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        <entityName>Acer Therapeutics Inc.</entityName>
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            <street2>300 Washington Street</street2>
            <city>Newton</city>
            <stateOrCountry>MA</stateOrCountry>
            <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
            <zipCode>02458</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>(844) 902-6100</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <previousName>Acer Reincorporation, Inc.</previousName>
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            <previousName>Opexa Therapeutics, Inc.</previousName>
            <previousName>PharmaFrontiers Corp.</previousName>
            <previousName>PHARMAFRONTIERS CORP</previousName>
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        <entityType>Corporation</entityType>
        <yearOfInc>
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            <value>2018</value>
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                <firstName>Chris</firstName>
                <lastName>Schelling</lastName>
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                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>02458</zipCode>
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                <relationship>Director</relationship>
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                <lastName>Aselage</lastName>
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        <relatedPersonInfo>
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                <firstName>Harry</firstName>
                <middleName>S</middleName>
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        <relatedPersonInfo>
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    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2020-07-24</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
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            <totalAmountSold>857493</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>5</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
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                <dollarAmount>0</dollarAmount>
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            <findersFees>
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            <clarificationOfResponse></clarificationOfResponse>
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                <dollarAmount>0</dollarAmount>
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            <clarificationOfResponse></clarificationOfResponse>
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        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Acer Therapeutics Inc.</issuerName>
                <signatureName>/s/ Harry S. Palmin</signatureName>
                <nameOfSigner>Harry S. Palmin</nameOfSigner>
                <signatureTitle>Chief Operating Officer and Chief Financial Officer</signatureTitle>
                <signatureDate>2020-07-28</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
