<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2018-04-16</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001069308</issuerCik>
        <issuerName>Acer Therapeutics Inc.</issuerName>
        <issuerTradingSymbol>ACER</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001319460</rptOwnerCik>
            <rptOwnerName>Joseph Donald</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O ACER THERAPEUTICS INC.</rptOwnerStreet1>
            <rptOwnerStreet2>ONE GATEWAY CTR., STE 351</rptOwnerStreet2>
            <rptOwnerCity>NEWTON</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02458</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Chief Legal Officer and Secy</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <footnotes></footnotes>

    <remarks>Exhibit List: Exhibit 24 - Confirming Statement
No securities are beneficially owned.</remarks>

    <ownerSignature>
        <signatureName>/s/ Donald Joseph</signatureName>
        <signatureDate>2018-04-23</signatureDate>
    </ownerSignature>
</ownershipDocument>
