from them, we are the primary beneficiary of the entities. We also consolidate the financial results of ISP Fund LP (the “Partnership”), which is our partnership with Sarissa Capital Management LP (“Sarissa Capital”), as we have determined that the Partnership is a VIE and we are its primary beneficiary.

Theravance Respiratory Company, LLC

We held 15% of the economic interest of TRC as of June 30, 2022 and December 31, 2021. The primary source of revenue for TRC is the royalties generated from the net sales of TRELEGY® ELLIPTA® by GSK. As of June 30, 2022, TRC held equity and long-term investments in InCarda Therapeutics, Inc. (“InCarda”), ImaginAb, Inc. (“ImaginAb”), Gate Neurosciences, Inc. (“Gate”) and Nanolive SA (“Nanolive”). Refer to Note 5, “Financial Instruments and Fair Value Measurements,” for more information.

The summarized financial information for TRC is presented as follows:

Balance sheets

	June 30,		December 31,
(In thousands)	2022		2021
Assets
Cash and cash equivalents	$	89,806	$	50,713
Receivables from collaborative arrangements		42,720		42,492
Prepaid expenses and other current assets		85		71
Equity and long-term investments		42,536		37,695
Total assets	$	175,147	$	130,971
Liabilities and LLC Members’ Equity
Current liabilities	$	493	$	252
LLC members’ equity		174,654		130,719
Total liabilities and LLC members’ equity	$	175,147	$	130,971

Income statements

	Three Months Ended June 30,						Six Months Ended June 30,
(In thousands)	2022			2021			2022			2021
Royalty revenue from a related party	$	42,720		$	26,386		$	72,029		$	48,470
Operating expenses		139			336			337			3,617
Income from operations		42,581			26,050			71,692			44,853
Other income, net		10			—			10			—
Income tax expense, net		—			—			1			—
Changes in fair values of equity and long-term    investments		(9,313	)		(254	)		(8,884	)		(737	)
Net income	$	33,278		$	25,796		$	62,819		$	44,116

Entasis Therapeutics Holdings, Inc.

We started investing in Entasis in 2020 as part of our capital allocation strategy of deploying cash generated from royalty income and investing in different life sciences companies. Entasis is a clinical-stage biotechnology company focused on the discovery and development of novel antibacterial products. During the second quarter of 2020, we purchased 14,000,000 shares of common stock as well as warrants to purchase 14,000,000 additional shares of common stock of Entasis for approximately $35.0 million in cash. During the third quarter of 2020, we purchased 4,672,897 shares of Entasis common stock as well as warrants to purchase 4,672,897 additional shares of its common stock for approximately $12.5 million in cash. Effective in June 2020, after certain conditions were met with respect to the sales of Entasis equity shares, Innoviva has a right to designate two members to Entasis’ board. During the second quarter of 2021, Innoviva’s wholly owned subsidiary, Innoviva Strategic Opportunities, LLC (“ISO”) entered into a securities purchase agreement with Entasis to acquire 10,000,000 shares of Entasis common stock and warrants to purchase 10,000,000 additional shares of Entasis common stock for approximately $20.0 million.

The fair value of Entasis’ common stock is measured based on its closing market price at each balance sheet date. The warrants have an exercise price of $2.50 per share and $2.675 per share for those warrants acquired in the second and third quarter of 2020, respectively. The warrants acquired in the second quarter of 2021 have an exercise price of $2.00 per share. All of the warrants are exercisable immediately within five years from the issuance date of the warrants and include a cashless exercise option. We use the Black-Scholes-Merton pricing model to estimate the fair value of these warrants.

On February 17, 2022, ISO entered into a securities purchase agreement with Entasis pursuant to which ISO purchased a convertible promissory note for a total purchase price of $15.0 million. The note bears an annual interest rate of 0.59% and will mature and become payable on August 18, 2022 unless it is converted at a conversion price of $1.48 before the maturity date. The financing is expected to support Entasis’ product development and operations into August 2022. With this financing, we determined that we have both (i) the power to direct the economically significant activities of Entasis and (ii) the obligation to absorb the losses, or the right to receive the benefits, that could potentially be significant to Entasis and therefore, we are the primary beneficiary of Entasis. Accordingly, we consolidated Entasis’ financial position and results of operations effective on February 17, 2022. Our equity ownership interest remained at 59.9% as of February 17, 2022, and the fair values of our holdings of Entasis common stock and warrants were remeasured and estimated at $64.5 million and $31.4 million, respectively. The remeasurement resulted in a $7.7 million loss which was included in changes in fair values of equity and long-term investments, net on the unaudited condensed consolidated statement of income for the six months ended June 30, 2022.

The fair values assigned to assets acquired and liabilities assumed are based on management’s best estimates and assumptions as of the reporting date. The Company has completed a preliminary valuation and expects to finalize it as soon as practical, but no later than one year from the acquisition date. The purchase accounting for this transaction is not yet finalized.

The following table summarizes the preliminary allocation of the fair values assigned to the assets acquired and liabilities assumed as of the date of the consolidation:

(In thousands)	February 17, 2022
Cash and cash equivalents	$	23,070
Prepaid expenses		5,554
Other current assets		1,959
Property and equipment, net		185
Right-of-use assets		527
Goodwill		5,544
Intangible assets		105,000
Other assets		302
Total assets acquired	$	142,141
Accounts payable	$	1,583
Accrued personnel-related expenses		1,057
Other current liabilities		5,096
Total liabilities assumed	$	7,736
Total assets acquired, net	$	134,405

Entasis’ assets can only be used to settle its obligations. The following table provides the assets and liabilities of Entasis:

(In thousands)	June 30, 2022
Assets
Current assets:
Cash and cash equivalents	$	22,408
Prepaid expenses		3,177
Other current assets		1,035
Total current assets		26,620
Property and equipment, net		171
Right-of-use assets		3,503
Goodwill		5,544
Intangible assets		105,000
Other assets		1,147
Total assets	$	141,985
Liabilities
Current liabilities:
Accounts payable	$	4,025
Accrued personnel-related expenses		3,385
Other accrued liabilities		8,195
Total current liabilities		15,605
Lease liabilities, long-term		3,091
Total liabilities	$	18,696

As a result of the consolidation, we recognized a non-controlling interest of $38.5 million as of February 17, 2022. Our unaudited condensed consolidated net income for the three and six months ended June 30, 2022 included the net loss attributable to Innoviva stockholders since the consolidation date of $11.7 million and $16.3 million, respectively, for Entasis.

The following table sets forth the pro-forma consolidated results of operations for the three and six months ended June 30, 2022 and 2021 as if the consolidation of Entasis occurred on January 1, 2021. The unaudited supplemental pro forma net income is adjusted by (i) reducing $64.7 million positive change in fair value related to the equity investments in Entasis’ common stock and warrants for the three months ended June 30, 2021, and increasing $7.8 million and reducing $53.2 million for the six months ended June 30, 2022 and 2021 respectively, and (ii) an increase for acquisition-related costs of $0.1 million for the six months ended June 30, 2022 and a corresponding decrease related to such costs for the six months ended June 30, 2021, as if the expenses were incurred in 2021 instead of 2022. The pro forma results of operations are presented for informational purposes only and are not indicative of the results of operations that would have been achieved if the consolidation had taken place on the dates noted above, or of results that may occur in the future.

	Three Months Ended June 30,					Six Months Ended June 30,
(In thousands)	2022			2021		2022		2021
Revenue	$	108,220		$	100,806	$	198,279	$	186,324
Net income	$	17,221		$	34,140	$	55,248	$	144,490
Net income attributable to Innoviva stockholders	$	(3,306	)	$	17,063	$	15,727	$	116,130

On July 11, 2022, we announced the completion of our acquisition of Entasis by purchasing the remaining portion of noncontrolling interest. Refer to Note 12, “Subsequent Events,” for more information.

ISP Fund LP

In December 2020, Innoviva Strategic Partners LLC, our wholly owned subsidiary (“Strategic Partners”), contributed $300.0 million to ISP Fund LP (the “Partnership”) for investing in “long” positions in the healthcare, pharmaceutical and biotechnology sectors and became a limited partner. The general partner of the Partnership (“General Partner”) is an affiliate of Sarissa Capital.

The Partnership Agreement provides for Sarissa Capital to receive management fees from the Partnership, payable quarterly in advance, measured based on the Net Asset Value of Strategic Partners’ capital account in the Partnership. In addition, General Partner is entitled to an annual performance fee based on the Net Profits of the Partnership during the annual measurement period.

The Partnership Agreement includes a lock-up period of thirty-six months after which Strategic Partners is entitled to make withdrawals from the Partnership as of such lock-up expiration date and each anniversary thereafter, subject to certain limitations.

In May 2021, Strategic Partners received a distribution of $110.0 million from the Partnership to provide funding to Innoviva for a strategic repurchase of shares held by GSK. On March 30, 2022, Strategic Partners made an additional capital contribution of $110.0 million to the Partnership pursuant to the letter agreement entered into between Strategic Partners, the Partnership and Sarissa Capital Fund GP LP on May 20, 2021. The capital contribution is subject to a 36-month lock up period from the contribution date.

As of June 30, 2022, we held approximately 100% of the economic interest of the Partnership. As of June 30, 2022 and December 31, 2021, total assets of the Partnership were $306.9 million and $195.8 million, respectively, of which the majority was attributable to equity and long-term investments, and total liabilities were $6.4 million and $0.2 million, respectively. The partnership’s assets can only be used to settle its own obligations. During the three and six months ended June 30, 2022, we recorded $0.5 million and $0.7 million, respectively, of net investment-related expenses incurred by the Partnership, and $6.5 million and $4.4 million, respectively, of net negative changes in fair values of equity and long-term investments on the unaudited condensed consolidated statements of income. During the three and six months ended June 30, 2021, we recorded $0.9 million and $1.3 million, respectively, of net investment-related expenses incurred by the Partnership, and $25.2 million and $31.0 million, respectively, of net positive changes in fair values of equity and long-term investments on the unaudited condensed consolidated statements of income.

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Financial Instruments and Fair Value Measurements

6 Months Ended

Jun. 30, 2022

Fair Value Disclosures [Abstract]

Financial Instruments and Fair Value Measurements

5. Financial Instruments and Fair Value Measurements

Equity Investment in Armata

During the first quarter of 2020, Innoviva acquired 8,710,800 shares of common stock as well as warrants to purchase 8,710,800 additional shares of common stock of Armata Pharmaceuticals, Inc. (“Armata”) for approximately $25.0 million in cash. Armata is a clinical stage biotechnology company focused on precisely targeted bacteriophage therapeutics for antibiotic-resistant infections.

During the first quarter of 2021, ISO entered into a securities purchase agreement with Armata to acquire 6,153,847 shares of Armata common stock and warrants to purchase 6,153,847 additional shares of Armata common stock for approximately $20.0 million. Armata also entered into a voting agreement with the Company and ISO, pursuant to which the Company and ISO agreed not to vote or take any action by written consent with respect to any common shares held by the Company and ISO that represent, in the aggregate, more than 49.5% of the total number of shares of Armata’s common stock for voting on the matters related to election or removal of Armata’s board members. The voting agreement will expire the earlier of the second anniversary of the agreement effective date and approval by the FDA of any of Armata’s product candidates for marketing and commercial distribution. During the fourth quarter of 2021, ISO also purchased an additional 1,212,122 shares of Armata common stock for approximately $4.0 million.

On February 9, 2022, ISO entered into a securities purchase agreement with Armata to acquire 9,000,000 shares of Armata common stock and warrants to purchase 4,500,000 additional shares of common stock with an exercise price of $5.00 per share for $45.0 million. The investment closed in two tranches on February 9, 2022 and March 31, 2022. The investment is intended to aid Armata in advancing its clinical pipeline and strengthening its bacteriophage platform. On February 9, 2022, Armata also entered a second amended and restated voting agreement with the Company and ISO, pursuant to which the Company and ISO agreed not to vote or take any action by written consent with respect to any common shares held by the Company and ISO that represent, in the aggregate, more than 49.5% of the total number of shares of Armata’s common stock for voting on the matters related to election or removal of Armata’s board members or amend the bylaws of Armata to reduce the maximum number of directors or set the number of directors who may serve on the board of Armata. The voting agreement will expire the earlier of the second anniversary of the agreement effective date and approval by the FDA of any of Armata’s product candidates for marketing and commercial distribution. In addition, as of February 9, 2022, Armata entered into an amended and restated investor rights agreement with the Company and ISO, pursuant to which for as long as the Company and ISO hold at least 12.5% of the outstanding shares of Armata’s common stock on a fully-diluted, the Company and ISO shall have the right to designate two directors to Armata’s board of directors, and for so long as the Company and ISO hold at least 8%, but less than 12.5%, of the outstanding shares of Armata’s common stock on a fully-diluted basis, the Company and ISO shall have the right to designate one director to Armata’s board of directors, subject to certain conditions and qualifications set forth in the amended and restated investor rights agreement. As of June 30, 2022, three of the eight members of Armata’s board of directors are also members of the board of directors of Innoviva. As of June 30, 2022 and December 31, 2021, we owned approximately 69.4% and 59.3%, respectively, of Armata’s common stock.

The investments in Armata provide Innoviva and ISO the ability to have significant influence, but not control over Armata’s operations. Armata’s business and affairs are managed under the direction of its board of directors, which Innoviva and ISO do not control. Based on our evaluation, we determined that Armata is a VIE, but Innoviva and ISO are not the primary beneficiary of the VIE. We continue to elect the fair value option to account for both Armata’s common stock and warrants. The fair value of Armata’s common stock is measured based on its closing market price. The warrants purchased in 2020, 2021 and 2022 have an exercise price of $2.87, $3.25 and $5.00 per share, respectively. All warrants are exercisable immediately within five years from the issuance date of the warrants and include a cashless exercise option. We use the Black-Scholes-Merton pricing model to estimate the fair value of these warrants with the following input assumptions: Armata’s closing market price on the valuation date, the risk-free interest rate computed based on the U.S. Treasury yield, the remaining contractual term as the expected term, and the expected stock price volatility calculated based on the historical volatility of the common stock of Armata and its peer companies.

As of June 30, 2022, the fair values of our holdings of Armata common stock and warrants were estimated at $97.6 million and $47.1 million, respectively. As of December 31, 2021, the fair values of our holdings of Armata common stock and warrants were estimated at $88.1 million and $58.6 million, respectively. The total fair value of both financial instruments in the amount of $144.7 million and $146.7 million was recorded as equity and long-term investments on the unaudited condensed consolidated balance sheets as of June 30, 2022 and December 31, 2021, respectively. During the three and six months ended June 30, 2022, we recorded $42.8 million and $47.0 million unrealized loss, respectively, as changes in fair values of equity and long-term investments, net on the unaudited condensed consolidated statements of income. During the three and six months ended June 30, 2021, we recorded $24.3 million unrealized loss and $36.9 million unrealized gains, respectively, as changes in fair values of equity and long-term investments, net on the unaudited condensed consolidated statements of income.

