<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001578852</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001070081</issuerCik>
      <issuerName>PTC THERAPEUTICS, INC.</issuerName>
      <secFileNumber>001-35969</secFileNumber>
      <issuerAddress>
        <com:street1>500 WARREN CORPORATE CENTER DRIVE</com:street1>
        <com:city>WARREN</com:city>
        <com:stateOrCountry>NJ</com:stateOrCountry>
        <com:zipCode>07059</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>9082227000</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Boulding Mark Elliott</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Brokerage Services LLC</name>
        <address>
          <com:street1>900 Salem Street</com:street1>
          <com:city>Smithfield</com:city>
          <com:stateOrCountry>RI</com:stateOrCountry>
          <com:zipCode>02917</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>2813</noOfUnitsSold>
      <aggregateMarketValue>194490.82</aggregateMarketValue>
      <noOfUnitsOutstanding>80288305</noOfUnitsOutstanding>
      <approxSaleDate>02/17/2026</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>02/17/2026</acquiredDate>
      <natureOfAcquisitionTransaction>Option Granted 02/15/2024</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>2813</amountOfSecuritiesAcquired>
      <paymentDate>02/17/2026</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Mark Boulding</name>
        <address>
          <com:street1>500 Warren Corporate Center Drive</com:street1>
          <com:city>Warren</com:city>
          <com:stateOrCountry>NJ</com:stateOrCountry>
          <com:zipCode>07059</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>11/17/2025</saleDate>
      <amountOfSecuritiesSold>2812</amountOfSecuritiesSold>
      <grossProceeds>213690.35</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Mark Boulding</name>
        <address>
          <com:street1>500 Warren Corporate Center Drive</com:street1>
          <com:city>Warren</com:city>
          <com:stateOrCountry>NJ</com:stateOrCountry>
          <com:zipCode>07059</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>01/05/2026</saleDate>
      <amountOfSecuritiesSold>2266</amountOfSecuritiesSold>
      <grossProceeds>171190.18</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Mark Boulding</name>
        <address>
          <com:street1>500 Warren Corporate Center Drive</com:street1>
          <com:city>Warren</com:city>
          <com:stateOrCountry>NJ</com:stateOrCountry>
          <com:zipCode>07059</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>01/06/2026</saleDate>
      <amountOfSecuritiesSold>1739</amountOfSecuritiesSold>
      <grossProceeds>133811.88</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Mark Boulding</name>
        <address>
          <com:street1>500 Warren Corporate Center Drive</com:street1>
          <com:city>Warren</com:city>
          <com:stateOrCountry>NJ</com:stateOrCountry>
          <com:zipCode>07059</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>01/07/2026</saleDate>
      <amountOfSecuritiesSold>4879</amountOfSecuritiesSold>
      <grossProceeds>377839.55</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Mark Boulding</name>
        <address>
          <com:street1>500 Warren Corporate Center Drive</com:street1>
          <com:city>Warren</com:city>
          <com:stateOrCountry>NJ</com:stateOrCountry>
          <com:zipCode>07059</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>01/08/2026</saleDate>
      <amountOfSecuritiesSold>4033</amountOfSecuritiesSold>
      <grossProceeds>308761.28</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Mark Boulding</name>
        <address>
          <com:street1>500 Warren Corporate Center Drive</com:street1>
          <com:city>Warren</com:city>
          <com:stateOrCountry>NJ</com:stateOrCountry>
          <com:zipCode>07059</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>01/09/2026</saleDate>
      <amountOfSecuritiesSold>2314</amountOfSecuritiesSold>
      <grossProceeds>180314.42</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>02/17/2026</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>12/04/2024</planAdoptionDate>
      </planAdoptionDates>
      <signature>/s/ Eric Janiak, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Mark Boulding</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
