Consolidated Statements of Operations (unaudited) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2017	Sep. 30, 2016	Sep. 30, 2017	Sep. 30, 2016
Revenues:
Net product revenue	$ 41,780	$ 22,013	$ 116,113	$ 56,328
Collaboration and grant revenue	73	973	249	1,186
Total revenues	41,853	22,986	116,362	57,514
Operating expenses:
Cost of product sales, excluding amortization of acquired intangible asset	1,582	0	2,142	0
Amortization of acquired intangible asset	9,716	0	9,952	0
Research and development	30,024	31,396	88,222	91,622
Selling, general and administrative	31,423	23,654	85,788	72,958
Total operating expenses	72,745	55,050	186,104	164,580
Loss from operations	(30,892)	(32,064)	(69,742)	(107,066)
Interest expense, net	(3,421)	(2,133)	(8,648)	(6,149)
Other income (expense), net	766	(786)	(1,373)	(1,893)
Loss before income tax expense	(33,547)	(34,983)	(79,763)	(115,108)
Income tax expense	(191)	(184)	(507)	(206)
Net loss attributable to common stockholders	$ (33,738)	$ (35,167)	$ (80,270)	$ (115,314)
Weighted-average shares outstanding:
Basic and diluted (in shares)	41,296,740	34,088,741	38,433,749	34,002,952
Net loss per share-basic and diluted (in dollars per share)
Net loss per share—basic and diluted (in dollars per share)	$ (0.82)	$ (1.03)	$ (2.09)	$ (3.39)