The summarized financial information, including the portion we do not own, is presented for Armata on a one quarter lag regardless of the date of our investments as follows:

Income Statement Information

	Three Months Ended March 31,						Six Months Ended March 31,
(In thousands)	2022			2021			2022			2021
Revenue	$	1,236		$	1,066		$	2,225		$	1,570
Loss from operations	$	(8,775	)	$	(5,435	)	$	(14,823	)	$	(11,888	)
Net loss	$	(8,774	)	$	(5,495	)	$	(14,821	)	$	(12,119	)

Equity Investment in InCarda

During the third quarter of 2020, TRC purchased 20,469,432 shares of Series C preferred stock and a warrant to purchase 5,117,358 additional shares of Series C preferred stock of InCarda Therapeutics, Inc. (“InCarda”) (the “InCarda 2020 Warrant”) for $15.8 million, which includes $0.8 million of transaction costs. InCarda is a privately held biopharmaceutical company focused on developing inhaled therapies for cardiovascular diseases. The investment is intended to fund the ongoing clinical development of InRhythmTM (flecainide for inhalation), the company’s lead program, for the treatment of a recent-onset episode of paroxysmal atrial fibrillation. TRC has the right to designate one member to InCarda’s board. As of June 30, 2022, one of InCarda’s eight board members was designated by TRC. The InCarda 2020 Warrant is exercisable immediately with an exercise price of $0.7328 per share. In September 2021, TRC and InCarda entered into an amendment to extend the expiration date of the InCarda 2020 Warrant from October 6, 2021 to March 31, 2022. On March 9, 2022, TRC and InCarda entered into an amendment to further extend the expiration date of the InCarda 2020 Warrant from March 31, 2022 to March 31, 2023. The InCarda 2020 Warrant is recorded at fair value and subject to remeasurement at each balance sheet date.

On March 9, 2022, TRC entered into a Note and Warrant Purchase Agreement (the “InCarda Agreement”) with InCarda to acquire a convertible promissory note (the “InCarda Convertible Note”) and warrants (the “InCarda 2022 Warrant”) for $0.7 million. The InCarda Convertible Note bears an annual interest rate of 6% and will convert into Series D preferred stock upon a qualified financing, non-qualified financing, or maturity conversion. A qualified financing is defined as the first issuance or series of related issuances by InCarda of its equity securities following March 9, 2022 from which InCarda receives immediately available gross proceeds of at least $10.0 million (excluding the aggregate amount of any notes converted into equity securities pursuant to the conversion of notes or any other debt securities converted into equity securities) (the “Qualified Financing Amount”). A non-qualified financing is defined as the first issuance or series of related issuances by InCarda of its equity securities following March 9, 2022 from which InCarda receives immediately available gross proceeds of less than the Qualified Financing Amount. The InCarda 2022 Warrant entitles TRC to purchase a number of shares of equity securities equal to 100% of the principal amount of the InCarda Convertible Note divided by the number of shares issued in InCarda’s next equity financing, which is defined as the earliest to occur of specific financing events, including capital raises through public offerings. The InCarda 2022 Warrant expires on March 9, 2027. The InCarda Convertible Note and InCarda 2022 Warrant are measured at fair value.

On June 15, 2022, the principal amount and the accrued interest of the InCarda Convertible Note were converted into equity securities. In addition, TRC participated in InCarda’s Series D preferred stock financing by investing $2.3 million. In connection with the new round of financing, InCarda recapitalized its equity structure resulting in TRC owning 4,093,886 shares of InCarda’s common stock, 37,350 shares of its Series A-1 preferred stock, 20,469,432 shares of its Series C preferred stock, 8,771,780 shares of its Series D-1 preferred stock, 3,369,802 shares of its Series D-2 preferred stock, a warrant to purchase 5,117,358 shares of its Series C preferred stock at $0.73 per share and a warrant to purchase 2,490,033 shares of its Series D-2 preferred stock at $0.26 per share.

As of June 30, 2022 and December 31, 2021, TRC held 8.9% and 13.0%, respectively, of InCarda equity ownership. The investment in InCarda does not provide TRC the ability to control or have significant influence over InCarda’s operations. Based on our evaluation, we determined that InCarda is a VIE, but TRC is not the primary beneficiary of the VIE. Under the measurement alternative, the equity investment is initially recorded at its allocated cost, but the carrying value may be adjusted through earnings upon an impairment or when there is an observable price change involving the same or a similar investment with the same issuer. Due to InCarda’s equity recapitalization in the second quarter of 2022, TRC reassessed the value of its investments in InCarda using the Option Pricing Model Backsolve valuation methodology. Key assumptions used in the valuation model include an expected holding period of two years, a risk free interest rate of 3.2%, a dividend yield of 0.0% and an estimated volatility of 122.0%. The estimated volatility is calculated based on the historical volatility of a selected peer group of public companies comparable to InCarda. We recognized an impairment charge of $9.0 million. There was no impairment or other change to the value of our investments in InCarda as of December 31, 2021.

As of June 30, 2022, we recorded $7.2 million in fair value of InCarda's Series C preferred stock, Series C warrants and Series D warrants (the "InCarda Preferred Stock Warrants"), and $3.2 million for InCarda's Series D-1 preferred stock, Series D-2 preferred stock, and common stock using the measurement alternative. As of December 31, 2021, we recorded $0.4 million in fair value of InCarda’s 2020 Warrants and $15.8 million for the investment in InCarda’s Series C preferred stock using the measurement alternative. During the three and six months ended June 30, 2022, we recorded $9.6 million and $9.0 million in net unrealized loss, respectively, as changes in fair values of equity and long-term investments, net on the unaudited condensed consolidated statements of income. During the three and six months ended June 30, 2021, we recorded $0.3 million and $0.7 million of unrealized loss, respectively, as changes in fair values of equity and long-term investments, net on the unaudited condensed consolidated statements of income.

Equity Investment in ImaginAb

During the first quarter of 2021, TRC entered into a securities purchase agreement with ImaginAb, Inc. to purchase 4,051,724 shares of ImaginAb Series C preferred stock for $4.7 million. On the same day, TRC also entered into a securities purchase agreement with one of ImaginAb’s common stockholders to purchase 4,097,157 shares of ImaginAb common stock for $1.3 million. ImaginAb is a privately held biotechnology company focused on clinically managing cancer and autoimmune diseases via molecular imaging. $0.4 million was incurred for investment due diligence costs and execution and recorded as part of the equity investment on the condensed consolidated balance sheets. As of June 30, 2022, one of ImaginAb’s five board members is designated by TRC. As of June 30, 2022 and December 31, 2021, TRC held 14.4% and 14.5% of ImaginAb equity ownership, respectively.

The investment in ImaginAb does not provide TRC the ability to control or have significant influence over ImaginAb’s operations. Based on our evaluation, we determined that ImaginAb is a VIE, but TRC is not the primary beneficiary of the VIE. Because ImaginAb’s equity securities are not publicly traded and do not have a readily determinable fair value, we have accounted for our investment in ImaginAb’s Series C preferred stock and common stock using the measurement alternative. Under the measurement alternative, the equity investment is initially recorded at its allocated cost, but the carrying value may be adjusted through earnings upon an impairment or when there is an observable price change involving the same or a similar investment with the same issuer. As of June 30, 2022 and December 31, 2021, $6.4 million was recorded as equity and long-term investments on the unaudited condensed consolidated balance sheets and there was no change to the fair value of our investment.

Convertible Promissory Note in Gate Neurosciences

During the fourth quarter of 2021, TRC entered into a Convertible Promissory Note Purchase Agreement with Gate Neurosciences, Inc. (“Gate”) to acquire a convertible promissory note (the “Gate Convertible Note”) with a principal amount of $15.0 million. Gate is a privately held biopharmaceutical company focused on developing the next generation of targeted nervous system therapies, leveraging precision medicine approaches to develop breakthrough drugs for psychiatric and neurologic diseases. The investment is intended to fund its ongoing development and research. The Gate Convertible Note bears an annual interest rate of 8% and will convert into shares of common stock of Gate upon a qualified event or into shares of shadow preferred stock of Gate (“Shadow Preferred”) upon a qualified financing. A qualifying event can be a qualified initial price offering, a qualified merger, or a merger with a special-purpose acquisition company (“SPAC”).

The number of common stock shares to be issued in a qualified event shall be equal to the amount due on the conversion date divided by the lesser of a capped conversion price (the “Capped Conversion Price”) and the qualified event price (the “Qualified Event Price”). The Capped Conversion Price is calculated as $50.0 million divided by the number of shares of common stock outstanding at such time on a fully diluted basis. The Qualified Event Price is the price per share determined by the qualified event. A qualified financing is a sale or series of sales of preferred stock where (i) at least 50 percent of counterparties are not existing shareholders, (ii) net proceeds to Gate are at least $35.0 million, and (iii) the stated or implied equity valuation of Gate is at least $80.0 million. Shadow Preferred means preferred stock having identical rights, preferences and restrictions as the preferred stock that would be issued in a qualified financing.

The investment in Gate does not provide TRC the ability to control or have significant influence over Gate’s operations. Based on our evaluation, we determined that Gate is a VIE, but TRC is not the primary beneficiary of the VIE. We have accounted for the Gate Convertible Note as a trading security, measured at fair value using a Monte Carlo simulation model with the probability of certain qualified events and the assumptions of equity value of Gate, risk-free rate, expected stock price volatility of its peer companies, and the time until a financing is raised. TRC has the right to designate one board member to Gate’s board. As of June 30, 2022, TRC has designated a board member to Gate’s board, which currently consists of three directors. As of June 30, 2022 and December 31, 2021, the fair value of the Gate Convertible Note was estimated at $15.2 million and $15.1 million, respectively, and recorded as equity and long-term investments on the unaudited condensed consolidated balance sheets. We recorded $0.3 million and $0.1 million unrealized gain, respectively, as changes in fair values of equity and long-term investments, net on the unaudited condensed consolidated statement of income for the three and six months ended June 30, 2022.

Equity Investment in Nanolive

On February 18, 2022, TRC entered into an investment and shareholders agreement with Nanolive SA (“Nanolive”) to purchase 18,750,000 shares of Nanolive Series C preferred stock for $9.8 million (equivalent to 9.0 million CHF). Nanolive SA is a Swiss privately held life sciences company focused on developing breakthrough imaging solutions that accelerate research in growth industries such as drug discovery and cell therapy. $0.7 million was incurred for investment due diligence costs and execution and recorded as part of the equity and long-term investment on the condensed consolidated balance sheets. TRC has the right to designate one member to Nanolive’s board. TRC also has the right to designate another member, who will be mutually acceptable to TRC and another majority common stockholder, to Nanolive’s board. As of June 30, 2022, no Innoviva designees are serving on Nanolive’s seven-member board. As of June 30, 2022, TRC held 16.1% of Nanolive equity ownership.

The investment in Nanolive does not provide TRC the ability to control or have significant influence over Nanolive’s operations. Based on our evaluation, we determined that Nanolive is a VIE, but TRC is not the primary beneficiary of the VIE. Because Nanolive’s equity securities are not publicly traded and do not have a readily determinable fair value, we have accounted for our investment in Nanolive’s Series C preferred stock using the measurement alternative. Under the measurement alternative, the equity investment is initially recorded at its allocated cost, but the carrying value may be adjusted through earnings upon an impairment or when there is an observable price change involving the same or a similar investment with the same issuer. As of June 30, 2022, $10.6 million was recorded as equity and long-term investments on the unaudited condensed consolidated balance sheets and there was no change to the fair value of our investment.

Fair Value Measurements

Our equity and long-term investments are measured at fair value on a recurring basis and our debt is carried at amortized cost basis. Equity investments accounted for using the measurement alternative are valued using Level 3 inputs.

	Estimated Fair Value Measurements as of June 30, 2022 Using:
	Quoted Price in Active Markets for		Significant Other		Significant
	Identical		Observable		Unobservable
Types of Instruments	Assets		Inputs		Inputs
(In thousands)	Level 1		Level 2		Level 3		Total
Assets
Money market funds	$	156,460	$	—	$	—	$	156,460
Investments held by ISP Fund LP (1)		304,810		—		2,053		306,863
Equity investment - Armata Common Stock		97,549		—		—		97,549
Equity investment - Armata Warrants		—		47,148		—		47,148
Equity investment - InCarda Series C Preferred Stock						6,808		6,808
Equity investment - InCarda Preferred Stock Warrants						342		342
Convertible debt investment - Gate Note		—		—		15,200		15,200
Total assets measured at estimated fair value	$	558,819	$	47,148	$	24,403	$	630,370
Debt
2023 Notes	$	—	$	95,606	$	—	$	95,606
2025 Notes		—		214,443		—		214,443
2028 Notes		—		225,530		—		225,530
Total fair value of debt	$	—	$	535,579	$	—	$	535,579

(1)The investments held by ISP Fund LP, consisted of $201.6 million in equity investments, which included a private placement position of $2.1 million, $35.3 million in money market funds and $70.0 million in cash. Our total capital contribution of $300.0 million is subject to a 36-month lock-up period from the date of such capital contributions.

	Estimated Fair Value Measurements as of December 31, 2021 Using:
	Quoted Price
	in Active		Significant
	Markets for		Other		Significant
	Identical		Observable		Unobservable
Types of Instruments	Assets		Inputs		Inputs
(In thousands)	Level 1		Level 2		Level 3		Total
Assets
Money market funds	$	145,132	$	—	$	—	$	145,132
Investments held by ISP Fund LP (1)		193,677		—		2,068		195,745
Equity investment - Armata Common Stock		88,101		—		—		88,101
Equity investment - Armata Warrants		—		58,595		—		58,595
Equity investment - Entasis Common Stock		62,794		—		—		62,794
Equity investment - Entasis Warrants		—		40,914		—		40,914
Equity investment - InCarda Warrants		—		—		411		411
Convertible debt investment - Gate Note		—		—		15,100		15,100
Total assets measured at estimated fair value	$	489,704	$	99,509	$	17,579	$	606,792
Debt
2023 Notes	$	—	$	261,769	$	—	$	261,769
2025 Notes		—		234,498		—		234,498
Total fair value of debt	$	—	$	496,267	$	—	$	496,267

(1)The investments held by ISP Fund LP, consisted of $192.2 million equity investments and $3.5 million money market funds, are subject to a 36-month lock-up period from our initial contribution date, December 11, 2020.

The fair values of our equity investments in Armata’s common stock and publicly traded investments held by ISP Fund LP are based on the quoted prices in active markets and are classified as Level 1 financial instruments. The fair values of the warrants of Armata classified within Level 2 are based upon observable inputs that may include benchmark yields, reported trades, broker/dealer quotes, issuer spreads, two-sided markets, benchmark securities, bids, offers, and reference data including market research publications.

InCarda’s equity securities, the Gate Convertible Note, and private placement positions held by ISP Fund LP are classified as Level 3 financial instruments as these securities are not publicly traded and the assumptions used in the valuation model for valuing these securities are based on significant unobservable and observable inputs including those of publicly traded peer companies.

The fair values of our 2023 Notes, 2025 Notes and 2028 Notes are based on recent trading prices of the respective instruments.

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Goodwill and Intangible Assets

6 Months Ended

Jun. 30, 2022

Goodwill and Intangible Assets Disclosure [Abstract]

Goodwill and Intangible Assets

6. Goodwill and Intangible Assets

Goodwill and intangible assets acquired in our consolidation of Entasis were recognized at fair value as of the consolidation date, February 17, 2022. The carrying amount of goodwill as of June 30, 2022 was $5.5 million. Intangible assets with definite lives are amortized over their estimated useful lives. The carrying basis and accumulated amortization of recognized intangible assets as of June 30, 2022 were as follows:

	Carrying
(In thousands)	Amount
Intangible assets with indefinite life	$	69,500
Intangible asset with determinable life		35,500
Total	$	105,000

All intangible assets are related to in-process research and development. The intangible assets with indefinite life consist of antibacterial therapeutic products. The intangible asset with determinable life consists of a contract, which commences in 2023. The useful life of this intangible asset will be determined upon commercialization of the underlying product candidate. Thus, no amortization expense of determinable assets was recognized during the period ended June 30, 2022.

Goodwill and indefinite-lived intangible assets are not amortized but are tested at least annually for impairment, or more frequently if triggering events occur, based on the estimated fair value of the intangible asset.

