-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 UFW38osDQpfjYBFthhDxUrT/ENWzkbhRVa0AL36auAqEvBLbJYo/TuAthTnRDCvf
 DjVLNhYSeliV6brA9Q/7RQ==

<SEC-DOCUMENT>0001209191-04-026314.txt : 20040518
<SEC-HEADER>0001209191-04-026314.hdr.sgml : 20040518
<ACCEPTANCE-DATETIME>20040518141618
ACCESSION NUMBER:		0001209191-04-026314
CONFORMED SUBMISSION TYPE:	3/A
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20040426
FILED AS OF DATE:		20040518

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			NORTHWEST BIOTHERAPEUTICS INC
		CENTRAL INDEX KEY:			0001072379
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				943306718
		STATE OF INCORPORATION:			DE

	BUSINESS ADDRESS:	
		STREET 1:		21720-23RD DRIVE SE, SUITE 100
		CITY:			BOTHELL
		STATE:			WA
		ZIP:			98021
		BUSINESS PHONE:		4256083000

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Hemphill Robert F Jr.
		CENTRAL INDEX KEY:			0001289628

	FILING VALUES:
		FORM TYPE:		3/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-33393
		FILM NUMBER:		04815674

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		2404974060

	MAIL ADDRESS:	
		STREET 1:		7600 WISCONSIN AVENUE
		STREET 2:		SUITE 700
		CITY:			BETHESDA
		STATE:			MD
		ZIP:			20814

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Powers Linda F
		CENTRAL INDEX KEY:			0001289624

	FILING VALUES:
		FORM TYPE:		3/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-33393
		FILM NUMBER:		04815677

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		2404974060

	MAIL ADDRESS:	
		STREET 1:		7600 WISCONSIN AVENUE
		STREET 2:		SUITE 700
		CITY:			BETHESDA
		STATE:			MD
		ZIP:			20814

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Robertson Bruce C
		CENTRAL INDEX KEY:			0001289625

	FILING VALUES:
		FORM TYPE:		3/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-33393
		FILM NUMBER:		04815675

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		2404974060

	MAIL ADDRESS:	
		STREET 1:		7600 WISCONSIN AVENUE
		STREET 2:		SUITE 700
		CITY:			BETHESDA
		STATE:			MD
		ZIP:			20814

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Toucan Management, LLC
		CENTRAL INDEX KEY:			0001289626
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		3/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-33393
		FILM NUMBER:		04815673

	BUSINESS ADDRESS:	
		STREET 1:		7600 WISCONSIN AVENUE
		STREET 2:		SUITE 700
		CITY:			BETHESDA
		STATE:			MD
		ZIP:			20814
		BUSINESS PHONE:		2404974060

	MAIL ADDRESS:	
		STREET 1:		7600 WISCONSIN AVENUE
		STREET 2:		SUITE 700
		CITY:			BETHESDA
		STATE:			MD
		ZIP:			20814

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Toucan General II, LLC
		CENTRAL INDEX KEY:			0001289627
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		3/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-33393
		FILM NUMBER:		04815679

	BUSINESS ADDRESS:	
		STREET 1:		7600 WISCONSIN AVENUE
		STREET 2:		SUITE 700
		CITY:			BETHESDA
		STATE:			MD
		ZIP:			20814
		BUSINESS PHONE:		2404974060

	MAIL ADDRESS:	
		STREET 1:		7600 WISCONSIN AVENUE
		STREET 2:		SUITE 700
		CITY:			BETHESDA
		STATE:			MD
		ZIP:			20814

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Toucan Capital Fund II, LP
		CENTRAL INDEX KEY:			0001289580
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		3/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-33393
		FILM NUMBER:		04815678

	BUSINESS ADDRESS:	
		STREET 1:		7600 WISCONSIN AVENUE
		STREET 2:		SUITE 700
		CITY:			BETHESDA
		STATE:			MD
		ZIP:			20814
		BUSINESS PHONE:		2404974060

	MAIL ADDRESS:	
		STREET 1:		7600 WISCONSIN AVENUE
		STREET 2:		SUITE 700
		CITY:			BETHESDA
		STATE:			MD
		ZIP:			20814
</SEC-HEADER>
<DOCUMENT>
<TYPE>3/A
<SEQUENCE>1
<FILENAME>doc3a.xml
<DESCRIPTION>FORM 3/A SUBMISSION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3/A</documentType>

