X0303 4 2010-12-23 0 0001076167 ADOLOR CORP ADLR 0001033516 DOUGHERTY MICHAEL R C/O ADOLOR CORP 700 PENNSYLVANIA DR EXTON PA 19341 1 1 0 0 President & CEO Common Stock 2010-12-23 4 P 0 30000 1.18 A 621911 D This transaction was executed in multiple trades at prices ranging from $1.17 to $1.18. The price reported above reflects the weighted average purchase price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. /s/ John M. Limongelli, as Attorney-in-Fact for Michael R. Dougherty 2010-12-23