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Balance Sheet Components

6 Months Ended

Jun. 30, 2022

Balance Sheet Related Disclosures [Abstract]

Balance Sheet Components

7. Balance Sheet Components

Other Accrued Liabilities

Other accrued liabilities consisted of the following:

	June 30,		December 31,
(in thousands)	2022		2021
Accrued contract manufacturing	$	4,621	$	—
Accrued clinical		994		—
Accrued research		330		—
Accrued professional services		3,829		894
Current portion of lease liabilities		687		106
Liabilities for unsettled security transactions		6,328		—
Other		355		9
Total other accrued liabilities	$	17,144	$	1,009

The other accrued liabilities balance as of June 30, 2022 included $8.2 million related to Entasis.

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Stock-Based Compensation

6 Months Ended

Jun. 30, 2022

Share-Based Payment Arrangement [Abstract]

Stock-Based Compensation

8. Stock-Based Compensation

Stock- Based Compensation Expense

The following table summarizes stock-based compensation expense, which included $0.7 million and $1.0 million, respectively, related to Entasis’ equity awards, for the three and six months ended June 30, 2022:

	Three Months Ended June 30,				Six Months Ended June 30,
(In thousands)	2022		2021		2022		2021
General and administrative	$	1,030	$	470	$	1,818	$	921
Research and development		320		—		486		—
Total	$	1,350	$	470	$	2,304	$	921

Valuation Assumptions

Black-Scholes-Merton assumptions used in calculating the estimated value of stock options granted by Innoviva on the date of grant were as follows:

	Three Months Ended June 30,						Six Months Ended June 30,
	2022			2021			2022			2021
Risk-free interest rate	2.84% - 3.03%			1.07%			1.6% - 3.03%			1.07% - 1.13%
Expected term (in years)	5.50 - 6.11				6.00		5.50 - 6.11				6.00
Volatility	38.8% - 39.0%				45.0	%	38.8% - 40.5%				45.0	%
Dividend yield		0.0	%		0.0	%		0.0	%		0.0	%
Weighted-average estimated fair value of stock options granted	$6.98 - $7.18			$	5.80		$6.98 - $7.73			$	5.61

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Debt

6 Months Ended

Jun. 30, 2022

Debt Disclosure [Abstract]

Debt

9. Debt

Our debt consisted of the following:

	June 30,			December 31,
(In thousands)	2022			2021
2023 Notes	$	96,204		$	240,984
2025 Notes		192,500			192,500
2028 Notes		261,000			—
Total debt		549,704			433,484
Less: Unamortized debt discount and issuance costs		(10,454	)		(38,831	)
Total debt, net	$	539,250		$	394,653
Less: Current portion of long-term debt, net		96,072			—
Total long-term debt, net	$	443,178		$	394,653

Convertible Subordinated Notes Due 2023

In January 2013, we completed an underwritten public offering of $287.5 million aggregate principal amount of our 2023 Notes, which will mature on January 15, 2023. The financing raised proceeds, net of issuance costs, of approximately $281.2 million, less $36.8 million to purchase two privately negotiated capped call option transactions in connection with the issuance of the notes. The 2023 Notes bear interest at the rate of 2.125% per year that is payable semi-annually in arrears in cash on January 15 and July 15 of each year, beginning on July 15, 2013.

At the option of the holders, the 2023 Notes may be converted into fully paid and non-assessable shares of our common stock prior to the close of the business on the second business day immediately preceding the final maturity date. The initial conversion rate was 35.9903 shares per $1,000 principal amount of the 2023 Notes, subject to customary anti-dilution adjustment in certain circumstances, which represented an initial conversion price of approximately $27.79 per share.

In event of default or a fundamental change (as defined in the indenture governing the 2023 Notes), holders of the 2023 Notes may require us to repurchase all or a portion of their 2023 Notes at price equal to 100% of the principal amount of the 2023 Notes, plus any accrued and unpaid interest.

In connection with the offering of the 2023 Notes, we entered into two privately negotiated capped call option transactions with a single counterparty. The capped call option transaction is an integrated instrument consisting of a call option on our common stock purchased by us with a strike price equal to the initial conversion price of $27.79 per share for the underlying number of shares and a cap price of $38.00 per share, both of which are subject to adjustments consistent with the 2023 Notes. The cap component is economically equivalent to a call option sold by us for the underlying number of shares with an initial strike price of $38.00 per share. As an integrated instrument, the settlement of the capped call coincides with the due date of the convertible debt. Upon settlement, we would receive from our hedge counterparty a number of shares of our common shares that would range from zero, if the stock price was below $27.79 per share, to a maximum of 2,779,659 shares, if the stock price is above $38.00 per share. However, if the market price of our common stock, as measured under the terms of the capped call transactions, exceeds $38.00 per share, there is no incremental anti-dilutive benefit from the capped call.

As a result of the partial conversion by certain holders of the 2023 Notes in July 2014, and dividends declared and paid in 2014 and 2015, the conversion rate with respect to our 2023 Notes was adjusted in total to 50.5818 shares of our common stock per $1,000 principal amount of the 2023 Notes, which represents a conversion price of approximately $19.77 per share. As a result of the conversion rate adjustments, the capped call strike price and cap price were also adjusted to $19.77 and $27.04, respectively.

During 2016, we retired a portion of our 2023 Notes with a face value of $14.1 million and carrying value of $13.9 million by way of purchase in the open market.

On March 7, 2022, we used $165.6 million from the sale of the 2028 Notes to repurchase 60% of the 2023 Notes with a face value of $144.8 million. The carrying value of the repurchased 2023 Notes was $144.5 million. Accrued interest was $0.4 million and unamortized debt issuance costs were $0.3 million on the date of repurchase. We recognized a loss on the extinguishment of the 2023 Notes of $20.7 million in other expense, net in the unaudited condensed consolidated statement of operations. The repurchase reduced the outstanding principal balance to $96.2 million and unamortized debt issuance costs to $0.2 million. The effective interest rate of the 2023 Notes changed to 2.37%.

On April 18, 2022, certain 2023 Notes holders converted their notes of $3.0 thousand into Innoviva’s common stock. The outstanding principal balance was reduced slightly to $96.2 million.

Our outstanding 2023 Notes balances consisted of the following:

	June 30,			December 31,
(In thousands)	2022			2021
Liability component
Principal	$	96,204		$	240,984
Debt issuance costs, net		(132	)		(620	)
Net carrying amount	$	96,072		$	240,364

The following table sets forth total interest expense recognized related to the 2023 Notes for the three and six months ended June 30, 2022 and 2021:

	Three Months Ended June 30,				Six Months Ended June 30,
(In thousands)	2022		2021		2022		2021
Contractual interest expense	$	511	$	1,280	$	1,595	$	2,560
Amortization of debt issuance costs		59		147		181		288
Total interest and amortization expense	$	570	$	1,427	$	1,776	$	2,848

Convertible Senior Notes Due 2025

On August 7, 2017, we completed a private placement of $192.5 million aggregate principal amount of our 2025 Notes. The proceeds include the 2025 Notes sold pursuant to the $17.5 million over-allotment option granted by us to the initial purchasers, which option was exercised in full. The 2025 Notes were sold in a private placement to qualified institutional buyers pursuant to Rule 144A under the Securities Act. The 2025 Notes are senior unsecured obligations and bear interest at a rate of 2.5% per year, payable semi-annually in arrears on February 15 and August 15 of each year, beginning on February 15, 2018.

The 2025 Notes are convertible, based on the applicable conversion rate, into cash, shares of our common stock or a combination thereof, at our election. The initial conversion rate for the 2025 Notes is 57.9240 shares of our common stock per $1,000 principal amount of the 2025 Notes (which is equivalent to an initial conversion price of approximately $17.26 per share), representing a 30.0% conversion premium over the last reported sale price of the Company’s common stock on August 1, 2017, which was $13.28 per share. The conversion rate is subject to customary anti-dilution adjustments in certain circumstances. The 2025 Notes will mature on August 15, 2025, unless repurchased or converted in accordance with their terms prior to such date. Prior to February 15, 2025, the 2025 Notes will be convertible at the option of the holders only upon the occurrence of specified events and during certain periods, as described below. From, and including, February 15, 2025, until the close of business on the second scheduled trading day immediately preceding the maturity date, the 2025 Notes will be convertible at any time.

Holders of the 2025 Notes may convert all or a portion of their 2025 Notes prior to the close of business on February 15, 2025 only under the following circumstances:

•after September 30, 2017, if our closing common stock price for at least 20 days out of the most recent 30 consecutive trading days of the preceding quarter is greater than 130% of the current conversion price of the 2025 Notes;

•for five consecutive business days, if the average trading price per $1,000 of Notes during the prior 10 consecutive trading days is less than 98% of the product of the our closing common stock price and the conversion rate of the 2025 Notes on such day;

•upon the occurrence of specified corporate events, including certain distributions, the occurrence of a fundamental changes (as defined in the indenture governing the 2025 Notes) or a transaction resulting in our common stock converting into other securities or property or assets.

On or after February 15, 2025, holders of the 2025 Notes may convert their 2025 Notes at any time until the close of business on the second scheduled trading day immediately preceding the maturity date of the 2025 Notes.

In event of default or a fundamental change (as defined above), holders of the 2025 Notes may require us to repurchase all or a portion of their 2025 Notes at price equal to 100% of the principal amount of the 2025 Notes, plus any accrued and unpaid interest.

Effective January 1, 2022, we adopted ASU 2020-06 using a modified retrospective method, under which financial results reported in prior periods were not adjusted. The adoption of ASU 2020-06 had a material impact on the 2025 notes.

Prior to the adoption of the standard, we separately account for the liability and equity components of the 2025 Notes by allocating the proceeds between the liability component and the embedded conversion option (“equity component”) due to our ability to settle the conversion obligation of the 2025 Notes in cash, common stock or a combination of cash and common stock, at our option. The carrying amount of the liability component was calculated by measuring the fair value of a similar liability that does not have an associated convertible feature using the income approach. The allocation was performed in a manner that reflected our non-convertible debt borrowing rate for similar debt. The equity component of the 2025 Notes of $67.3 million was recognized as a debt discount and represents the difference between the proceeds from the issuance of the 2025 Notes and the fair value of the liability of the 2025 Notes on the date of issuance. The excess of the principal amount of the liability component over its carrying amount (“debt discount”) is amortized to interest expense using the effective interest method over the term of the 2025 Notes. The equity component is not remeasured as long as it continues to meet the conditions for equity classification. Additionally, we separated the total issuance costs of $5.4 million incurred into liability and equity components in proportion to the allocation of the initial proceeds, resulting in liability issuance costs of $3.5 million and equity issuance costs of $1.9 million. Issuance costs attributable to the liability component were amortized on a straight-line basis, which approximated the effective interest rate method, to interest expense over the term of the 2025 Notes. The issuance costs attributable to the equity component were netted against the equity component in additional paid-in capital. The effective interest rate of the liability component of the 2025 Notes was 8.87%.

Upon adoption of ASU 2020-06 on January 1, 2022, we combined the liability and equity components of the 2025 Notes assuming that the instrument was accounted for as a single liability from inception to the date of adoption. We similarly combined the liability and equity components of the issuance costs. The issuance costs are presented as a deduction from the outstanding principal balance of the 2025 Notes, and are amortized on a straight-line basis over the term of the 2025 Notes under the effective interest rate method. As of January 1, 2022, the effective interest rate on the 2025 Notes was 2.88%.

Our outstanding 2025 Notes balances consisted of the following:

	June 30,			December 31,
(In thousands)	2022			2021
Liability component
Principal	$	192,500		$	192,500
Debt discount and issuance costs, net		(2,265	)		(38,211	)
Net carrying amount	$	190,235		$	154,289
Equity component, net	$	—		$	65,361

The following table sets forth total interest expense recognized related to the 2025 Notes for the three and six months ended June 30, 2022 and 2021:

	Three Months Ended June 30,				Six Months Ended June 30,
(In thousands)	2022		2021		2022		2021
Contractual interest expense	$	1,203	$	1,203	$	2,406	$	2,406
Amortization of debt issuance costs		172		162		343		321
Amortization of debt discount		—		1,951		—		3,862
Total interest and amortization expense	$	1,375	$	3,316	$	2,749	$	6,589

Convertible Senior Notes Due 2028

In March 2022, we completed a private placement of $261.0 million aggregate principal amount of our 2028 Notes, which will mature on March 15, 2028. The proceeds include the 2028 Notes sold pursuant to the $45.0 million over-allotment option granted by us to the initial purchasers, of which $36.0 million was exercised. The 2028 Notes were sold in a private placement to qualified institutional buyers pursuant to Rule 144A under the Securities Act.

The net proceeds from the sale of the $261.0 million aggregate principal amount of 2028 Notes were approximately $252.6 million after deducting the initial purchasers’ discounts and commissions and our estimated offering expenses. We used approximately $21.0 million of the net proceeds from the offering to fund the cost of entering into the capped call transactions described below. In addition, we used $165.6 million of the remaining net proceeds to repurchase $144.8 million aggregate principal amount of the 2023 Notes in separate and individually negotiated transactions with certain holders of the 2023 Notes, which closed concurrently with the issuance of the 2028 Notes. We expect to use the remaining net proceeds for general corporate purposes.

The 2028 Notes bear interest at an annual rate of 2.125% that is payable semi-annually in arrears in cash on March 15 and September 15 of each year, beginning on September 15, 2022.

The 2028 Notes are convertible, based on the applicable conversion rate, into cash, shares of our common stock or a combination thereof, at our election. The initial conversion rate was 38.1432 shares per $1,000 principal amount of the 2028 Notes, subject to customary anti-dilution adjustment in certain circumstances, which represented an initial conversion price of approximately $26.22 per share.

Prior to September 15, 2027, the 2028 Notes will be convertible at the option of the holders only upon the occurrence of specified events and during certain periods, and will be convertible on or after September 15, 2027, at any time until the close of business on the second scheduled trading day immediately preceding the maturity date of the Notes.

Holders of the 2028 Notes may convert all or a portion of their 2028 Notes prior to the close of business on September 15, 2027, only under the following circumstances:

•after March 31, 2022, if our closing common stock price for at least 20 days out of the most recent 30 consecutive trading days of the preceding quarter is greater than 130% of the current conversion price of the 2028 Notes;

•for five consecutive business days, if the average trading price per $1,000 of Notes during the prior 10 consecutive trading days is less than 98% of the product of our closing common stock price and the conversion rate of the 2028 Notes on such day;

•upon the occurrence of specified corporate events, including certain distributions, the occurrence of a fundamental changes (as defined in the indenture governing the 2028 Notes) or a transaction resulting in our common stock converting into other securities or property or assets.

On or after September 15, 2027, holders of the 2028 Notes may convert their 2028 Notes at any time until the close of the business on the second day immediately preceding the maturity date of the 2028 Notes.

The 2028 Notes will be redeemable, in whole or in part, at our option at any time, and from time to time, on or after March 20, 2025, and on or before the 75th scheduled trading day immediately before the maturity date but only if the last reported sale price per share of our common stock exceeds 130% of the conversion price for a specified period of time. The redemption price will be equal to the principal amount of the 2028 Notes to be redeemed, plus accrued and unpaid interest, if any, to, but excluding, the redemption date. In addition, calling any 2028 Note for redemption will constitute a make-whole fundamental change (as defined in the indenture governing the 2028 Notes) with respect to that 2028 Note, in which case the conversion rate applicable to the conversion of that 2028 Note will be increased in certain circumstances if it is converted after it is called for redemption.

