<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001076352</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001816431</issuerCik>
      <issuerName>Quantum-Si Inc</issuerName>
      <secFileNumber>001-39486</secFileNumber>
      <issuerAddress>
        <com:street1>29 BUSINESS PARK DRIVE</com:street1>
        <com:city>BRANFORD</com:city>
        <com:stateOrCountry>CT</com:stateOrCountry>
        <com:zipCode>06405</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>(203) 458-7100</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ROTHBERG JONATHAN M</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Jefferies</name>
        <address>
          <com:street1>520 Madison Ave</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10022</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>3506267</noOfUnitsSold>
      <aggregateMarketValue>11716541.00</aggregateMarketValue>
      <noOfUnitsOutstanding>142710000</noOfUnitsOutstanding>
      <approxSaleDate>12/27/2024</approxSaleDate>
      <securitiesExchangeName>Nasdaq</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/31/2015</acquiredDate>
      <natureOfAcquisitionTransaction>Private Purchase from Company</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Quantum-Si Inc</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>6250000</amountOfSecuritiesAcquired>
      <paymentDate>12/31/2015</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>12/27/2024</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>09/11/2023</planAdoptionDate>
      </planAdoptionDates>
      <signature>Jonathan M. Rothberg</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
