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&lt;p style="MARGIN-TOP: 18px; MARGIN-BOTTOM: 0px"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;&lt;b&gt;Note 11. Subsequent
Events&lt;/b&gt;&lt;/font&gt;&lt;/p&gt;
&lt;p style="MARGIN-TOP: 6px; TEXT-INDENT: 4%; MARGIN-BOTTOM: 0px"&gt;
&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;Subsequent to
March 31, 2013, Opexa granted its directors, officers and employees
options to purchase an aggregate of 207,822 shares of common stock
with a fair value of $356,335 at an exercise price of
$1.75.&lt;/font&gt;&lt;/p&gt;
&lt;p style="MARGIN-TOP: 12px; TEXT-INDENT: 4%; MARGIN-BOTTOM: 0px"&gt;
&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;Subsequent to
March 31, 2013, Opexa issued 123,231 shares of common stock to the
Noteholders of the July 2012 Notes as payment of accrued interest
through June 30, 2013.&lt;/font&gt;&lt;/p&gt;
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&lt;p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;&lt;b&gt;Note 14. Subsequent
Events&lt;/b&gt;&lt;/font&gt;&lt;/p&gt;
&lt;p style="MARGIN-TOP: 6px; TEXT-INDENT: 4%; MARGIN-BOTTOM: 0px"&gt;
&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;In January
2013, 125,000 shares of common stock were sold and 975 additional
commitment shares were issued to Lincoln Park under the $1.5
million purchase agreement for net proceeds of $142,400.&lt;/font&gt;&lt;/p&gt;
&lt;p style="MARGIN-TOP: 12px; TEXT-INDENT: 4%; MARGIN-BOTTOM: 0px"&gt;
&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;On
January&amp;#xA0;23, 2013, Opexa closed a private offering consisting
of convertible notes (the &amp;#x201C;January 2013 Notes&amp;#x201D;) and
warrants to purchase shares of common stock for gross proceeds of
$650,000 of which $100,000 was from a related party. The January
2013 Notes&amp;#xA0;were scheduled to mature on January&amp;#xA0;23, 2014
and accrued interest at the rate of 12%&amp;#xA0;per annum, compounded
annually. The January 2013 Notes were convertible into common stock
at the option of the investors at a price of $1.30 per share,
subject to certain limitations. The principal balance plus accrued
was payable within five business days of the receipt by Opexa of an
aggregate of at least $7.5 million in proceeds from the sale of its
equity securities and/or as payments from one or more partners or
potential partners in return for granting a license, other rights,
or an option to license or otherwise acquire rights with respect to
Tcelna. On February&amp;#xA0;26, 2013, following the receipt of
proceeds in excess of $7.5 million, Opexa paid principal and
interest totaling $567,368 to holders of the January 2013 Notes and
issued 77,034 shares of common stock to one holder of the January
2013 Notes who elected to convert the principal into common
stock.&lt;/font&gt;&lt;/p&gt;
&lt;p style="MARGIN-TOP: 12px; TEXT-INDENT: 4%; MARGIN-BOTTOM: 0px"&gt;
&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;The&amp;#xA0;warrants related to the January 2013 Notes financing
have an exercise price of $1.24 per share, a five-year term and are
exercisable for&amp;#xA0;a maximum of 243,750 shares of common stock,
subject to certain limitations. The Company can redeem the warrants
at $0.01 per share if the Company&amp;#x2019;s common stock closes at or
above $10.00 per share for 20 consecutive trading days.&lt;/font&gt;&lt;/p&gt;
&lt;p style="MARGIN-TOP: 12px; TEXT-INDENT: 4%; MARGIN-BOTTOM: 0px"&gt;
&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;Pursuant to the
convertible secured promissory note financing effected by Opexa on
July&amp;#xA0;25, 2012 (the &amp;#x201C;July 2012 Notes&amp;#x201D;), $1.0
million of the gross proceeds are maintained in a segregated
account and subject to a deposit control agreement while the July
2012 Notes are outstanding. Pursuant to a waiver executed by the
holders of in excess of two-thirds (66-2/3%) of the principal
amount of the outstanding July 2012 Notes and accepted by Opexa,
the amount of the cash subject to the deposit control agreement was
reduced to $500,000 on January&amp;#xA0;29, 2013. In exchange for such
waiver, the Company issued warrants to the holders of the July 2012
Notes to purchase an aggregate of 187,500 shares of the
Company&amp;#x2019;s common stock. The&amp;#xA0;warrants have an exercise
price of $1.21 per share and a five-year term. The Company can
redeem the warrants at $0.01 per underlying share of common stock
if the common stock closes at or above $10.00 per share for 20
consecutive trading days.&lt;/font&gt;&lt;/p&gt;
&lt;p style="MARGIN-TOP: 12px; TEXT-INDENT: 4%; MARGIN-BOTTOM: 0px"&gt;
&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;In February
2013, three of the holders of the July 2012 Notes elected to
convert an aggregate of $900,000 of the July 2012 Notes into shares
of the Company&amp;#x2019;s Series A convertible preferred stock with
further immediate conversion into shares of the Company&amp;#x2019;s
common stock. Accordingly, the Company issued an aggregate of
288,229 shares of common stock to the holders.&lt;/font&gt;&lt;/p&gt;
&lt;p style="MARGIN-TOP: 12px; TEXT-INDENT: 4%; MARGIN-BOTTOM: 0px"&gt;
&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;In February
2013, Opexa sold an aggregate of 167,618 shares of common stock
under the ATM Agreement dated September&amp;#xA0;6, 2012 for gross
proceeds of $536,417. Under the ATM Agreement, Opexa may sell an
aggregate of up to 1,000,000 shares of common stock from time to
time through the placement agent with a commission equal to 3% of
the gross proceeds. Opexa paid compensation and fees totaling
$16,105 to the placement agent with respect to the shares
sold.&lt;/font&gt;&lt;/p&gt;
&lt;p style="MARGIN-TOP: 12px; TEXT-INDENT: 4%; MARGIN-BOTTOM: 0px"&gt;
&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;On
February&amp;#xA0;4, 2013, Opexa entered into an option and license
agreement with Merck. Pursuant to the agreement, Merck has an
option to acquire an exclusive, worldwide (excluding Japan) license
of the Company&amp;#x2019;s Tcelna program for the treatment of multiple
sclerosis. Under the terms of the agreement, the Company received
an upfront payment of $5 million on February&amp;#xA0;20,
2013.&lt;/font&gt;&lt;/p&gt;
&lt;p style="MARGIN-TOP: 12px; TEXT-INDENT: 4%; MARGIN-BOTTOM: 0px"&gt;
&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;On
February&amp;#xA0;11, 2013, Opexa sold an aggregate of 1,083,334 units
in a registered offering, with each unit consisting of one share of
common stock and a warrant to purchase half (0.5) a share of common
stock, at a price of $3.00 per unit, for gross proceeds of
$3,250,002. The shares of common stock and warrants were
immediately separable and were issued separately such that no units
were issued. The warrants are exercisable immediately upon
issuance, have a four-year term and an exercise price of $3.00 per
share. A fee of 6.0% of the gross proceeds was paid to the
placement agent.&lt;/font&gt;&lt;/p&gt;
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