Stockholders' (Deficit) Equity (Tables)

9 Months Ended

Sep. 30, 2022

Equity [Abstract]

Summary of Option Activity under 2018 Plan, 2013 Plan and 2010 Plan

A summary of option activity under the 2018 Plan, 2013 Plan, and 2010 Plan for the nine months ended September 30, 2022, is as follows:

Year-to-Date Activity	Number of Shares			Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (Years)		Aggregate Intrinsic Value (in Millions)
Options outstanding at December 31, 2021		1,954,975		$	8.16		7.8
Granted		960,500		$	2.33
Cancelled/forfeited		(85,000	)	$	3.75
Options outstanding at September 30, 2022		2,830,475		$	6.32		7.8	$	—
Options exercisable at September 30, 2022		1,398,730		$	9.64		6.5	$	—

Summary of Stock-Based Compensation Expense

The fair value of shares vested during the three and nine months ending September 30, 2022 was $0.4 million and $1.9 million, respectively. The fair value of shares vested during the three and nine months ending September 30, 2021 was $0.5 million and $1.6 million, respectively. The amount of stock-based compensation expense recorded to research and development expenses and to general and administrative expenses is detailed in table below:

	Three Months Ended September 30,				Nine Months Ended September 30,
	2022		2021		2022		2021
Stock-based compensation
Research and development	$	160,316	$	183,505	$	459,636	$	528,385
General and administrative		299,799		416,508		935,353		1,226,027
Total stock-based compensation expense	$	460,115	$	600,013	$	1,394,989	$	1,754,412

Summary of Warrants Issued

	Nine Months Ended September 30,
	2022				2021
	Number		Weighted Average Exercise Price		Number		Weighted Average Exercise Price
Outstanding at beginning of the period		—	$	—		—		—
Granted during the period		250,000		2.08		—		—
Outstanding at end of the period		250,000	$	2.08		—	$	—
Exercisable at end of the period		250,000	$	2.08		—	$	—
Weighted average remaining life	6.5 years					—