If we undergo a fundamental change, subject to certain conditions, holders may require us to purchase for cash all or any portion of their 2028 Notes. The fundamental change purchase price will be 100% of the principal amount of the 2028 Notes to be purchased plus any accrued and unpaid interest to, but excluding, the fundamental change purchase date.

The indenture governing the 2028 Notes contains customary terms and covenants, including a merger covenant and that upon certain events of default occurring and continuing, either the Trustee or the holders of at least 25% of the aggregate principal amount of the outstanding Notes may declare 100% of the principal of, and accrued and unpaid interest, if any, on, all the Notes to be due and payable immediately.

In connection with the offering of the 2028 Notes, we entered into privately negotiated capped call transactions. The cap price of the capped call transaction is initially $33.9850 per share and is subject to certain adjustments under the terms of the capped call transactions. The capped call transactions cover, subject to customary adjustments, the number of shares of common stock initially underlying the 2028 Notes. The capped call transactions are expected generally to reduce potential dilution to our common stock upon conversion of the 2028 Notes or at our election (subject to certain conditions) offset any cash payments we are required to make in excess of the aggregate principal amount of converted 2028 Notes, as the case may be, with such reduction or offset subject to a cap.

As of June 30, 2022, the effective interest rate on the 2028 Notes was 2.70%.

Our outstanding 2028 Notes balance as of June 30, 2022 consisted of the following:

(In thousands)	June 30, 2022
Liability component
Principal	$	261,000
Debt issuance costs, net		(8,057	)
Net carrying amount	$	252,943

The following table sets forth total interest expense recognized related to the 2028 Notes from the date of issuance through June 30, 2022:

	Three Months Ended June 30,		Six Months Ended June 30,
(In thousands)	2022		2022
Contractual interest expense	$	1,387	$	1,756
Amortization of debt issuance costs		323		407
Total interest and amortization expense	$	1,710	$	2,163

Debt Maturities

The aggregate scheduled maturities of our convertible debt as of June 30, 2022 were as follows:

(In thousands)	June 30, 2022
Years ending December 31:
Remainder of 2022	$	—
2023		96,204
2024		—
2025		192,500
2026		—
Thereafter		261,000
Total	$	549,704

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Commitments and Contingencies

6 Months Ended

Jun. 30, 2022

Commitments and Contingencies Disclosure [Abstract]

Commitments and Contingencies

10. Commitments and Contingencies

Operating Lease

Our operating leases include Entasis’ facility lease (the “Entasis Lease”) consisting of 20,062 square feet of office and laboratory space in Waltham, Massachusetts. In February 2022, Entasis decided to exercise a renewal option for the Entasis Lease to extend the lease term for three additional years through 2025 and subsequently signed the Second Amendment in April 2022. As of June 30, 2022, the weighted average remaining lease term was 2.8 years and the estimated weighted-average incremental borrowing rate used to determine the operating lease right-of-use assets and lease liabilities was 7.8%.

We also lease approximately 2,111 square feet of office space in Burlingame, California.

The following table summarizes our operating leases as presented in the unaudited condensed consolidated balance sheets:

	June 30,		December 31,
(In thousands)	2022		2021
Assets
Right-of-use assets	$	3,545	$	97
Liabilities
Lease liabilities, current	$	687	$	106
Lease liabilities, long-term		3,091		—
Total lease liabilities	$	3,778	$	106

Future minimum operating lease payments on the Entasis Lease as of June 30, 2022 were as follows:

(In thousands)	June 30, 2022
Years ending December 31:
Remainder of 2022	$	368
2023		1,249
2024		1,269
2025		1,289
Total undiscounted lease payments		4,175
Less: imputed interest		(442	)
Total operating lease liabilities	$	3,733

Future minimum operating lease payments on our corporate headquarters in Burlingame, California as of June 30, 2022 were as follows:

(In thousands)	June 30, 2022
Years ending December 31:
Remainder of 2022	$	46
Thereafter		—
Total	$	46

Legal Proceedings

From time to time, the Company is involved in legal proceedings in the ordinary course of its business. Currently, we believe that no litigation or arbitration, either individually or in the aggregate, to which we are presently a party is likely to have a material adverse effect on our operating results or financial position.

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Income Taxes

6 Months Ended

Jun. 30, 2022

Income Tax Disclosure [Abstract]

Income Taxes

11. Income Taxes

We recorded a provisional income tax benefit of $0.9 million for the three months ended June 30, 2022 and provisional income tax expense of $6.0 million for the six months ended June 30, 2022, compared to provisional income tax expense of $25.3 million and $45.1 million for the three and six months ended June 30, 2021 respectively. The Company’s effective income tax rate for the six months ended June 30, 2022 was 4.3%, compared to 18.6% for the same period in 2021. The income tax expense for the six months ended June 30, 2022 and 2021 was determined based upon estimates of the Company’s effective income tax rates in various jurisdictions. Our effective income tax rate for the six months ended June 30, 2022 was lower than the U.S. federal statutory income tax rate due primarily to noncontrolling interest and a decrease in the fair value of our equity investments.

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Subsequent Events

6 Months Ended

Jun. 30, 2022

Subsequent Events [Abstract]

Subsequent Events

12. Subsequent Events

On July 11, 2022, we announced the completion of our acquisition of Entasis by acquiring all the issued and outstanding equity securities of Entasis not already owned by our company for $2.20 per share for a consideration of $42.4 million.

On July 11, 2022, we also entered into a definitive merger agreement, whereby we will acquire La Jolla Pharmaceutical Company (“La Jolla”), a company dedicated to the commercialization of innovative therapies that improve outcomes in patients suffering from life-threatening diseases. Under the terms of the agreement, we will acquire all of the outstanding shares of La Jolla for $6.23 per share in cash subject to certain closing conditions.

On July 13, 2022, we announced that we entered into an agreement to sell our 15% economic stake in TRC, which receives royalties stemming from sales of TRELEGY® ELLIPTA®, to Royalty Pharma plc for an upfront cash payment of approximately $282.0 million and a potential $50.0 million contingent sales-based milestone payment. Under the terms of the agreement, TRC also transferred to Innoviva all of TRC's ownership interests and investments in InCarda, ImaginAb, Gate Neurosciences and Nanolive. We retain our royalty rights with respect to RELVAR®/BREO® ELLIPTA® and ANORO® ELLIPTA®, as well as the GSK Agreements associated with the retained products. The transaction was closed on July 20, 2022.

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Description of Operations and Summary of Significant Accounting Policies (Policies)

6 Months Ended

Jun. 30, 2022

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Basis of Presentation

Basis of Presentation

The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America (“US GAAP”) for interim financial information. Accordingly, they do not include all of the information and notes required by US GAAP for complete financial statements. In our opinion, the unaudited condensed consolidated financial statements have been prepared on the same basis as audited consolidated financial statements and include all adjustments, consisting of only normal recurring adjustments, necessary for the fair presentation of our financial position, results of operations, comprehensive income and cash flows. The interim results are not necessarily indicative of the results of operations to be expected for the year ending December 31, 2022 or any other period.

The accompanying unaudited condensed consolidated financial statements include the accounts of Innoviva, our wholly-owned subsidiaries and certain variable interest entities for which we are the primary beneficiary. All intercompany balances and transactions have been eliminated in consolidation. For consolidated entities where we own or are exposed to less than 100% of the economics, we record net income attributable to noncontrolling interest in our unaudited condensed consolidated statements of income equal to the percentage of the economic or ownership interest retained in such entities by the respective noncontrolling parties. The accompanying unaudited condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and notes thereto included in our Annual Report on Form 10-K for the year ended December 31, 2021 filed with the Securities and Exchange Commission (“SEC”) on February 28, 2022, and as amended on March 17, 2022 (“2021 Form 10-K”).

Prior Period Immaterial Correction

Prior Period Immaterial Correction

Subsequent to the issuance of the unaudited condensed consolidated financial statements for the three and six months ended June 30, 2021, the Company identified that (i) purchases of equity investments managed by ISP Fund LP for $142.6 million, (ii) sales of equity investments managed by ISP Fund LP for $18.5 million, and (iii) purchase and sales of other investments managed by ISP Fund LP, net for $234.1 million were incorrectly netted in the unaudited condensed consolidated statement of cash flows within the distribution of equity and long-term investments line item. The Company has corrected the presentation in the accompanying unaudited condensed consolidated statement of cash flows for the six months ended June 30, 2021 from amounts previously reported to present such line items separately. The correction did not impact total cash flows from investing activities or the unaudited condensed consolidated balance sheet, statement of income, or statement of comprehensive income. Management assessed the correction on a quantitative and qualitative basis and determined that it is immaterial to the prior period unaudited condensed consolidated financial statements.

Use of Management's Estimates

Use of Management’s Estimates

The preparation of unaudited condensed consolidated financial statements in conformity with US GAAP requires management to make estimates and assumptions that affect the amounts reported in the unaudited condensed consolidated financial statements and accompanying notes. Actual results could differ materially from those estimates. Management evaluates its significant accounting policies and estimates on an ongoing basis. We base our estimates on historical experience and other relevant assumptions that we believe to be reasonable under the circumstances. These estimates also form the basis for making judgments about the carrying values of assets and liabilities when these values are not readily apparent from other sources.

Certain Risks and Concentrations

Certain Risks and Concentrations

Our financial instruments that are exposed to concentrations of credit risk consist primarily of cash and cash equivalents, marketable securities, equity and long-term investments. Although we deposit our cash with multiple financial institutions, our deposits, at times, may exceed federally insured limits.

Segment Reporting

Segment Reporting

We operate in a single segment, which is to provide capital return to stockholders by maximizing the potential value of our respiratory assets partnered with GSK. Revenues are generated from our collaborative arrangements and royalty payments from GSK, located in Great Britain. Our facilities are located within the United States.

Variable Interest Entities

Variable Interest Entities

We evaluate our ownership, contractual and other interest in entities to determine if they are a variable interest entity (“VIE”). We evaluate whether we have a variable interest in those entities and the nature and extent of those interests. Based on our evaluation, if we determine we are the primary beneficiary of a VIE, we consolidate the entity in our financial statements.

Equity and Long-Term Investments

Equity and Long-Term Investments

We invest from time to time in equity and debt securities of private or public companies. If we determine that we have control over these companies under either voting or VIE models, we include them in our unaudited condensed consolidated financial statements. If we determine that we do not have control over these companies under either voting or VIE models, we then determine if we have an ability to exercise significant influence via voting interests, board representation or other business relationships.

We may account for the investments where we exercise significant influence using either an equity method of accounting or at fair value by electing the fair value option under Accounting Standards Codification (“ASC”) Topic 825, Financial Instruments. If the fair value option is applied to an investment that would otherwise be accounted for under the equity method, we apply it to all our financial interests in the same entity (equity and debt, including guarantees) that are eligible items. All gains and losses from fair value changes, unrealized and realized, are presented as changes in fair values of equity and long-term investments, net on the unaudited condensed consolidated statements of income.

If we conclude that we do not have an ability to exercise significant influence over an investee, we may elect to account for the security without a readily determinable fair value using the measurement alternative under ASC Topic 321, Investments - Equity Securities. This measurement alternative allows us to measure the equity investment at its cost minus impairment, if any, plus or minus changes resulting from observable price changes in orderly transactions for the identical or a similar investment of the same issuer.

We also invest in ISP Fund LP, which investments consist of money market funds and equity securities in the healthcare, pharmaceutical and biotechnology industries. Pursuant to the Partnership Agreement entered in December 2020, we became a limited partner of this partnership, and our contributions are subject to a 36-month lock-up period which restriction prevents us from having control and access to the contributions and related investments. These investments are classified as long-term investments on the unaudited condensed consolidated balance sheets.

Revenue Recognition

Revenue Recognition

Revenue is recognized when our customer obtains control of promised goods or services, in an amount that reflects the consideration which we expect to receive in exchange for those goods or services. Revenue is recognized through a five-step process: (i) identify the contract with the customer; (ii) identify the performance obligations in the contract; (iii) determine the transaction price for the contract; (iv) allocate the transaction price to the performance obligations in the contract; and (v) recognize revenue as a performance obligation is satisfied.

We recognize the royalty revenue on net sales of products with respect to which we have contractual royalty rights in the period in which the royalties are earned. The net sales reports provided by our partner are based on its methodology and assumptions to estimate rebates and returns, which it monitors and adjusts regularly in light of contractual and legal obligations, historical trends, past experience and projected market conditions. Our partner may make significant adjustments to its sales based on actual results recorded, which could cause our royalty revenue to fluctuate. We have the ability to conduct periodic royalty audits to evaluate the information provided by our partner. Royalties are recognized net of amortization of capitalized fees associated with any approval and launch milestone payments made to GSK.

Research and Development Costs

Research and Development Costs

Research and development costs are expensed in the period that services are rendered or goods are received. Research and development costs consist of salaries and benefits, laboratory supplies and facility costs, as well as fees paid to third parties that conduct certain research and development activities on behalf of the Company’s consolidated variable interest entity, net of certain external research and development costs reimbursed under the collaboration arrangements of the Company’s consolidated variable interest entity. Non-refundable pre-payments for goods or services that will be used or rendered for future research and development activities are deferred. The Company’s consolidated variable interest entity also utilizes significant judgment and estimates to record accruals for estimated ongoing research costs based on the progress of the studies.

Goodwill and Intangible Assets

Goodwill and Intangible Assets

Goodwill is recognized as the excess of the purchase price of an acquired entity over the fair value of amount assigned to assets acquired and liabilities assumed in a business combination. Goodwill and intangible assets with indefinite lives is subject to impairment testing at least annually and will be tested for impairment between annual tests if a triggering event occurs, such as changes due to circumstances that would indicate an impairment of the carrying value. Significant judgments are involved in determining if an indicator of impairment has occurred. Intangible assets with definite lives are amortized on a straight-line basis over the remaining useful life of the intangible asset.

Operating Leases

Operating Leases

We account for our leases in accordance with Financial Accounting Standards Board (“FASB”) Accounting Standards Codification (“ASC”) 842, “Leases” (“ASC 842”). Right-of-use assets represent our right to use an underlying asset over the lease term and include any lease payments made prior to the lease commencement date and are reduced by lease incentives. Lease liabilities represent the present value of the total lease payments over the lease term, calculated using an estimated incremental borrowing rate. Lease expense is recognized on a straight-line basis over the expected lease term.

Accounting Pronouncement Adopted by the Company

Accounting Pronouncement Adopted by the Company

In August 2020, the FASB issued ASU 2020-06, Debt-Debt with Conversion and Other Options (Subtopic 470-20) and Derivatives and Hedging-Contracts in Entity’s Own Equity (Subtopic 815-40): Accounting for Convertible Instruments and Contracts in an Entity’s Own Equity, which is intended to simplify the accounting for convertible instruments by removing certain separation models in Subtopic 470-20 for convertible instruments. Consequently, a convertible debt instrument will be accounted for as a single liability measured at its amortized cost, as long as no other features require bifurcation and recognition as derivatives. The new standard also requires the if-converted method to be used to calculate diluted earnings per share (“EPS”) for convertible instruments.

Effective January 1, 2022, we adopted the new standard using the modified retrospective approach and assessed the effect of this adoption on the accounting for our outstanding convertible notes. The effect of the adoption on our 2025 Notes (as defined below) resulted in a decrease to the opening balance of accumulated deficit of $37.2 million, a reduction to additional paid-in capital of $65.4 million, an increase to the balance of the notes by an aggregate amount of $35.6 million, and an increase to deferred tax assets of $7.4 million. The dilutive EPS of our 2025 Notes will be computed under the if-converted method going forward. There was no financial impact from the implementation of the standard for our 2023 Notes (as defined below). Refer to Note 8, “Debt” for more information.

