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Debt - Narrative (Details)
1 Months Ended 9 Months Ended
May 05, 2017
USD ($)
May 31, 2017
USD ($)
Aug. 31, 2015
USD ($)
day
$ / shares
Sep. 30, 2017
USD ($)
Dec. 31, 2016
USD ($)
Convertible debt | 3.00% Convertible senior notes due 2022          
Long-term debt          
Debt principal amount     $ 150,000,000.0 $ 150,000,000 $ 150,000,000
Interest rate     3.00%    
Net proceeds from issuance of convertible notes     $ 145,400,000    
Trading days, number | day     20    
Consecutive trading days, period | day     30    
Stock price trigger     130.00%    
Business days, period     5 days    
Consecutive trading-day period     5 days    
Common stock per principal amount     $ 1,000    
Maximum product of the closing sale price of shares of the Company's common stock and the applicable conversion rate for such trading day     98.00%    
Conversion ratio     17.7487    
Conversion price per share (in dollars per share) | $ / shares     $ 56.34    
Convertible instruments principal and unpaid interest payable upon events of default     100.00%    
Minimum percentage of principal held by convertible debt instrument holders required to issue notice for declaration of principal and unpaid interest payable upon events of default     25.00%    
Term of the convertible notes     7 years    
Adjustments to additional paid in capital, equity component of convertible debt     $ 57,500,000    
Net deferred tax liability in connection with convertible notes     $ 22,300,000    
Fair value of convertible notes       $ 120,300,000  
Remaining contractual life of the convertible notes       4 years 10 months 17 days  
Convertible debt | 3.00% Convertible senior notes due 2022 | Redemption on or after August 20, 2018          
Long-term debt          
Trading days, number | day     19    
Consecutive trading days, period | day     30    
Stock price trigger     130.00%    
Redemption price     100.00%    
Sinking fund     $ 0    
MidCap Financial Trust          
Long-term debt          
Line of credit facility, maximum borrowing capacity   $ 60,000,000      
Proceeds from lines of credit $ 40,000,000        
Line of credit facility, additional capacity available, net product revenue threshold   20,000,000      
Line of credit facility, net product revenue threshold, additional capacity   $ 120,000,000      
Line of credit facility, net product revenue threshold, additional capacity, trailing period   12 months      
Debt issuance costs   $ 400,000      
Debt instrument, floor interest rate   1.00%      
Debt instrument, basis spread on variable rate   6.15%      
Debt instrument, interest payment period   24 months