CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Cash flows from operating activities:
Net loss	$ (41,585)	$ (19,683)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation expense	2,658	2,853
Fair value adjustment of common stock warrants		55
Amortization of intangible asset	132	60
Depreciation of property and equipment	373	302
Deferred income taxes	312
Amortization of debt issuance cost	295	302
Impairment of IPR&D	39,600
Change in fair value of contingent consideration related to Quinsair acquisition	(14,730)
Changes in assets and liabilities:
Accounts receivable	(4,559)	(3,395)
Inventories	(3,178)	4,817
Prepaid expenses and other assets	(1,336)	869
Accounts payable	(698)	(1,305)
Accrued liabilities	791	386
Net cash used in operating activities	(21,925)	(14,739)
Cash flows from investing activities:
Net purchase of property and equipment	(307)	(2,045)
Change in restricted cash	(316)	70
Net cash used in investing activities	(623)	(1,975)
Cash used in financing activities:
Proceeds from the exercise of common stock options and ESPP	41	2,185
Principal payments on debt	(3,000)
Net cash (used in) provided by financing activities	(2,959)	2,185
Effect of exchange rates on cash and cash equivalents	193	(547)
Net decrease in cash and cash equivalents	(25,314)	(15,076)
Cash and cash equivalents, beginning of period	157,352	149,613
Cash and Cash Equivalents, End of Period	132,038	134,537
Supplemental cash flow information:
Interest paid	2,793	2,869
Income taxes paid	$ 85	$ 120