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Net Income Per Share (Tables)

6 Months Ended

Jun. 30, 2022

Earnings Per Share [Abstract]

Schedule of computation of basic and diluted net income per share

The following table shows the computation of basic and diluted net income per share for the three and six months ended June 30, 2022 and 2021:

	Three Months Ended June 30,				Six Months Ended June 30,
(In thousands except per share data)	2022		2021		2022		2021
Numerator:
Net income attributable to Innoviva stockholders, basic	$	939	$	88,948	$	16,712	$	183,071
Add: interest expense on 2023 Notes		570		1,163		1,591		2,367
Add: interest expense on 2025 Notes		1,375		—		2,539		—
Add: interest expense on 2028 Notes		1,709		—		2,093		—
Net income attributable to Innoviva stockholders, diluted	$	4,593	$	90,111	$	22,935	$	185,438
Denominator:
Weighted-average shares used to compute basic net income    per share attributable to Innoviva stockholders		69,643		88,423		69,594		94,858
Dilutive effect of 2023 Notes		4,866		12,189		7,511		12,189
Dilutive effect of 2025 Notes		11,150		—		11,150		—
Dilutive effect of 2028 Notes		9,955		—		6,360		—
Dilutive effect of options and awards granted under equity    incentive plan and employee stock purchase plan		39		27		77		49
Weighted-average shares used to compute diluted net income    per share attributable to Innoviva stockholders		95,653		100,639		94,692		107,096
Net income per share attributable to Innoviva stockholders
Basic	$	0.01	$	1.01	$	0.24	$	1.93
Diluted	$	0.05	$	0.90	$	0.24	$	1.73

Schedule of anti-dilutive securities

The following common stock equivalents were not included in the computation of diluted net income per share because their effect was anti-dilutive for the periods presented:

	Three Months Ended June 30,				Six Months Ended June 30,
(In thousands)	2022		2021		2022		2021
Outstanding options and awards granted under equity incentive    plan and employee stock purchase plan		642		1,093		514		1,126

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Revenue Recognition and Collaborative Arrangements (Tables)

6 Months Ended

Jun. 30, 2022

Revenue from Contract with Customer [Abstract]

Schedule of net revenue from collaborative arrangements

Net revenue recognized under our GSK Agreements was as follows:

	Three Months Ended June 30,						Six Months Ended June 30,
(In thousands)	2022			2021			2022			2021
Royalties from a related party    - RELVAR/BREO	$	59,326		$	65,916		$	115,090		$	122,306
Royalties from a related party    - ANORO		9,630			11,960			18,072			22,460
Royalties from a related party    - TRELEGY		42,720			26,386			72,029			48,470
Total royalties from a related party		111,676			104,262			205,191			193,236
Less: amortization of capitalized fees    paid to a related party		(3,456	)		(3,456	)		(6,912	)		(6,912	)
Royalty revenue from GSK	$	108,220		$	100,806		$	198,279		$	186,324

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Consolidated Entities (Tables)

6 Months Ended

Jun. 30, 2022

Theravance Respiratory Company, LLC

Consolidated Entities

Schedule of Balance Sheets and Income Statements of VIE

The summarized financial information for TRC is presented as follows:

Balance sheets

	June 30,		December 31,
(In thousands)	2022		2021
Assets
Cash and cash equivalents	$	89,806	$	50,713
Receivables from collaborative arrangements		42,720		42,492
Prepaid expenses and other current assets		85		71
Equity and long-term investments		42,536		37,695
Total assets	$	175,147	$	130,971
Liabilities and LLC Members’ Equity
Current liabilities	$	493	$	252
LLC members’ equity		174,654		130,719
Total liabilities and LLC members’ equity	$	175,147	$	130,971

Income statements

	Three Months Ended June 30,						Six Months Ended June 30,
(In thousands)	2022			2021			2022			2021
Royalty revenue from a related party	$	42,720		$	26,386		$	72,029		$	48,470
Operating expenses		139			336			337			3,617
Income from operations		42,581			26,050			71,692			44,853
Other income, net		10			—			10			—
Income tax expense, net		—			—			1			—
Changes in fair values of equity and long-term    investments		(9,313	)		(254	)		(8,884	)		(737	)
Net income	$	33,278		$	25,796		$	62,819		$	44,116

Entasis Therapeutics Holdings Inc

Consolidated Entities

Schedule of Recognized Identified Assets Acquired and Liabilities Assumed

The following table summarizes the preliminary allocation of the fair values assigned to the assets acquired and liabilities assumed as of the date of the consolidation:

(In thousands)	February 17, 2022
Cash and cash equivalents	$	23,070
Prepaid expenses		5,554
Other current assets		1,959
Property and equipment, net		185
Right-of-use assets		527
Goodwill		5,544
Intangible assets		105,000
Other assets		302
Total assets acquired	$	142,141
Accounts payable	$	1,583
Accrued personnel-related expenses		1,057
Other current liabilities		5,096
Total liabilities assumed	$	7,736
Total assets acquired, net	$	134,405

Schedule of Balance Sheet Information

The following table provides the assets and liabilities of Entasis:

(In thousands)	June 30, 2022
Assets
Current assets:
Cash and cash equivalents	$	22,408
Prepaid expenses		3,177
Other current assets		1,035
Total current assets		26,620
Property and equipment, net		171
Right-of-use assets		3,503
Goodwill		5,544
Intangible assets		105,000
Other assets		1,147
Total assets	$	141,985
Liabilities
Current liabilities:
Accounts payable	$	4,025
Accrued personnel-related expenses		3,385
Other accrued liabilities		8,195
Total current liabilities		15,605
Lease liabilities, long-term		3,091
Total liabilities	$	18,696

Pro Forma Information

	Three Months Ended June 30,					Six Months Ended June 30,
(In thousands)	2022			2021		2022		2021
Revenue	$	108,220		$	100,806	$	198,279	$	186,324
Net income	$	17,221		$	34,140	$	55,248	$	144,490
Net income attributable to Innoviva stockholders	$	(3,306	)	$	17,063	$	15,727	$	116,130

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Financial Instruments and Fair Value Measurements (Tables)

6 Months Ended

Jun. 30, 2022

Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]

Schedule of Available-for-Sale Securities Measured at Fair Value on a Recurring Basis

Our equity and long-term investments are measured at fair value on a recurring basis and our debt is carried at amortized cost basis. Equity investments accounted for using the measurement alternative are valued using Level 3 inputs.

	Estimated Fair Value Measurements as of June 30, 2022 Using:
	Quoted Price in Active Markets for		Significant Other		Significant
	Identical		Observable		Unobservable
Types of Instruments	Assets		Inputs		Inputs
(In thousands)	Level 1		Level 2		Level 3		Total
Assets
Money market funds	$	156,460	$	—	$	—	$	156,460
Investments held by ISP Fund LP (1)		304,810		—		2,053		306,863
Equity investment - Armata Common Stock		97,549		—		—		97,549
Equity investment - Armata Warrants		—		47,148		—		47,148
Equity investment - InCarda Series C Preferred Stock						6,808		6,808
Equity investment - InCarda Preferred Stock Warrants						342		342
Convertible debt investment - Gate Note		—		—		15,200		15,200
Total assets measured at estimated fair value	$	558,819	$	47,148	$	24,403	$	630,370
Debt
2023 Notes	$	—	$	95,606	$	—	$	95,606
2025 Notes		—		214,443		—		214,443
2028 Notes		—		225,530		—		225,530
Total fair value of debt	$	—	$	535,579	$	—	$	535,579

(1)The investments held by ISP Fund LP, consisted of $201.6 million in equity investments, which included a private placement position of $2.1 million, $35.3 million in money market funds and $70.0 million in cash. Our total capital contribution of $300.0 million is subject to a 36-month lock-up period from the date of such capital contributions.

	Estimated Fair Value Measurements as of December 31, 2021 Using:
	Quoted Price
	in Active		Significant
	Markets for		Other		Significant
	Identical		Observable		Unobservable
Types of Instruments	Assets		Inputs		Inputs
(In thousands)	Level 1		Level 2		Level 3		Total
Assets
Money market funds	$	145,132	$	—	$	—	$	145,132
Investments held by ISP Fund LP (1)		193,677		—		2,068		195,745
Equity investment - Armata Common Stock		88,101		—		—		88,101
Equity investment - Armata Warrants		—		58,595		—		58,595
Equity investment - Entasis Common Stock		62,794		—		—		62,794
Equity investment - Entasis Warrants		—		40,914		—		40,914
Equity investment - InCarda Warrants		—		—		411		411
Convertible debt investment - Gate Note		—		—		15,100		15,100
Total assets measured at estimated fair value	$	489,704	$	99,509	$	17,579	$	606,792
Debt
2023 Notes	$	—	$	261,769	$	—	$	261,769
2025 Notes		—		234,498		—		234,498
Total fair value of debt	$	—	$	496,267	$	—	$	496,267

(1)The investments held by ISP Fund LP, consisted of $192.2 million equity investments and $3.5 million money market funds, are subject to a 36-month lock-up period from our initial contribution date, December 11, 2020.

Armata

Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]

Schedule of Income Statement Information

The summarized financial information, including the portion we do not own, is presented for Armata on a one quarter lag regardless of the date of our investments as follows:

Income Statement Information

	Three Months Ended March 31,						Six Months Ended March 31,
(In thousands)	2022			2021			2022			2021
Revenue	$	1,236		$	1,066		$	2,225		$	1,570
Loss from operations	$	(8,775	)	$	(5,435	)	$	(14,823	)	$	(11,888	)
Net loss	$	(8,774	)	$	(5,495	)	$	(14,821	)	$	(12,119	)

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Goodwill and Intangible Assets (Tables)

6 Months Ended

Jun. 30, 2022

Goodwill and Intangible Assets Disclosure [Abstract]

Summary of Accumulated Amortization of Recognized Intangible Assets

The carrying basis and accumulated amortization of recognized intangible assets as of June 30, 2022 were as follows:

	Carrying
(In thousands)	Amount
Intangible assets with indefinite life	$	69,500
Intangible asset with determinable life		35,500
Total	$	105,000

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Balance Sheet Components (Tables)

6 Months Ended

Jun. 30, 2022

Balance Sheet Related Disclosures [Abstract]

Schedule Of Other Accrued Liabilities

Other accrued liabilities consisted of the following:

	June 30,		December 31,
(in thousands)	2022		2021
Accrued contract manufacturing	$	4,621	$	—
Accrued clinical		994		—
Accrued research		330		—
Accrued professional services		3,829		894
Current portion of lease liabilities		687		106
Liabilities for unsettled security transactions		6,328		—
Other		355		9
Total other accrued liabilities	$	17,144	$	1,009

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Stock-Based Compensation (Tables)

6 Months Ended

Jun. 30, 2022

Share-Based Payment Arrangement [Abstract]

Schedule of stock-based compensation expense

The following table summarizes stock-based compensation expense, which included $0.7 million and $1.0 million, respectively, related to Entasis’ equity awards, for the three and six months ended June 30, 2022:

	Three Months Ended June 30,				Six Months Ended June 30,
(In thousands)	2022		2021		2022		2021
General and administrative	$	1,030	$	470	$	1,818	$	921
Research and development		320		—		486		—
Total	$	1,350	$	470	$	2,304	$	921

Summary of weighted-average assumptions used to calculate estimated value of stock options

Black-Scholes-Merton assumptions used in calculating the estimated value of stock options granted by Innoviva on the date of grant were as follows:

	Three Months Ended June 30,						Six Months Ended June 30,
	2022			2021			2022			2021
Risk-free interest rate	2.84% - 3.03%			1.07%			1.6% - 3.03%			1.07% - 1.13%
Expected term (in years)	5.50 - 6.11				6.00		5.50 - 6.11				6.00
Volatility	38.8% - 39.0%				45.0	%	38.8% - 40.5%				45.0	%
Dividend yield		0.0	%		0.0	%		0.0	%		0.0	%
Weighted-average estimated fair value of stock options granted	$6.98 - $7.18			$	5.80		$6.98 - $7.73			$	5.61

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Debt (Tables)

6 Months Ended

Jun. 30, 2022

Debt

Schedule of debt

Our debt consisted of the following:

	June 30,			December 31,
(In thousands)	2022			2021
2023 Notes	$	96,204		$	240,984
2025 Notes		192,500			192,500
2028 Notes		261,000			—
Total debt		549,704			433,484
Less: Unamortized debt discount and issuance costs		(10,454	)		(38,831	)
Total debt, net	$	539,250		$	394,653
Less: Current portion of long-term debt, net		96,072			—
Total long-term debt, net	$	443,178		$	394,653

Aggregate scheduled maturities of convertible debt

The aggregate scheduled maturities of our convertible debt as of June 30, 2022 were as follows:

(In thousands)	June 30, 2022
Years ending December 31:
Remainder of 2022	$	—
2023		96,204
2024		—
2025		192,500
2026		—
Thereafter		261,000
Total	$	549,704

2023 Notes

Debt

Summary of liability and equity components of convertible notes

Our outstanding 2023 Notes balances consisted of the following:

	June 30,			December 31,
(In thousands)	2022			2021
Liability component
Principal	$	96,204		$	240,984
Debt issuance costs, net		(132	)		(620	)
Net carrying amount	$	96,072		$	240,364

Schedule of components of interest expense

The following table sets forth total interest expense recognized related to the 2023 Notes for the three and six months ended June 30, 2022 and 2021:

	Three Months Ended June 30,				Six Months Ended June 30,
(In thousands)	2022		2021		2022		2021
Contractual interest expense	$	511	$	1,280	$	1,595	$	2,560
Amortization of debt issuance costs		59		147		181		288
Total interest and amortization expense	$	570	$	1,427	$	1,776	$	2,848

2025 Notes

Debt

Summary of liability and equity components of convertible notes

Our outstanding 2025 Notes balances consisted of the following:

	June 30,			December 31,
(In thousands)	2022			2021
Liability component
Principal	$	192,500		$	192,500
Debt discount and issuance costs, net		(2,265	)		(38,211	)
Net carrying amount	$	190,235		$	154,289
Equity component, net	$	—		$	65,361

Schedule of components of interest expense

The following table sets forth total interest expense recognized related to the 2025 Notes for the three and six months ended June 30, 2022 and 2021:

	Three Months Ended June 30,				Six Months Ended June 30,
(In thousands)	2022		2021		2022		2021
Contractual interest expense	$	1,203	$	1,203	$	2,406	$	2,406
Amortization of debt issuance costs		172		162		343		321
Amortization of debt discount		—		1,951		—		3,862
Total interest and amortization expense	$	1,375	$	3,316	$	2,749	$	6,589

2028 Notes

Debt

Summary of liability and equity components of convertible notes

Our outstanding 2028 Notes balance as of June 30, 2022 consisted of the following:

(In thousands)	June 30, 2022
Liability component
Principal	$	261,000
Debt issuance costs, net		(8,057	)
Net carrying amount	$	252,943

Schedule of components of interest expense

The following table sets forth total interest expense recognized related to the 2028 Notes from the date of issuance through June 30, 2022:

	Three Months Ended June 30,		Six Months Ended June 30,
(In thousands)	2022		2022
Contractual interest expense	$	1,387	$	1,756
Amortization of debt issuance costs		323		407
Total interest and amortization expense	$	1,710	$	2,163

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Commitments and Contingencies (Tables)

6 Months Ended

Jun. 30, 2022

Lessee, Lease, Description [Line Items]

Schedule of Operating Lease Information Presented In Balance Sheet

The following table summarizes our operating leases as presented in the unaudited condensed consolidated balance sheets:

