X0303 4 2009-06-26 0000904973 GTC BIOTHERAPEUTICS INC GTCB 0001069576 TUCK ALAN W C/O GTC BIOTHERAPEUTICS, INC. 175 CROSSING BOULEVARD FRAMINGHAM MA 01702 1 0 0 0 Common Stock 2009-06-26 4 A 0 556 2.70 A 3268 D Common Stock 700 I By IRA Shares acquired at Mr. Tuck's election to receive common stock in lieu of the quarterly cash payment of his 2009 director retainer fees and issued pursuant to GTC's 2002 Equity Incentive Plan. On May 26, 2009 the issuer effected a one-for-ten reverse stock split of its outstanding common stock, resulting in the reporting person owning 24,414 fewer shares of common stock. On May 26, 2009 the issuer effected a one-for-ten reverse stock split of its outstanding common stock, resulting in the reporting person owning 6,300 fewer shares of common stock in his IRA. /s/ Nathaniel S. Gardiner as attorney-in-fact for Alan W. Tuck 2009-06-29