Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

We consent to the reference to our firm under the caption “Experts” in the Registration Statement (Form S-3) and related Prospectus of Cassava Sciences, Inc. for the registration of common stock, preferred stock, depository shares, warrants, rights, debt securities, and units, and to the incorporation by reference therein of our report dated March 26, 2020, with respect to the financial statements of Cassava Sciences, Inc. included in its Annual Report (Form 10-K) for the year ended December 31, 2019, filed with the Securities and Exchange Commission.

/s/ Ernst & Young LLP

Austin, Texas

February 10, 2021