X0201 4 2003-11-18 0 0001070698 AXONYX INC AXYX 0001250856 BRUINSMA GOSSE B 500 SEVENTH AVENUE 10TH FLOOR NEW YORK NY 10018 1 1 0 0 President & Chief Operating Of Non-Statutory Stock Option 3.61 2003-11-18 4 A 0 100000 3.61 A 2003-11-18 2013-11-17 Common Stock 100000 100000 D These non-statutory stock options were granted on November 18, 2003 and the grant provides for vesting in four equal annual installments commencing with the vesting of 25,000 options on November 18, 2003. /s/ Gosse B. Bruinsma, M.D. 2003-11-19