X0306 4 2016-05-16 0 0001069308 Opexa Therapeutics, Inc. OPXA 0001359850 Seaman Scott B C/O OPEXA THERAPEUTICS, INC. 2635 TECHNOLOGY FOREST BLVD. THE WOODLANDS TX 77381 1 Common Stock 2016-05-16 4 A 0 6455 0 A 17079 D Common Stock 129676 I see footnote (1) Held by Alkek and Williams Ventures, Ltd. ("Ventures"). Chaswil, Ltd. ("Chaswil") is the investment manager of Ventures and holds voting power and investment power with respect to the Issuer securities held by Ventures. Mr. Seaman is a registered principal of Chaswil and has shared voting power and/or investment power with respect to the Issuer securities held by Ventures. Mr. Seaman disclaims beneficial ownership of the shares held by Ventures except to the extent of any pecuniary interest therein. /s/ Neil Warma, attorney in fact 2016-05-18