	June 30,		December 31,
(In thousands)	2022		2021
Assets
Right-of-use assets	$	3,545	$	97
Liabilities
Lease liabilities, current	$	687	$	106
Lease liabilities, long-term		3,091		—
Total lease liabilities	$	3,778	$	106

EntasisLease

Lessee, Lease, Description [Line Items]

Schedule of Future Minimum Lease Payments

Future minimum operating lease payments on the Entasis Lease as of June 30, 2022 were as follows:

(In thousands)	June 30, 2022
Years ending December 31:
Remainder of 2022	$	368
2023		1,249
2024		1,269
2025		1,289
Total undiscounted lease payments		4,175
Less: imputed interest		(442	)
Total operating lease liabilities	$	3,733

Burlingame, California

Lessee, Lease, Description [Line Items]

Schedule of Future Minimum Lease Payments

Future minimum operating lease payments on our corporate headquarters in Burlingame, California as of June 30, 2022 were as follows:

(In thousands)	June 30, 2022
Years ending December 31:
Remainder of 2022	$	46
Thereafter		—
Total	$	46

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Description of Operations and Summary of Significant Accounting Policies (Details) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Dec. 31, 2021
Description of Operations and Summary of Significant Accounting Policies
Decrease to accumulated deficit	$ 37,200
Reduction to Additional Paid in Capital	65,400
Equity and long-term investments	494,097		$ 483,845
Purchases of equity investments managed by ISP Fund LP	(38,026)	$ (142,636)
Sale of equity investments managed by ISP Fund LP	24,281	18,545
Purchase and sales of other investments managed by ISP Fund LP, net	96,255	(234,091)
Increase in Deferred Tax Assets	7,400
Prior Period Immaterial Correction
Description of Operations and Summary of Significant Accounting Policies
Purchases of equity investments managed by ISP Fund LP		(142,600)
Sale of equity investments managed by ISP Fund LP		18,500
Purchase and sales of other investments managed by ISP Fund LP, net		$ 234,100
Convertible senior notes
Description of Operations and Summary of Significant Accounting Policies
Increase in convertible notes	$ 35,600
Long-Acting Beta2 Agonist (LABA) Collaboration | GSK
Description of Operations and Summary of Significant Accounting Policies
Percentage of economic interest in any future payments made under the agreements	15.00%
Long-Acting Beta2 Agonist (LABA) Collaboration | GSK | RELVAR/BREO
Description of Operations and Summary of Significant Accounting Policies
Royalty rate for first level of annual global net sales (as a percent)	15.00%
Annual global sales level used to determine royalty rate	$ 3,000,000
Royalty rate for sales above first level of annual global net sales (as a percent)	5.00%
Long-Acting Beta2 Agonist (LABA) Collaboration | GSK | ANORO | Minimum
Description of Operations and Summary of Significant Accounting Policies
Royalty rate for combination products (as a percent)	6.50%
Long-Acting Beta2 Agonist (LABA) Collaboration | GSK | ANORO | Maximum
Description of Operations and Summary of Significant Accounting Policies
Royalty rate for combination products (as a percent)	10.00%

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Net Income Per Share (Details) - 2025 Notes - Convertible senior notes - $ / shares	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021	Aug. 07, 2017
Debt Instrument [Line Items]
Dilutive effect of the assumed conversion premium		0		0
Dilutive EPS of note	$ 0.01		$ 0.03
Common Stock [Member]
Debt Instrument [Line Items]
Conversion price (dollars per share)		$ 17.26		$ 17.26	$ 17.26

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Net Income Per Share - Basic and Diluted EPS (Details) - USD ($) $ / shares in Units, shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Numerator:
Net income attributable to Innoviva stockholders, basic	$ 939	$ 88,948	$ 16,712	$ 183,071
Net income attributable to Innoviva stockholders, diluted	$ 4,593	$ 90,111	$ 22,935	$ 185,438
Denominator:
Weighted-average shares used to compute basic net income per share attributable to Innoviva stockholders	69,643	88,423	69,594	94,858
Dilutive effect of options and awards granted under equity incentive plan and employee stock purchase plan	39	27	77	49
Weighted-average shares used to compute diluted net income per share attributable to Innoviva stockholders	95,653	100,639	94,692	107,096
Net income per share attributable to Innoviva stockholders
Basic net income per share	$ 0.01	$ 1.01	$ 0.24	$ 1.93
Diluted net income per share	$ 0.05	$ 0.90	$ 0.24	$ 1.73
2023 Notes
Numerator:
Add: interest expense on Notes	$ 570	$ 1,163	$ 1,591	$ 2,367
Denominator:
Dilutive effect	4,866	12,189	7,511	12,189
2025 Notes
Numerator:
Add: interest expense on Notes	$ 1,375	$ 0	$ 2,539	$ 0
Denominator:
Dilutive effect	11,150	0	11,150	0
2028 Notes
Numerator:
Add: interest expense on Notes	$ 1,709	$ 0	$ 2,093	$ 0
Denominator:
Dilutive effect	9,955	0	6,360	0

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Net Income Per Share - Anti-Dilutive Securities (Details) - shares shares in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Equity incentive plans and ESPP
Anti-Dilutive Securities
Anti-dilutive securities (in shares)	642	1,093	514	1,126

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Revenue Recognition and Collaborative Arrangements (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Revenue Recognition and Collaborative Arrangements
Net revenue	$ 108,220	$ 100,806	$ 198,279	$ 186,324
GSK | Royalty revenue from a related party
Revenue Recognition and Collaborative Arrangements
Royalties from a related party	111,676	104,262	205,191	193,236
Less: amortization of capitalized fees paid to a related party	(3,456)	(3,456)	(6,912)	(6,912)
Net revenue	108,220	100,806	198,279	186,324
GSK | RELVAR/BREO
Revenue Recognition and Collaborative Arrangements
Royalties from a related party	59,326	65,916	115,090	122,306
GSK | ANORO
Revenue Recognition and Collaborative Arrangements
Royalties from a related party	9,630	11,960	18,072	22,460
GSK | TRELEGY
Revenue Recognition and Collaborative Arrangements
Royalties from a related party	$ 42,720	$ 26,386	$ 72,029	$ 48,470

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Consolidated Entities - Theravance Respiratory Company, LLC (Details) - USD ($) $ in Thousands	3 Months Ended				6 Months Ended		12 Months Ended
	Jun. 30, 2022	Mar. 31, 2022	Jun. 30, 2021	Mar. 31, 2021	Jun. 30, 2022	Jun. 30, 2021	Dec. 31, 2021
Assets
Cash and cash equivalents	$ 283,580				$ 283,580		$ 201,525
Receivables from collaborative arrangements	111,676				111,676		110,711
Prepaid expenses	3,953				3,953		1,367
Equity and long-term investments	494,097				494,097		483,845
Total assets	1,137,639				1,137,639		926,395
Liabilities and LLC Members' Equity
Current liabilities	125,908				125,908		5,807
Total liabilities and stockholders' equity	1,137,639				1,137,639		$ 926,395
Income statements
Total revenue	108,220		$ 100,806		198,279	$ 186,324
Operating expenses	25,666		4,266		37,996	10,301
Income from operations	82,554		96,540		160,283	176,023
Other income, net	(528)		(951)		(778)	(1,384)
Income tax expense (benefit), net	(876)		25,333		5,984	45,069
Changes in fair values of equity and long-term investments	(58,600)		45,315		(68,011)	100,360
Net income	21,371	$ 37,858	110,846	$ 109,695	$ 59,229	220,541
Theravance Respiratory Company, LLC
CONSOLIDATED ENTITIES
Economic interest in LLC (in percent)					15.00%		15.00%
Assets
Cash and cash equivalents	89,806				$ 89,806		$ 50,713
Receivables from collaborative arrangements	42,720				42,720		42,492
Prepaid expenses	85				85		71
Equity and long-term investments	42,536				42,536		37,695
Total assets	175,147				175,147		130,971
Liabilities and LLC Members' Equity
Current liabilities	493				493		252
LLC members' equity	174,654				174,654		130,719
Total liabilities and stockholders' equity	175,147				175,147		$ 130,971
Income statements
Operating expenses	139		336		337	3,617
Income from operations	42,581		26,050		71,692	44,853
Other income, net	10		0		10	0
Income tax expense (benefit), net	0		0		1	0
Changes in fair values of equity and long-term investments	(9,313)		(254)		(8,884)	(737)
Net income	33,278		25,796		62,819	44,116
Theravance Respiratory Company, LLC | Royalty revenue from a related party
Income statements
Total revenue	$ 42,720		$ 26,386		$ 72,029	$ 48,470

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Consolidated Entities - Entasis Therapeutics Holdings, Inc. (Details) $ / shares in Units, $ in Thousands		3 Months Ended				6 Months Ended
	Feb. 17, 2022 USD ($) $ / shares	Jun. 30, 2022 USD ($)	Jun. 30, 2021 USD ($) $ / shares shares	Sep. 30, 2020 USD ($) $ / shares shares	Jun. 30, 2020 USD ($) $ / shares shares	Jun. 30, 2022 USD ($) Director	Jun. 30, 2021 USD ($) $ / shares	Dec. 31, 2021 USD ($)
Subsidiary or Equity Method Investee [Line Items]
Total debt		$ 549,704				$ 549,704		$ 433,484
Noncontrolling interest		177,125				177,125		$ 111,192
Net income attributable to noncontrolling interest		20,432	$ 21,898			42,517	$ 37,470
Remeasurement loss						7,700
Net loss attributable to Innoviva stockholders		939	88,948			$ 16,712	183,071
Entasis Therapeutics Holdings Inc
Subsidiary or Equity Method Investee [Line Items]
Number of investee's board members which may be designated by the Company | Director						2
Noncontrolling interest	$ 38,500
Increase/Decrease in fair value related to equity method investments			$ 64,700			$ (7,800)	53,200
Decrease for acquisition related costs							$ 100
Increase for acquisition related costs						100
Equity investment ownership percentage	59.90%
Net loss attributable to Innoviva stockholders		$ 11,700				$ 16,300
Entasis Therapeutics Holdings Inc | Securities Purchase Agreement | Convertible Promissory Note
Subsidiary or Equity Method Investee [Line Items]
Total debt	$ 15,000
Debt instrument maturity date	Aug. 18, 2022
Debt Instrument, annual interest rate	0.59%
Conversion price (dollars per share) | $ / shares	$ 1.48
Entasis Therapeutics Holdings Inc | Common stock
Subsidiary or Equity Method Investee [Line Items]
Number of shares to be purchased under the securities purchase agreement | shares				4,672,897	14,000,000
Fair value of equity securities	$ 64,500
Entasis Therapeutics Holdings Inc | Common stock | Innoviva Strategic Opportunities, LLC
Subsidiary or Equity Method Investee [Line Items]
Number of shares to be purchased under the securities purchase agreement | shares			10,000,000
Entasis Therapeutics Holdings Inc | Warrants
Subsidiary or Equity Method Investee [Line Items]
Number of warrants purchased under the securities purchase agreement | shares				4,672,897	14,000,000
Fair value of equity securities	$ 31,400
Entasis Therapeutics Holdings Inc | Warrants | Innoviva Strategic Opportunities, LLC
Subsidiary or Equity Method Investee [Line Items]
Number of shares to be purchased under the securities purchase agreement | shares			10,000,000
Entasis Therapeutics Holdings Inc | Common stock and warrants
Subsidiary or Equity Method Investee [Line Items]
Payments to acquire equity securities				$ 12,500	$ 35,000
Entasis Therapeutics Holdings Inc | Common stock and warrants | Innoviva Strategic Opportunities, LLC
Subsidiary or Equity Method Investee [Line Items]
Payments to acquire equity securities			$ 20,000
Entasis Therapeutics Holdings Inc | Warrants acquired in second quarter of 2021
Subsidiary or Equity Method Investee [Line Items]
Exercise price of warrants | $ / shares			$ 2.00				$ 2.00
Term of warrants		5 years				5 years
Entasis Therapeutics Holdings Inc | Warrants acquired in third quarter of 2020
Subsidiary or Equity Method Investee [Line Items]
Exercise price of warrants | $ / shares				$ 2.675
Term of warrants		5 years				5 years
Entasis Therapeutics Holdings Inc | Warrants acquired in second quarter of 2020
Subsidiary or Equity Method Investee [Line Items]
Exercise price of warrants | $ / shares					$ 2.50
Term of warrants		5 years				5 years

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Consolidated Entities - Schedule of Recognized Identified Assets Acquired and Liabilities Assumed (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Feb. 17, 2022	Dec. 31, 2021
Business Acquisition [Line Items]
Goodwill	$ 5,544		$ 0
Entasis Therapeutics Holdings Inc [Member]
Business Acquisition [Line Items]
Cash and cash equivalents		$ 23,070
Prepaid expenses		5,554
Other current assets		1,959
Property and equipment, net		185
Right of use assets		527
Goodwill	$ 5,544	5,544
Intangible assets		105,000
Other assets		302
Total assets acquired		142,141
Accounts payable		1,583
Accrued personnel-related expenses		1,057
Other current liabilities		5,096
Total liabilities assumed		7,736
Total assets acquired, net		$ 134,405

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Consolidated Entities - Schedule of Assets and Liabilities of Entasis (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Feb. 17, 2022	Dec. 31, 2021
Current assets:
Other current assets	$ 1,119		$ 70
Total current assets	400,328		313,673
Property and equipment, net	176		12
Right-of-use assets	3,545		97
Goodwill	5,544		0
Intangible assets	105,000		0
Other assets	1,157		11
Total assets	1,137,639		926,395
Current liabilities:
Accounts payable	4,323		27
Accrued personnel-related expenses	3,871		619
Total current liabilities	125,908		5,807
Lease Liabilities, long-term	3,091		$ 0
Entasis Therapeutics Holdings Inc [Member]
Current assets:
Cash and cash equivalents	22,408
Prepaid expenses	3,177
Other current assets	1,035
Total current assets	26,620
Property and equipment, net	171
Right-of-use assets	3,503
Goodwill	5,544	$ 5,544
Intangible assets	105,000
Other assets	1,147
Total assets	141,985
Current liabilities:
Accounts payable	4,025
Accrued personnel-related expenses	3,385
Other accrued liabilities	8,195
Total current liabilities	15,605
Lease Liabilities, long-term	3,091
Liabilities, Total	$ 18,696

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Consolidated Entities - Pro Forma Information (Details) - Entasis Therapeutics Holdings Inc - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Business Acquisition [Line Items]
Revenue	$ 108,220	$ 100,806	$ 198,279	$ 186,324
Net income	17,221	34,140	55,248	144,490
Net income attributable to Innoviva stockholders	$ (3,306)	$ 17,063	$ 15,727	$ 116,130

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Consolidated Entities - ISP Fund LP (Details) - USD ($) $ in Thousands		3 Months Ended		6 Months Ended
	Mar. 30, 2022	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021	Dec. 31, 2021	May 31, 2021	Dec. 31, 2020
CONSOLIDATED ENTITIES
Total assets		$ 1,137,639		$ 1,137,639		$ 926,395
Changes in fair values of equity and long-term investments		(58,600)	$ 45,315	$ (68,011)	$ 100,360
ISP Fund LP
CONSOLIDATED ENTITIES
Contributed to partnership for investing								$ 300,000
Distribution from partnership							$ 110,000
Economic interest of the Partnership (in percent)				100.00%
Total assets		306,900		$ 306,900		195,800
Total liabilities		6,400		6,400		$ 200
Investment-related expenses, net of investment-related income		500	900	700	1,300
Changes in fair values of equity and long-term investments		$ (6,500)	$ 25,200	$ (4,400)	$ 31,000
Commitment for future contribution	$ 110,000
Lock-up period	36 months