    <periodOfReport>2004-04-26</periodOfReport>

    <dateOfOriginalSubmission>2004-05-06</dateOfOriginalSubmission>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001072379</issuerCik>
        <issuerName>NORTHWEST BIOTHERAPEUTICS INC</issuerName>
        <issuerTradingSymbol>NWBT</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001289580</rptOwnerCik>
            <rptOwnerName>Toucan Capital Fund II, LP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>7600 WISCONSIN AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2>7TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>BETHESDA</rptOwnerCity>
            <rptOwnerState>MD</rptOwnerState>
            <rptOwnerZipCode>20814</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001289624</rptOwnerCik>
            <rptOwnerName>Powers Linda F</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>7600 WISCONSIN AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2>7TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>BETHESDA</rptOwnerCity>
            <rptOwnerState>MD</rptOwnerState>
            <rptOwnerZipCode>20814</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001289625</rptOwnerCik>
            <rptOwnerName>Robertson Bruce C</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>7600 WISCONSIN AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2>7TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>BETHESDA</rptOwnerCity>
            <rptOwnerState>MD</rptOwnerState>
            <rptOwnerZipCode>20814</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001289628</rptOwnerCik>
            <rptOwnerName>Hemphill Robert F Jr.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>7600 WISCONSIN AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2>7TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>BETHESDA</rptOwnerCity>
            <rptOwnerState>MD</rptOwnerState>
            <rptOwnerZipCode>20814</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001289626</rptOwnerCik>
            <rptOwnerName>Toucan Management, LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>7600 WISCONSIN AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2>7TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>BETHESDA</rptOwnerCity>
            <rptOwnerState>MD</rptOwnerState>
            <rptOwnerZipCode>20814</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001289627</rptOwnerCik>
            <rptOwnerName>Toucan General II, LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>7600 WISCONSIN AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2>7TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>BETHESDA</rptOwnerCity>
            <rptOwnerState>MD</rptOwnerState>
            <rptOwnerZipCode>20814</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>10% Convertible Secured Promissory Notes</value>
                <footnoteId id="F1"/>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F5"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F2"/>
            </exerciseDate>
            <expirationDate>
                <value>2005-04-26</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                    <footnoteId id="F3"/>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>8316008.0000</value>
                    <footnoteId id="F4"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>see footnote</value>
                    <footnoteId id="F6"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Warrant</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.0100</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F7"/>
            </exerciseDate>
            <expirationDate>
                <value>2011-04-26</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                    <footnoteId id="F8"/>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>36000000.0000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>see footnote</value>
                    <footnoteId id="F6"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Consists of three 10% Convertible Secured Promissory Notes (the &quot;Notes&quot;), each of which was issued to Toucan Capital Fund II, L.P. (&quot;Toucan Capital&quot;) on April 26, 2004 (the &quot;Issuance Date&quot;). The first Note (which was issued for cash) has a principal amount of $500,000 with interest accruing from the Issuance Date.  The second Note (which was issued in consideration of the cancellation of a $50,000 promissory note originally issued to Toucan Capital on February 2, 2004) has a principal amount of $50,000 with interest accruing from February 2, 2004.  The third Note (which was issued in consideration of the cancellation of a $50,000 promissory note originally issued to Toucan Capital on March 1, 2004) has a principal amount of $50,000 with interest accruing from March 1, 2004.</footnote>
        <footnote id="F2">The aggregate principal amount of, and accrued interest on, the Notes are immediately convertible at the option of Toucan Capital.</footnote>
        <footnote id="F3">The Notes are convertible into any debt or equity security authorized for issuance by the Issuer (currently only Common Stock).</footnote>
        <footnote id="F4">Exclusive of shares issuable upon conversion of accrued interest on the Notes.  As of April 26, 2004, an aggregate of $1,918 of interest was accrued on the Notes, which interest was convertible into an aggregate of 26,581 shares of Common Stock.</footnote>
        <footnote id="F5">The conversion price for a discretionary conversion of the Notes is the lowest of: (i) the lowest nominal or effective price per share paid by any investor at any time on or after April 26, 2003 (subject to certain exceptions); (ii) the lowest nominal or effective price at which any investor is entitled to acquire shares pursuant to any other security, instrument, or promise, undertaking, commitment, agreement or letter of intent of the Issuer outstanding on or after April 26, 2004 or granted, issued, extended or otherwise made available by the Issuer at any time on or after April 26, 2003 (subject to certain exceptions); and (iii) the lesser of $0.10 per share or a 35% discount to the average closing price per share of the Common Stock during any twenty consecutive trading days beginning with the twenty consecutive trading days immediately preceding April 26, 2004 (with the limitation that the conversion price under this clause (iii) will be no less than $0.04 per share).</footnote
>
        <footnote id="F6">Consists of securities held by Toucan Capital.  Toucan General II, LLC (&quot;Toucan General&quot;) is the general partner of Toucan Capital.  Toucan Management, LLC (&quot;Toucan Management&quot;) provides managerial services on behalf of Toucan General pursuant to a management contract.  Linda F. Powers and Robert F. Hemphill, Jr. are managing members of Toucan General and Toucan Management.  Ms. Powers and Mr. Hemphill and Bruce C. Robertson, Ph.D. are members of the investment committee of Toucan Capital.  Each of the reporting persons disclaims beneficial ownership of the shares reported hereon except to the extent of his, her or its respective pecuniary interests therein.</footnote>
        <footnote id="F7">This warrant (the &quot;Warrant&quot;) is exercisable upon the earliest to occur of:  (i) the date that the Issuer has raised at least $2 million through the issuance of any class or series of Equity Security, Debt Security (each as defined in the Recapitalization Agreement) and/or combinations thereof (including, without limitation, any conversion of any Notes (as defined in the Recapitalization Agreement) and/or other convertible or exercisable securities and/or instruments other than the Bridge Warrants (as defined in the Recapitalization Agreement)); (ii) the date that the Issuer breaches any provision of the Recapitalization Agreement or any Related Recapitalization Document (as defined in the Recapitalization Agreement); (iii) the date that the Issuer accepts an Unsolicited Proposal (as defined in the Recapitalization Agreement); or (iv)  sixty one (61) days after recieving notice from Holder of its intention to exercise the warrant.</footnote>
        <footnote id="F8">The Warrant is exercisable for any debt or equity security authorized for issuance by the Issuer (currently only Common Stock).</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ Darren DeStefano, attorney-in-fact</signatureName>
        <signatureDate>2004-05-18</signatureDate>
    </ownerSignature>
</ownershipDocument>

</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----