<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0508</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2026-03-04</periodOfReport>

    <notSubjectToSection16>false</notSubjectToSection16>

    <issuer>
        <issuerCik>0001075736</issuerCik>
        <issuerName>Crexendo, Inc.</issuerName>
        <issuerTradingSymbol>CXDO</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001550497</rptOwnerCik>
            <rptOwnerName>Vincent Ron</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>1225 W WASHINGTON ST</rptOwnerStreet1>
            <rptOwnerStreet2>STE 213</rptOwnerStreet2>
            <rptOwnerCity>TEMPE</rptOwnerCity>
            <rptOwnerState>AZ</rptOwnerState>
            <rptOwnerZipCode>85288</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>false</isDirector>
            <isOfficer>true</isOfficer>
            <isTenPercentOwner>false</isTenPercentOwner>
            <isOther>false</isOther>
            <officerTitle>Chief Financial Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>false</aff10b5One>

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                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
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                </transactionAcquiredDisposedCode>
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                </sharesOwnedFollowingTransaction>
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        <nonDerivativeTransaction>
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                <transactionCode>M</transactionCode>
                <equitySwapInvolved>false</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>4167</value>
                </transactionShares>
                <transactionPricePerShare>
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                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
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                <sharesOwnedFollowingTransaction>
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                </sharesOwnedFollowingTransaction>
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                <equitySwapInvolved>false</equitySwapInvolved>
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        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
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                <equitySwapInvolved>false</equitySwapInvolved>
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            <transactionAmounts>
                <transactionShares>
                    <value>5000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
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                </transactionAcquiredDisposedCode>
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            <exerciseDate>
                <footnoteId id="F3"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F3"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>5000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>40000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
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        <derivativeTransaction>
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                <equitySwapInvolved>false</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
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                    <value>277</value>
                </transactionShares>
                <transactionPricePerShare>
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                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
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                </underlyingSecurityShares>
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                <sharesOwnedFollowingTransaction>
                    <value>9723</value>
                </sharesOwnedFollowingTransaction>
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        <derivativeTransaction>
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                <equitySwapInvolved>false</equitySwapInvolved>
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                <transactionShares>
                    <value>4167</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
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            <exerciseDate>
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            <expirationDate>
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            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>4167</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
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                <sharesOwnedFollowingTransaction>
                    <value>16667</value>
                </sharesOwnedFollowingTransaction>
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                    <value>D</value>
                </directOrIndirectOwnership>
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        </derivativeTransaction>
        <derivativeTransaction>
            <securityTitle>
                <value>Restricted Stock Units</value>
            </securityTitle>
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                <value>0</value>
                <footnoteId id="F1"/>
            </conversionOrExercisePrice>
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                <transactionCode>A</transactionCode>
                <equitySwapInvolved>false</equitySwapInvolved>
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            <transactionAmounts>
                <transactionShares>
                    <value>70000</value>
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                <transactionPricePerShare>
                    <value>0</value>
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            <exerciseDate>
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            <expirationDate>
                <footnoteId id="F8"/>
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                <underlyingSecurityTitle>
                    <value>Common Stock</value>
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                <underlyingSecurityShares>
                    <value>70000</value>
                </underlyingSecurityShares>
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                <sharesOwnedFollowingTransaction>
                    <value>70000</value>
                </sharesOwnedFollowingTransaction>
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    </derivativeTable>

    <footnotes>
        <footnote id="F1">Each RSU represents the right to receive, upon vesting, one share of CXDO common stock contingent on continued employment.</footnote>
        <footnote id="F2">The Company withheld 1,368 shares of common stock for payment of the associated payroll taxes, using the closing stock price on March 4, 2026 of $6.47. This transaction does not represent a sale by the reporting person.</footnote>
        <footnote id="F3">The RSUs will vest in equal quarterly installments over 12 quarters starting on June 4, 2025 until such time as the RSUs are 100% vested, subject to continuous employment. Shares will be delivered upon vesting.</footnote>
        <footnote id="F4">The Company withheld 76 shares of common stock for payment of the associated payroll taxes, using the closing stock price on March 4, 2026 of $6.47. This transaction does not represent a sale by the reporting person.</footnote>
        <footnote id="F5">The RSUs vest in equal monthly installments over 36 months starting on March 4, 2026 until such time as the RSUs are 100% vested, subject to continuous employment. Shares will be delivered upon vesting.</footnote>
        <footnote id="F6">The RSUs vest in equal quarterly installments over 12 quarters starting on June 5, 2024 until such time as the RSUs are 100% vested, subject to continuous employment. Shares will be delivered upon vesting.</footnote>
        <footnote id="F7">The Company withheld 1,140 shares of common stock for payment of the associated payroll taxes, using the closing stock price on March 5, 2026 of $6.88. This transaction does not represent a sale by the reporting person.</footnote>
        <footnote id="F8">The RSUs will vest in equal quarterly installments over 12 quarters starting on June 4, 2026 until such time as the RSUs are 100% vested, subject to continuous employment. Shares will be delivered upon vesting</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/Ron Vincent</signatureName>
        <signatureDate>2026-03-05</signatureDate>
    </ownerSignature>
</ownershipDocument>
