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Consolidated Statements of Cash Flows (USD $)
12 Months Ended
Dec. 31, 2014
Dec. 31, 2013
Cash flows from operating activities    
Net loss $ (15,052,263)us-gaap_NetIncomeLoss $ (16,656,325)us-gaap_NetIncomeLoss
Adjustments to reconcile net loss to net cash used in operating activities    
Stock issued for services 306,103us-gaap_IssuanceOfStockAndWarrantsForServicesOrClaims 69,899us-gaap_IssuanceOfStockAndWarrantsForServicesOrClaims
Amortization of discount on notes payable due to warrants and beneficial conversion feature 0us-gaap_AmortizationOfDebtDiscountPremium 1,613,354us-gaap_AmortizationOfDebtDiscountPremium
Loss on extinguishment of debt 0us-gaap_GainsLossesOnExtinguishmentOfDebt 2,518,912us-gaap_GainsLossesOnExtinguishmentOfDebt
Depreciation 387,779us-gaap_Depreciation 335,597us-gaap_Depreciation
Amortization of debt financing costs 0us-gaap_AmortizationOfFinancingCosts 125,248us-gaap_AmortizationOfFinancingCosts
Option and warrant expense 959,898opxa_OptionAndWarrantExpense 1,129,640opxa_OptionAndWarrantExpense
Loss on disposal of fixed assets 0us-gaap_GainLossOnDispositionOfAssets 2,161us-gaap_GainLossOnDispositionOfAssets
Changes in:    
Other current assets 363,633us-gaap_IncreaseDecreaseInOtherCurrentAssets 104,051us-gaap_IncreaseDecreaseInOtherCurrentAssets
Accounts payable 6,339us-gaap_IncreaseDecreaseInAccountsPayable 147,923us-gaap_IncreaseDecreaseInAccountsPayable
Accrued expenses (33,806)us-gaap_IncreaseDecreaseInAccruedLiabilities 928,549us-gaap_IncreaseDecreaseInAccruedLiabilities
Other assets 138,727us-gaap_IncreaseDecreaseInOtherOperatingAssets (177,667)us-gaap_IncreaseDecreaseInOtherOperatingAssets
Deferred revenue (1,271,895)us-gaap_IncreaseDecreaseInDeferredRevenue 3,733,389us-gaap_IncreaseDecreaseInDeferredRevenue
Net cash used in operating activities (14,195,485)us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations (6,125,269)us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations
Cash flows from investing activities    
Purchase of property & equipment (190,859)us-gaap_PaymentsToAcquirePropertyPlantAndEquipment (259,224)us-gaap_PaymentsToAcquirePropertyPlantAndEquipment
Restricted cash 0us-gaap_IncreaseDecreaseInRestrictedCash 1,000,000us-gaap_IncreaseDecreaseInRestrictedCash
Net cash provided by (used in) investing activities (190,859)us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations 740,776us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations
Cash flows from financing activities    
Common stock and warrants sold for cash, net of offering costs 648,175us-gaap_ProceedsFromIssuanceOrSaleOfEquity 28,484,878us-gaap_ProceedsFromIssuanceOrSaleOfEquity
Proceeds from third party debt 0us-gaap_ProceedsFromDebtNetOfIssuanceCosts 550,000us-gaap_ProceedsFromDebtNetOfIssuanceCosts
Proceeds from related party debt 0us-gaap_ProceedsFromRelatedPartyDebt 100,000us-gaap_ProceedsFromRelatedPartyDebt
Deferred financing and offering costs 0us-gaap_PaymentsOfFinancingCosts (147,847)us-gaap_PaymentsOfFinancingCosts
Repayment on related party notes payable 0us-gaap_RepaymentsOfRelatedPartyDebt (100,000)us-gaap_RepaymentsOfRelatedPartyDebt
Repayments on notes payable 0us-gaap_RepaymentsOfNotesPayable (450,000)us-gaap_RepaymentsOfNotesPayable
Net cash provided by financing activities 648,175us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations 28,437,031us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations
Net change in cash and cash equivalents (13,738,169)us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease 23,052,538us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease
Cash and cash equivalents at beginning of period 23,644,542us-gaap_CashAndCashEquivalentsAtCarryingValue 592,004us-gaap_CashAndCashEquivalentsAtCarryingValue
Cash and cash equivalents at end of period 9,906,373us-gaap_CashAndCashEquivalentsAtCarryingValue 23,644,542us-gaap_CashAndCashEquivalentsAtCarryingValue
Cash paid for:    
Interest 1,983us-gaap_InterestPaid 19,648us-gaap_InterestPaid
NON-CASH TRANSACTIONS    
Issuance of common stock for accrued interest 0opxa_IssuanceOfCommonStockForAccruedInterest 188,543opxa_IssuanceOfCommonStockForAccruedInterest
Conversion of notes payable to common stock 0opxa_ConversionOfNotesPayableToCommonStock 4,275,053opxa_ConversionOfNotesPayableToCommonStock
Discount on convertible notes relating to:    
Warrants 0opxa_DiscountOnConvertibleNotesRelatedToWarrants 195,969opxa_DiscountOnConvertibleNotesRelatedToWarrants
Beneficial conversion feature 0opxa_DiscountOnConvertibleNotesRelatedToBeneficialConversionFeature 141,829opxa_DiscountOnConvertibleNotesRelatedToBeneficialConversionFeature
Unpaid additions to property and equipment 0us-gaap_CapitalExpendituresIncurredButNotYetPaid 108,516us-gaap_CapitalExpendituresIncurredButNotYetPaid
Shares issued as deferred offering costs 0opxa_SharesIssuedAsDeferredOfferingCosts 1,234opxa_SharesIssuedAsDeferredOfferingCosts
Unpaid offering costs $ 0opxa_UnpaidOfferingCosts $ 136,776opxa_UnpaidOfferingCosts