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Financial Instruments and Fair Value Measurements - Equity Investment in Armata (Details) - Armata $ / shares in Units, $ in Millions		3 Months Ended					6 Months Ended
	Feb. 09, 2022 USD ($) $ / shares shares	Jun. 30, 2022 USD ($) Director $ / shares	Dec. 31, 2021 USD ($) shares	Jun. 30, 2021 USD ($)	Mar. 31, 2021 USD ($) $ / shares shares	Mar. 31, 2020 USD ($) $ / shares shares	Jun. 30, 2022 USD ($) Tranche Director $ / shares	Jun. 30, 2021 USD ($)
Equity investment
Number of tranches | Tranche							2
Equity investment ownership percentage		69.40%	59.30%				69.40%
Percentage of maximum voting rights	49.50%						49.50%
Number of Investee's Board members currently representing the Company | Director		3					3
Number of the Investee's Board members | Director		8					8
Unrealized gain from fair value changes in equity investments								$ 36.9
Unrealized loss from fair value changes in equity investments		$ 42.8		$ 24.3			$ 47.0
Two Directors
Equity investment
Armata outstanding shares percentage	12.50%
Common stock and warrants
Equity investment
Amount of securities purchase agreement						$ 25.0
Equity and long-term investments at fair value		$ 144.7	$ 146.7				$ 144.7
Warrants purchased in 2020
Equity investment
Exercise price of warrants | $ / shares						$ 2.87
Term of warrants		5 years					5 years
Warrants purchased in 2021
Equity investment
Exercise price of warrants | $ / shares					$ 3.25
Term of warrants		5 years					5 years
Warrants purchased in 2022 Member
Equity investment
Exercise price of warrants | $ / shares		$ 5.00					$ 5.00
Term of warrants		5 years					5 years
Warrants
Equity investment
Number of warrants purchased under the securities purchase agreement | shares						8,710,800
Equity and long-term investments at fair value		$ 47.1	$ 58.6				$ 47.1
Common stock
Equity investment
Number of shares to be purchased under the securities purchase agreement | shares						8,710,800
Number of shares to be purchased under the securities purchase agreement | shares			1,212,122
Amount of securities purchase agreement			$ 4.0
Equity and long-term investments at fair value		$ 97.6	$ 88.1				$ 97.6
Minimum [Member] | One Director
Equity investment
Armata outstanding shares percentage	8.00%
Maximum [Member] | One Director
Equity investment
Armata outstanding shares percentage	12.50%
Innoviva Strategic Opportunities, LLC | Common stock and warrants
Equity investment
Amount of securities purchase agreement	$ 45.0				$ 20.0
Innoviva Strategic Opportunities, LLC | Warrants
Equity investment
Number of warrants to be purchased under the securities purchase agreement | shares	4,500,000				6,153,847
Exercise price of warrants | $ / shares	$ 5.00
Innoviva Strategic Opportunities, LLC | Common stock
Equity investment
Number of shares to be purchased under the securities purchase agreement | shares	9,000,000				6,153,847

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Financial Instruments and Fair Value Measurements - Schedule of Income Statement Information (Details) - USD ($) $ in Thousands	3 Months Ended				6 Months Ended
	Jun. 30, 2022	Mar. 31, 2022	Jun. 30, 2021	Mar. 31, 2021	Jun. 30, 2022	Mar. 31, 2022	Jun. 30, 2021	Mar. 31, 2021
Equity Investment
Net revenue	$ 108,220		$ 100,806		$ 198,279		$ 186,324
Loss from operations	82,554		96,540		160,283		176,023
Net Income	$ 21,371	$ 37,858	$ 110,846	$ 109,695	$ 59,229		$ 220,541
Armata
Equity Investment
Net revenue		1,236		1,066		$ 2,225		$ 1,570
Loss from operations		(8,775)		(5,435)		(14,823)		(11,888)
Net Income		$ (8,774)		$ (5,495)		$ (14,821)		$ (12,119)

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Financial Instruments and Fair Value Measurements - Equity Investment in InCarda (Details)			3 Months Ended			6 Months Ended		12 Months Ended
	Jun. 15, 2022 USD ($) $ / shares shares	Mar. 09, 2022 USD ($)	Jun. 30, 2022 USD ($) Director $ / shares	Jun. 30, 2021 USD ($)	Sep. 30, 2020 USD ($) $ / shares shares	Jun. 30, 2022 USD ($) Director $ / shares	Jun. 30, 2021 USD ($)	Dec. 31, 2021 USD ($)
Equity Investment
Equity and long-term investments			$ 494,097,000			$ 494,097,000		$ 483,845,000
InCarda
Equity Investment
Number of Investee's Board members currently representing the Company | Director			1			1
Number of the Investee's Board members | Director			8			8
Equity investment ownership percentage			8.90%			8.90%		13.00%
Unrealized loss from fair value changes in equity investments				$ 300,000			$ 700,000
Unrealized loss from fair value changes in equity investments			$ 9,600,000			$ 9,000,000.0
InCarda | Series C preferred stock and warrants
Equity Investment
Amount of securities purchase agreement					$ 15,800,000
InCarda | Warrants
Equity Investment
Maximum number of additional shares into which warrants may be converted under the securities purchase agreement | shares					5,117,358
Equity and long-term investments at fair value								$ 400,000
Exercise price of warrants | $ / shares			$ 0.7328			$ 0.7328
Extended expiration date						Mar. 31, 2023
InCarda | Convertible note and warrants
Equity Investment
Amount of securities purchase agreement		$ 700,000
InCarda | Common stock
Equity Investment
Number of shares to be purchased under the securities purchase agreement | shares	4,093,886
InCarda | Series A1 preferred stock
Equity Investment
Debt Conversion, Converted Instrument, Shares Issued | shares	37,350
InCarda | Series D 1 Preferred Stock
Equity Investment
Number of shares to be purchased under the securities purchase agreement | shares	8,771,780
InCarda | Series D 2 Preferred Stock
Equity Investment
Debt Conversion, Converted Instrument, Shares Issued | shares	3,369,802
Exercise price of warrants | $ / shares	$ 0.26
InCarda | Series D2 Warrants
Equity Investment
Debt Conversion, Converted Instrument, Shares Issued | shares	2,490,033
InCarda | Series C preferred stock
Equity Investment
Number of shares to be purchased under the securities purchase agreement | shares					20,469,432
Number of warrants purchased under the securities purchase agreement | shares					5,117,358
Transaction cost					$ 800,000
Equity and long-term investments at fair value								15,800,000
Impairment of equity investments						$ 9,000,000.0		$ 0
Exercise price of warrants | $ / shares					$ 0.73
InCarda | Series C Preferred Stock and Series C and D Warrants
Equity Investment
Equity and long-term investments at fair value			$ 7,200,000			7,200,000
InCarda | Series D Preferred Stock
Equity Investment
Payments to acquire equity securities	$ 2,300,000
InCarda | Series D1 Preferred Stock, Series D2 Preferred Stock and Common Stock
Equity Investment
Equity and long-term investments at fair value			$ 3,200,000			$ 3,200,000
InCarda | Significant Unobservable Inputs, Level 3 | Backsolve Valuation
Equity Investment
Risk free interest rate						3.20%
Dividend yield						0.00%
Estimated volatility						122.00%
InCarda Convertible Note
Equity Investment
Debt Instrument, annual interest rate		6.00%
Gross Proceeds from sale of equity		$ 10,000,000.0
Debt instrument principal amount percentage						100.00%

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Financial Instruments and Fair Value Measurements - Equity Investment in ImaginAb (Details) $ in Thousands	3 Months Ended
	Mar. 31, 2021 USD ($) shares	Jun. 30, 2022 USD ($) Director	Dec. 31, 2021 USD ($)
Equity Investment
Equity and long-term investments		$ 494,097	$ 483,845
ImaginAb
Equity Investment
Transaction costs to acquire equity securities	$ 400
Equity investment ownership percentage		14.40%	14.50%
Number of Investee's Board members currently representing the Company | Director		1
Number of the Investee's Board members | Director		5
Equity and long-term investments at fair value		$ 6,400	$ 6,400
ImaginAb | Series C preferred stock
Equity Investment
Number of shares to be purchased under the securities purchase agreement | shares	4,051,724
Amount of securities purchase agreement	$ 4,700
ImaginAb | One of ImaginAb's Common Stockholders | Common stock
Equity Investment
Number of shares to be purchased under the securities purchase agreement | shares	4,097,157
Amount of securities purchase agreement	$ 1,300

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Financial Instruments and Fair Value Measurements - Convertible Promissory Note in Gate Neuroscience (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Dec. 31, 2021	Jun. 30, 2022
Equity Investment
Equity and long-term investments	$ 494,097	$ 483,845	$ 494,097
Gate Neuroscience Member
Equity Investment
Number Of Common Stock Issued Description		The number of common stock shares to be issued in a qualified event shall be equal to the amount due on the conversion date divided by the lesser of a capped conversion price (the “Capped Conversion Price”) and the qualified event price (the “Qualified Event Price”). The Capped Conversion Price is calculated as $50.0 million divided by the number of shares of common stock outstanding at such time on a fully diluted basis. The Qualified Event Price is the price per share determined by the qualified event. A qualified financing is a sale or series of sales of preferred stock where (i) at least 50 percent of counterparties are not existing shareholders, (ii) net proceeds to Gate are at least $35.0 million, and (iii) the stated or implied equity valuation of Gate is at least $80.0 million. Shadow Preferred means preferred stock having identical rights, preferences and restrictions as the preferred stock that would be issued in a qualified financing.
Equity and long-term investments	15,200	$ 15,100	15,200
Unrealized gain from fair value changes in equity investments	$ 300		$ 100
Convertible Promissory Note Purchase Agreement | Gate Neuroscience Member
Equity Investment
Convertable notes Face Value		$ 15,000
Debt Instrument, Interest Rate, Effective Percentage		8.00%

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Financial Instruments and Fair Value Measurements - Equity Investment in Nanolive (Details) - Nanolive SFr in Millions, $ in Millions	Feb. 18, 2022 USD ($) shares	Feb. 18, 2022 CHF (SFr) shares	Jun. 30, 2022 USD ($) Director
Equity Investment
Transaction costs to acquire equity securities | $	$ 0.7
Number of the Investee's Board members | Director			7
Number of Investee's Board members currently representing the Company | Director			0
Equity investment ownership percentage			16.10%
Fair value of equity securities | $			$ 10.6
Series C preferred stock
Equity Investment
Number of shares to be purchased under the securities purchase agreement | shares	18,750,000	18,750,000
Amount of securities purchase agreement	$ 9.8	SFr 9.0

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Financial Instruments and Fair Value Measurements - Schedule of Available-for-Sale Securities Measured at Fair Value on a Recurring Basis (Details) - USD ($) $ in Thousands	6 Months Ended		12 Months Ended
	Jun. 30, 2022		Dec. 31, 2021
ISP Fund LP
Assets
Lock-up period	36 months		36 months
Contributed to partnership for investing	$ 300,000
Cash | ISP Fund LP
Assets
Total assets measured at estimated fair value	70,000
Money market funds | ISP Fund LP
Assets
Total assets measured at estimated fair value	35,300		$ 3,500
Equity investment | ISP Fund LP
Assets
Total assets measured at estimated fair value	201,600		192,200
Private Placement Positions | ISP Fund LP
Assets
Total assets measured at estimated fair value	2,100
Recurring basis
Assets
Total assets measured at estimated fair value	630,370		606,792
Recurring basis | Money market funds
Assets
Total assets measured at estimated fair value	156,460		145,132
Recurring basis | Equity investments and money market funds | ISP Fund LP
Assets
Total assets measured at estimated fair value	306,863	[1]	195,745	[2]
Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1
Assets
Total assets measured at estimated fair value	558,819		489,704
Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Money market funds
Assets
Total assets measured at estimated fair value	156,460		145,132
Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Equity investments and money market funds | ISP Fund LP
Assets
Total assets measured at estimated fair value	304,810	[1]	193,677	[2]
Recurring basis | Significant Other Observable Inputs, Level 2
Assets
Total assets measured at estimated fair value	47,148		99,509
Recurring basis | Significant Unobservable Inputs, Level 3
Assets
Total assets measured at estimated fair value	24,403		17,579
Recurring basis | Significant Unobservable Inputs, Level 3 | Equity investments and money market funds | ISP Fund LP
Assets
Total assets measured at estimated fair value	2,053	[1]	2,068	[2]
Nonrecurring basis | Debt
Fair Value Measurements
2023 Notes	95,606		261,769
2025 Notes	214,443		234,498
2028 Notes	225,530
Total fair value of debt	535,579		496,267
Nonrecurring basis | Significant Other Observable Inputs, Level 2 | Debt
Fair Value Measurements
2023 Notes	95,606		261,769
2025 Notes	214,443		234,498
2028 Notes	225,530
Total fair value of debt	535,579		496,267
Armata | Recurring basis | Equity investment | Common stock
Assets
Total assets measured at estimated fair value	97,549		88,101
Armata | Recurring basis | Equity investment | Warrants
Assets
Total assets measured at estimated fair value	47,148		58,595
Armata | Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Equity investment | Common stock
Assets
Total assets measured at estimated fair value	97,549		88,101
Armata | Recurring basis | Significant Other Observable Inputs, Level 2 | Equity investment | Warrants
Assets
Total assets measured at estimated fair value	47,148		58,595
Entasis Therapeutics Holdings Inc | Recurring basis | Equity investment | Common stock
Assets
Total assets measured at estimated fair value			62,794
Entasis Therapeutics Holdings Inc | Recurring basis | Equity investment | Warrants
Assets
Total assets measured at estimated fair value			40,914
Entasis Therapeutics Holdings Inc | Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Equity investment | Common stock
Assets
Total assets measured at estimated fair value			62,794
Entasis Therapeutics Holdings Inc | Recurring basis | Significant Other Observable Inputs, Level 2 | Equity investment | Warrants
Assets
Total assets measured at estimated fair value			40,914
InCarda | Recurring basis | Equity investment | Warrants
Assets
Total assets measured at estimated fair value			411
InCarda | Recurring basis | Equity investment | Series C preferred stock
Assets
Total assets measured at estimated fair value	6,808
InCarda | Recurring basis | Equity investment | Preferred Stock Warrants
Assets
Total assets measured at estimated fair value	342
InCarda | Recurring basis | Significant Unobservable Inputs, Level 3 | Equity investment | Warrants
Assets
Total assets measured at estimated fair value			411
InCarda | Recurring basis | Significant Unobservable Inputs, Level 3 | Equity investment | Series C preferred stock
Assets
Total assets measured at estimated fair value	6,808
InCarda | Recurring basis | Significant Unobservable Inputs, Level 3 | Equity investment | Preferred Stock Warrants
Assets
Total assets measured at estimated fair value	342
Gate Neuroscience Member | Recurring basis | Convertible Debt Member
Assets
Total assets measured at estimated fair value	15,200		15,100
Gate Neuroscience Member | Recurring basis | Significant Unobservable Inputs, Level 3 | Convertible Debt Member
Assets
Total assets measured at estimated fair value	$ 15,200		$ 15,100

[1] The investments held by ISP Fund LP, consisted of $201.6 million in equity investments, which included a private placement position of $2.1 million, $35.3 million in money market funds and $70.0 million in cash. Our total capital contribution of $300.0 million is subject to a 36-month lock-up period from the date of such capital contributions.

[2] The investments held by ISP Fund LP, consisted of $192.2 million equity investments and $3.5 million money market funds, are subject to a 36-month lock-up period from our initial contribution date, December 11, 2020.

