X0202 4 2006-12-14 0 0001070698 TorreyPines Therapeutics, Inc. TPTX 0001370348 Johnson Craig A C/O TORREYPINES THERAPEUTICS, INC. 11085 NORTH TORREY PINES ROAD, SUITE 300 LA JOLLA CA 92037 0 1 0 0 VP Finance, CFO and Secretary stock options 6.37 2006-12-14 4 A 0 25000 0 A 2016-12-13 common stock 25000 25000 D restricted stock options 0 2006-12-14 4 A 0 25000 0 A 2009-03-31 2009-03-31 common stock 25000 25000 D 25% of the options will become exercisable on 12/14/2007. Thereafter, equal portions of the remaining options will become exercisable on the 14th of each month, beginning on 1/14/2008 and continuing through 12/14/2010. Each restricted stock unit represent the right to receive one share of Issuer's common stock if the stock price of the Issuer meets the thresholds described below in footnote (3). Restricted stock units are granted pursuant to the Issuer's 2006 Equity Incentive Plan. Restricted stock unit grants would become exercisable on 3/31/09 if the average stock price (based on average daily closing price) for the 6-month period ending 3/31/09 is at or above $10.36. Additional conditions may also apply pursuant to the terms of the Reporting Person's grant and/or employment agreement. Restricted stock unit grants will terminate on 3/31/09 if conditions are not met (see footnote 3 above). Expiration date is also subject to the terms of Reporting Person's grant agreement. /s/ Agatha M. Martindale, Attorney-in-fact 2006-12-18