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Equity - Additional Information (Detail) - USD ($)
3 Months Ended
Mar. 31, 2017
Mar. 31, 2016
Dec. 31, 2016
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Stock option outstanding 5,008,441   5,136,110
Stock options, granted 124,998    
Unrecognized stock-based compensation cost $ 5,400,000    
Unrecognized share-based compensation expense, weighted-average recognition period 1 year 2 months 12 days    
Stock compensation expense (gain) $ 1,130,000 $ 787,000  
Research And Development Expense [Member]      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Stock compensation expense (gain) 43,000 (9,000)  
Research And Development Expense [Member] | Warrant [Member]      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Stock compensation expense (gain) $ 0 $ (84,000)  
Non-Employees [Member]      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Stock options, granted 980,834    
Stock option vested 161,667    
Stock option unvested 819,167    
Unrecognized stock-based compensation cost $ 917,000