X0202 4 2006-06-15 0 0001069308 Opexa Therapeutics, Inc. pftr.ob 0001293831 Rouse William 2635 N. CRESCENT RIDGE DRIVE THE WOODLANDS TX 77381 0 1 0 0 CFO Common Stock Options (right to buy) 5 2006-06-15 5 A 0 E 65000 A 2011-05-02 Common Stock 65000 80000 D Common Stock Options (right to buy) 5 2006-06-15 5 A 0 E 10000 A 2011-05-02 Common Stock 10000 90000 D Common Stock Options (right to buy) 30 2010-01-21 Common Stock 5000 15000 D Common Stock Options (right to buy) 30 2009-04-29 Common Stock 10000 10000 D As adjusted to reflect a one-for-ten reverse stock split of the Issuer's common stock effective June 15, 2006. 21,667 shares of Issuer's common stock shall vest on May 2, 2006, and 43,333 shares shall vest on April 28, 2007. For services rendered to the Issuer as an executive officer. 10,000 shares of Issuer's common stock shall vest on the date the Issuer's registration statement is deemed effective by the SEC. Vests in three equal installments on January 21, 2005, January 21, 2006, and January 21, 2007. Vests in three installments on April 29, 2005, 2006 and 2007. No new options acquired. /s/C. William Rouse 2006-06-15