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Nature of Operations and Basis of Presentation - Additional Information (Details)
1 Months Ended 12 Months Ended
Mar. 18, 2020
USD ($)
Sep. 19, 2017
Jun. 30, 2019
Employee
Dec. 31, 2019
USD ($)
$ / shares
shares
Dec. 31, 2018
USD ($)
$ / shares
shares
May 15, 2018
$ / shares
May 14, 2018
$ / shares
Organization Consolidation and Presentation of Financial Statement [Line Items]              
Restructuring implemented date       Jun. 30, 2019      
Corporate restructuring, reduction of full-time workforce percentage     60.00%        
Corporate restructuring, reduction of full-time workforce employees | Employee     48        
Restructuring completion date       Dec. 31, 2019      
Preferred stock, no par value             $ 0
Preferred stock, par value       $ 0.0001 $ 0.0001    
Common stock, par value       $ 0.0001 $ 0.0001   $ 0.01
Accumulated deficit | $       $ 76,250,512 $ 46,832,543    
Cash and cash equivalents | $       12,077,640 41,671,284    
Net cash used in operating activities | $       $ 29,506,949 $ 16,587,803    
Common stock, shares issued | shares       10,095,176 10,087,363    
At-the-Market Facility              
Organization Consolidation and Presentation of Financial Statement [Line Items]              
Common stock, shares issued | shares       0      
At-the-Market Facility | Subsequent Event | Maximum              
Organization Consolidation and Presentation of Financial Statement [Line Items]              
Aggregate offering price of common stock | $ $ 50,000,000            
Merger of Private Acer with opexa therapeutics incorporation and Opexa Merger Sub Incorporation              
Organization Consolidation and Presentation of Financial Statement [Line Items]              
Business combination date of completion   Sep. 19, 2017          
Business combination date of agreement   Jun. 30, 2017          
Reverse stock split ratio   0.09656678989          
Delaware Reincorporation and Subsidiary Merger              
Organization Consolidation and Presentation of Financial Statement [Line Items]              
Merger incorporation description       On May 15, 2018, the Company changed its state of incorporation from the State of Texas to the State of Delaware pursuant to a plan of conversion, dated May 15, 2018. As a result of this reincorporation, the par value of the Company’s preferred stock was changed to $0.0001 from no par value and the par value of the Company’s common stock was reduced to $0.0001 from $0.01. Immediately following the Reincorporation, the Company’s holding company structure was eliminated by merging wholly-owned subsidiary Private Acer with and into the Company (the “Subsidiary Merger”). The Company was the surviving corporation in connection with the Subsidiary Merger.      
Date of reincorporation       May 15, 2018      
Preferred stock, par value           $ 0.0001  
Common stock, par value           $ 0.0001