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Stockholders' (Deficit) Equity (Tables)
 12 Months Ended
Dec. 31, 2021
Equity [Abstract]  
Summary of Option Activity under 2018 Plan, 2013 Plan and 2010 Plan

A summary of option activity under the 2018 Plan, 2013 Plan, and 2010 Plan for the year ended December 31, 2021 is as follows:

 

 

Number of

Shares

 

 

Weighted

Average

Exercise

Price

 

 

Weighted

Average

Remaining

Contractual

Term (Years)

 

 

Aggregate

Intrinsic

Value (in Thousands)

 

Options outstanding at December 31, 2020

 

 

1,240,354

 

 

$

11.16

 

 

 

7.8

 

 

 

 

 

Granted

 

 

733,500

 

 

$

3.41

 

 

 

 

 

 

 

 

 

Cancelled/forfeited

 

 

(18,879

)

 

$

20.37

 

 

 

 

 

 

 

 

 

Options outstanding at December 31, 2021

 

 

1,954,975

 

 

$

8.16

 

 

 

7.8

 

 

$

2

 

Options exercisable at December 31, 2021

 

 

894,879

 

 

$

11.94

 

 

 

6.6

 

 

$

—

 
Summary of Stock-Based Compensation Expense

 

 

 

Years Ended December 31,

 

 

 

2021

 

 

2020

 

Stock-based compensation expense

 

 

 

 

 

 

 

 

Research and development

 

$

696,283

 

 

$

764,526

 

General and administrative

 

 

1,590,724

 

 

 

1,459,620

 

Total stock-based compensation expense

 

$

2,287,007

 

 

$

2,224,146