X0303 4 2010-03-09 0 0001076481 SEQUENOM INC SQNM 0001387409 MYRES LARRY 3595 JOHN HOPKINS COURT SAN DIEGO CA 92121 0 1 0 0 VP, Operations Common Stock 2010-03-09 4 M 0 1078 0 A 11743 D Restricted Stock Unit 2010-03-09 4 M 0 1078 0 D Common Stock 1078 0 D The directly owned common stock holdings reflected in Table I of this form include purchases of 1,217 shares on 1/31/08, 707 shares on 7/31/08, 299 shares on 1/30/09, 1,148 shares on 7/31/09, and 1,641 shares on 1/29/10 pursuant to the Issuer's Employee Stock Purchase Plan. Each restricted stock unit represents a contingent right to receive one share of the Issuer's Common Stock. 100% of the restricted stock units vested on March 9, 2010. By: Clarke Neumann, as attorney-in-fact For: Larry Myres 2010-03-10