Other Financial Information (Tables)

9 Months Ended

Sep. 30, 2013

Other Financial Information [Abstract]

Available-for-sale Securities

Our marketable securities are comprised of the following (in thousands):

	As of September 30, 2013
	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Estimated Fair Value
U.S. treasury securities	$	35,002	$	3	$	—		$	35,005
Certificates of deposit	10,496		—		(6		)	10,490
Mutual funds	230		236		—			466
Total marketable securities	$	45,728	$	239	$	(6	)	$	45,961

	As of December 31, 2012
	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Estimated Fair Value
U.S. treasury securities	$	40,019	$	8	$	(12	)	$	40,015
Certificates of deposit	11,746		1		(9		)	11,738
Mutual funds	224		163		—			387
Total marketable securities	$	51,989	$	172	$	(21	)	$	52,140

Schedule of Inventory, Current

Inventories consist of the following (in thousands):

	September 30, 2013		December 31, 2012
Raw materials	$	17,802	$	8,317
Work in process	949		655
Finished goods	1,483		1,598
Total	$	20,234	$	10,570

Property, Plant and Equipment Disclosure

Property, equipment and leasehold improvements and related accumulated depreciation and amortization are as follows (in thousands):

	September 30, 2013			December 31, 2012
Building and improvements	$	8,687		$	8,660
Laboratory equipment	48,362			42,846
Leasehold improvements	8,122			7,950
Office furniture and equipment	21,109			19,537
	86,280			78,993
Less accumulated depreciation and amortization	(56,373		)	(45,499		)
Total	$	29,907		$	33,494

Schedule of Accrued Liabilities

Accrued expenses consist of the following significant items (in thousands):

	September 30, 2013		December 31, 2012
Accrued royalties, licenses, and collaboration payments	$	10,822	$	5,338
Accrued compensation and related taxes	6,485		11,409
Accrued professional fees and consulting	3,147		2,511
Other	4,378		5,249
Total	$	24,832	$	24,507

Schedule of Stockholders Equity

Changes in shares of common stock outstanding and total stockholders' equity (deficit) are as follows (in thousands):

	Shares of Common Stock Outstanding	Total Stockholders' Equity (Deficit)
Balance as of December 31, 2012	114,787	$	48,007
Net loss	—	(88,531		)
Stock-based compensation	—	7,962
Shares issued or vested under employee stock plans	930	1,372
Unrealized gain on available-for-sale securities	—	73
Foreign currency translation adjustment	—	88
Balance as of September 30, 2013	115,717	$	(31,029	)

Schedule of Accumulated Other Comprehensive Income (Loss)

Changes in accumulated other comprehensive income by component are as follows (in thousands):

	Unrealized Net Gains on Available-for-Sale Securities, net of Deferred Taxes		Foreign Currency Translation Adjustments		Total
Balance as of December 31, 2012	$	97	$	326	$	423
Other comprehensive income	73		88		161
Balance as of September 30, 2013	$	170	$	414	$	584