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Goodwill and Intangible Assets (Additional Information) (Details) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Feb. 17, 2022	Dec. 31, 2021
Goodwill [Line Items]
Goodwill	$ 5,544		$ 0
Amortization expense	0
Entasis Therapeutics Holdings Inc
Goodwill [Line Items]
Goodwill	$ 5,544	$ 5,544

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Goodwill and Intangible Assets - Summary of Accumulated Amortization of Recognized Intangible Assets (Details) $ in Thousands	Jun. 30, 2022 USD ($)
Goodwill and Intangible Assets Disclosure [Abstract]
Intangible asset with indefinite life, net carrying amount	$ 69,500
Intangible asset with determinable life, net carrying amount	35,500
Net Carrying Amount	$ 105,000

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Balance Sheet Components - Schedule of Other Accrued Liabilities (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Balance Sheet Related Disclosures [Abstract]
Accrued contract manufacturing	$ 4,621	$ 0
Accrued clinical	994	0
Accrued research	330	0
Accrued professional services	3,829	894
Current portion of lease liabilities	687	106
Liabilities for unsettled security transactions	6,328	0
Other	355	9
Total other accrued liabilities	$ 17,144	$ 1,009

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Balance Sheet Components (Additional Information) (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Total other accrued liabilities	$ 17,144	$ 1,009
Entasis Therapeutics Holdings Inc [Member]
Total other accrued liabilities	$ 8,200

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Stock-Based Compensation (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Stock based compensation expense	$ 1,350	$ 470	$ 2,304	$ 921
Entasis Therapeutics Holdings Inc [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Stock based compensation expense	$ 700		$ 1,000

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Stock-Based Compensation - Stock-Based Compensation Expense (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Stock-based compensation
Total stock-based compensation expense	$ 1,350	$ 470	$ 2,304	$ 921
General and administrative
Stock-based compensation
Total stock-based compensation expense	1,030	470	1,818	921
Research and development
Stock-based compensation
Total stock-based compensation expense	$ 320	$ 0	$ 486	$ 0

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Stock-Based Compensation - Valuation Assumptions (Details) - Stock options - Innoviva [Member] - $ / shares	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Weighted-average
Valuation Assumptions
Risk-free interest rate		1.07%
Expected term (in years)		6 years		6 years
Volatility		45.00%		45.00%
Dividend yield	0.00%	0.00%	0.00%	0.00%
Weighted-average estimated fair value of stock options granted		$ 5.80		$ 5.61
Minimum
Valuation Assumptions
Risk-free interest rate	2.84%		1.60%	1.07%
Expected term (in years)	5 years 6 months		5 years 6 months
Volatility	38.80%		38.80%
Weighted-average estimated fair value of stock options granted	$ 6.98		$ 6.98
Maximum
Valuation Assumptions
Risk-free interest rate	3.03%		3.03%	1.13%
Expected term (in years)	6 years 1 month 9 days		6 years 1 month 9 days
Volatility	39.00%		40.50%
Weighted-average estimated fair value of stock options granted	$ 7.18		$ 7.73

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Debt - Summary (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Debt
Total debt	$ 549,704	$ 433,484
Less: Unamortized debt discount and issuance costs	(10,454)	(38,831)
Total debt, net	539,250	394,653
Less: Current portion of long-term debt, net	96,072	0
Total long-term debt, net	443,178	394,653
2023 Notes | Convertible subordinated notes
Debt
Total debt	96,204	240,984
2025 Notes | Convertible senior notes
Debt
Total debt	192,500	192,500
Less: Unamortized debt discount and issuance costs	(2,265)	(38,211)
2028 Notes | Convertible senior notes
Debt
Total debt	261,000	$ 0
Less: Unamortized debt discount and issuance costs	$ (8,057)

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Debt - Convertible Subordinated Notes (Details)				1 Months Ended		3 Months Ended			6 Months Ended
	Apr. 18, 2022 USD ($)	Mar. 07, 2022 USD ($)	Jul. 31, 2014 $ / shares $ / Item	Jul. 31, 2014 $ / shares $ / Item shares	Jan. 31, 2013 USD ($) Item $ / shares $ / Item shares	Jun. 30, 2022 USD ($)	Mar. 31, 2022 USD ($)	Jun. 30, 2021 USD ($)	Jun. 30, 2022 USD ($)	Jun. 30, 2021 USD ($)	Apr. 30, 2022 USD ($)	Dec. 31, 2021 USD ($)	Dec. 31, 2016 USD ($)
Debt
Payment for repurchase of debt instrument									$ 165,131,000	$ 0
Accrued interest payable						$ 4,498,000			4,498,000			$ 4,152,000
Loss on extinguishment of debt						0		$ 0	(20,662,000)	0
Liability component
Principal						549,704,000			549,704,000			433,484,000
Debt discount and issuance costs, net						(10,454,000)			$ (10,454,000)			(38,831,000)
Convertible subordinated notes | Privately-negotiated capped call option
Debt
Cap price for the underlying number of shares (in dollars per share) | $ / Item			27.04	27.04
2023 Notes | Convertible subordinated notes
Debt
Loan amount					$ 287,500,000
Debt instrument maturity date					Jan. 15, 2023
Proceeds from issuance of notes payable, net of debt issuance costs					$ 281,200,000
Debt Instrument, annual interest rate					2.125%
Initial conversion, shares per $1,000 principal amount | shares | shares					35.9903
Adjusted conversion, shares per $1,000 principal amount | shares				50.5818
Conversion price of convertible notes into common stock (in dollars per share) | $ / shares			$ 19.77	$ 19.77	$ 27.79
Ratio of repurchase price to the principal amount									100.00%
Portion of debt retired, face value		$ 144,800,000					$ 144,800,000						$ 14,100,000
Portion of debt retired, carrying value							144,500,000						$ 13,900,000
Payment for repurchase of debt instrument		$ 165,600,000					$ 165,600,000
Percentage of notes repurchased		60.00%
Accrued interest payable		$ 400,000
Unamortized debt issuance cost		300,000
Loss on extinguishment of debt		$ 20,700,000
Effective interest rate		2.37%
Liability component
Principal	$ 96,200,000	$ 96,200,000				96,204,000			$ 96,204,000			240,984,000
Debt discount and issuance costs, net						(132,000)			(132,000)		$ (200,000)	(620,000)
Net Carrying Amount						96,072,000			96,072,000			$ 240,364,000
Interest expense
Contractual interest expense						511,000		1,280,000	1,595,000	2,560,000
Amortization of debt issuance costs						59,000		147,000	181,000	288,000
Total interest and amortization expense						$ 570,000		$ 1,427,000	$ 1,776,000	$ 2,848,000
2023 Notes | Convertible subordinated notes | Privately-negotiated capped call option
Debt
Payments for capped call options					$ 36,800,000
Number of derivative instruments purchased | Item					2
Strike price for the underlying number of shares (in dollars per share) | $ / shares			$ 27.79	$ 19.77	$ 27.79
Cap price for the underlying number of shares (in dollars per share) | $ / Item			38.00	38.00	38.00
2023 Notes | Convertible subordinated notes | Stock prices below $27.79 per share | Minimum
Debt
Net shares settlement payable to the entity | shares					0
2023 Notes | Convertible subordinated notes | Stock prices above $38.00 per share | Maximum
Debt
Net shares settlement payable to the entity | shares					2,779,659
Innoviva's Common Stock | 2023 Notes | Convertible subordinated notes
Liability component
Notes converted into common stock, Amount	$ 3,000.0

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Debt - Convertible Senior Notes (Details) $ / shares in Units, $ in Thousands		1 Months Ended	3 Months Ended			6 Months Ended		12 Months Ended
	Aug. 07, 2017 USD ($) $ / shares	Jan. 31, 2013 USD ($) $ / shares $ / Item	Jun. 30, 2022 USD ($)	Mar. 31, 2022 USD ($) $ / shares $ / Item	Jun. 30, 2021 USD ($) $ / shares	Jun. 30, 2022 USD ($)	Jun. 30, 2021 USD ($) $ / shares	Dec. 31, 2021 USD ($)	Apr. 30, 2022 USD ($)	Apr. 18, 2022 USD ($)	Mar. 07, 2022 USD ($)	Jan. 01, 2022	Aug. 01, 2017 $ / shares	Dec. 31, 2016 USD ($)	Jul. 31, 2014 $ / shares $ / Item
Liability component
Principal			$ 549,704			$ 549,704		$ 433,484
Debt discount and issuance costs, net			(10,454)			$ (10,454)		(38,831)
2025 Notes
Debt
Debt discount								67,300
Common stock price to current conversion price ratio						130.00%
Average trading price percentage						98.00%
Total issuance costs								5,400
Liability issuance costs								3,500
Equity issuance costs								$ 1,900
Effective interest rate								8.87%
2025 Notes | ASU 2020-06
Debt
Effective interest rate												2.88%
2025 Notes | Common stock
Debt
Share Price | $ / shares													$ 13.28
Convertible senior notes | 2025 Notes
Debt
Ratio of repurchase price to the principal amount						100.00%
Liability component
Principal			192,500			$ 192,500		$ 192,500
Debt discount and issuance costs, net			(2,265)			(2,265)		(38,211)
Net Carrying Amount			190,235			190,235		154,289
Equity component, net			0			0		65,361
Interest expense
Contractual interest expense			1,203		$ 1,203	2,406	$ 2,406
Amortization of debt issuance costs			172		162	343	321
Amortization of debt discount			0		1,951	0	3,862
Total interest and amortization expense			$ 1,375		$ 3,316	$ 2,749	$ 6,589
Convertible senior notes | 2025 Notes | Over-Allotment Option
Debt
Loan amount	$ 17,500
Convertible senior notes | 2025 Notes | Private Placement
Debt
Loan amount	$ 192,500
Debt Instrument, annual interest rate	2.50%
Convertible senior notes | 2025 Notes | Common stock
Debt
Conversion rate for shares of common stock per $1,000 principal	57.9240
Conversion price (dollars per share) | $ / shares	$ 17.26				$ 17.26		$ 17.26
Debt instrument maturity date	Aug. 15, 2025
Conversion premium (as a percent)	30.00%
Convertible senior notes | 2028 Notes
Debt
Loan amount				$ 261,000
Debt instrument maturity date				Mar. 15, 2028
Proceeds from issuance of convertible notes, net of issuance costs				$ 252,600
Common stock price to current conversion price ratio				130.00%
Average trading price percentage				98.00%
Ratio of repurchase price to the principal amount				100.00%
Portion of debt instrument face amount, Exercised				$ 36,000
Effective interest rate			2.70%			2.70%
Liability component
Principal			$ 261,000			$ 261,000		0
Debt discount and issuance costs, net			(8,057)			(8,057)
Net Carrying Amount			252,943			252,943
Interest expense
Contractual interest expense			1,387			1,756
Amortization of debt issuance costs			323			407
Total interest and amortization expense			1,710			$ 2,163
Convertible senior notes | 2028 Notes | Privately-negotiated capped call option
Debt
Cap price for the underlying number of shares (in dollars per share) | $ / Item				33.9850
Purchases of capped calls in connection with convertible senior notes due 2028				$ 21,000
Convertible senior notes | 2028 Notes | Over-Allotment Option
Debt
Loan amount				$ 45,000
Convertible senior notes | 2028 Notes | Private Placement
Debt
Debt Instrument, annual interest rate				2.125%
Convertible senior notes | 2028 Notes | Common stock
Debt
Conversion rate for shares of common stock per $1,000 principal				38.1432
Conversion price (dollars per share) | $ / shares				$ 26.22
Convertible subordinated notes | Privately-negotiated capped call option
Debt
Cap price for the underlying number of shares (in dollars per share) | $ / Item															27.04
Convertible subordinated notes | 2023 Notes
Debt
Loan amount		$ 287,500
Debt Instrument, annual interest rate		2.125%
Conversion price (dollars per share) | $ / shares		$ 27.79													$ 19.77
Debt instrument maturity date		Jan. 15, 2023
Ratio of repurchase price to the principal amount						100.00%
Effective interest rate											2.37%
Debt Instrument, Repurchased Face Amount				$ 144,800							$ 144,800			$ 14,100
Liability component
Principal			96,204			$ 96,204		240,984		$ 96,200	$ 96,200
Debt discount and issuance costs, net			(132)			(132)		$ (620)	$ (200)
Interest expense
Contractual interest expense			511		$ 1,280	1,595	$ 2,560
Amortization of debt issuance costs			59		147	181	288
Total interest and amortization expense			$ 570		$ 1,427	$ 1,776	$ 2,848
Convertible subordinated notes | 2023 Notes | Privately-negotiated capped call option
Debt
Cap price for the underlying number of shares (in dollars per share) | $ / Item		38.00													38.00

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Debt - Debt Maturities (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Long-term debt maturities for years ending December 31:
Remainder of 2022	$ 0
2023	96,204
2024	0
2025	192,500
2026	0
Thereafter	261,000
Total	$ 549,704	$ 433,484

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Commitments and Contingencies (Additional Information) (Details)	6 Months Ended
	Jun. 30, 2022 ft²
Entasis Lease
Lessee, Lease, Description [Line Items]
Operating lease, Weighted average remaining lease term	2 years 9 months 18 days
Operating lease, weighted average incremental borrowing rate	7.80%
Waltham, Massachusetts
Lessee, Lease, Description [Line Items]
Lease space	20,062
Burlingame, California
Lessee, Lease, Description [Line Items]
Lease space	2,111

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Commitments and Contingencies - Schedule of Operating Lease Information Presented In Balance Sheet (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Leases, Operating [Abstract]
Right-of-use assets	$ 3,545	$ 97
Operating Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration]	Liabilities, Current	Liabilities, Current
Lease liabilities, current	$ 687	$ 106
Operating Lease, Liability, Noncurrent, Statement of Financial Position [Extensible Enumeration]	Other Liabilities, Noncurrent	Other Liabilities, Noncurrent
Lease Liabilities, long-term	$ 3,091	$ 0
Total operating lease liabilities	$ 3,778	$ 106

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Commitments and Contingencies (Entasis Lease) (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Future minimum lease payments for years ending December 31:
Total operating lease liabilities	$ 3,778	$ 106
Entasis Therapeutics Holdings Inc
Future minimum lease payments for years ending December 31:
Remainder of 2022	368
2023	1,249
2024	1,269
2025	1,289
Total	4,175
Less: imputed interest	(442)
Total operating lease liabilities	$ 3,733

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Commitments and Contingencies (Burlingame, California) (Details) - Burlingame, California $ in Thousands	Jun. 30, 2022 USD ($)
Lessee, Lease, Description [Line Items]
Remainder of 2022	$ 46
Thereafter	0
Total	$ 46

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Income Taxes (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Income Tax Disclosure [Abstract]
Provisional income tax expense	$ (876)	$ 25,333	$ 5,984	$ 45,069
Effective tax rate (as a percent)			4.30%	18.60%

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Subsequent Events - Additional Information (Details) - Subsequent Event - USD ($) $ / shares in Units, $ in Millions	Jul. 13, 2022	Jul. 11, 2022
Subsequent Event [Line Items]
Business combination, sale of stock transaction date	Jul. 13, 2022
Business combination, percentage of securities sold	15.00%
Upfront cash payment	$ 282.0
Milestone payment	$ 50.0
Entasis Therapeutics Holdings Inc
Subsequent Event [Line Items]
Business acquisition, date of acquisition		Jul. 11, 2022
Business combination, price per share of equity securities acquired		$ 2.20
Business combination, consideration transferred		$ 42.4
La Jolla Pharmaceutical
Subsequent Event [Line Items]
Merger Agreement Effective Date		Jul. 11, 2022
Business combination, price per share of equity securities acquired		$ 6.23