<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:ns1="http://www.sec.gov/edgar/common">
  <schemaVersion>X0202</schemaVersion>
<headerData>
    <submissionType>SCHEDULE 13G/A</submissionType>
    <previousAccessionNumber>0000947263-26-000005</previousAccessionNumber>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0000947263</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <amendmentNo>1</amendmentNo>
      <securitiesClassTitle>Common Stock, $0.001 par value per share</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>03/31/2026</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001070081</issuerCik>
        <issuerName>PTC THERAPEUTICS, INC.</issuerName>
        <issuerCusips>
          <issuerCusipNumber>69366J200</issuerCusipNumber>
        </issuerCusips>
        <issuerPrincipalExecutiveOfficeAddress>
          <ns1:street1>500 WARREN CORPORATE CENTER DRIVE</ns1:street1>
          <ns1:city>WARREN</ns1:city>
          <ns1:stateOrCountry>NJ</ns1:stateOrCountry>
          <ns1:zipCode>07059</ns1:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(b)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>The Toronto-Dominion Bank</reportingPersonName>
      <citizenshipOrOrganization>Z4</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>3025945</soleVotingPower>
        <sharedVotingPower>0</sharedVotingPower>
        <soleDispositivePower>3025945</soleDispositivePower>
        <sharedDispositivePower>0</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>3025945</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>3.7</classPercent>
      <typeOfReportingPerson>FI</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>PTC THERAPEUTICS, INC.</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>500 WARREN CORPORATE CENTER DRIVE, WARREN, NEW JERSEY
07059</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>The Toronto-Dominion Bank</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>66 Wellington Street West
12th Floor TD Tower
Toronto, Ontario, Canada
M5K 1A2</principalBusinessOfficeOrResidenceAddress>
        <citizenship>The Toronto-Dominion Bank - CANADA (FEDERAL LEVEL)</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>N</notApplicableFlag>
        <typeOfPersonFiling>FI</typeOfPersonFiling>
        <otherTypeOfPersonFiling>Bank</otherTypeOfPersonFiling>
      </item3>
      <item4>
        <amountBeneficiallyOwned>3,025,945</amountBeneficiallyOwned>
        <classPercent>3.7</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>The Toronto-Dominion Bank - 3,025,945</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>The Toronto-Dominion Bank - 0</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>The Toronto-Dominion Bank - 3,025,945</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>The Toronto-Dominion Bank - 0</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>N</notApplicableFlag>
        <classOwnership5PercentOrLess>Y</classOwnership5PercentOrLess>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.</certifications>
      </item10>
    </items>
    <signatureInformation>
      <reportingPersonName>The Toronto-Dominion Bank</reportingPersonName>
      <signatureDetails>
        <signature>Christina Petrou</signature>
        <title>Christina Petrou / Executive Vice President and Chief Operating Officer</title>
        <date>05/15/2026</date>
      </signatureDetails>
    </signatureInformation>
  </formData>
</edgarSubmission>
