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4. PROPERTY AND EQUIPMENT (Details) (USD $)
12 Months Ended
Dec. 31, 2014
Dec. 31, 2013
Property Plant And Equipment Disclosure [Line Items]    
Property, plant and equipment, gross $ 3,197,493us-gaap_PropertyPlantAndEquipmentGross $ 3,013,501us-gaap_PropertyPlantAndEquipmentGross
Less: accumulated depreciation (2,099,389)us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment (1,718,477)us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment
Property and equipment, net 1,098,104us-gaap_PropertyPlantAndEquipmentNet 1,295,024us-gaap_PropertyPlantAndEquipmentNet
Computer Equipment [Member]    
Property Plant And Equipment Disclosure [Line Items]    
Property, plant and equipment, useful life 3 years  
Property, plant and equipment, gross 168,209us-gaap_PropertyPlantAndEquipmentGross
/ us-gaap_PropertyPlantAndEquipmentByTypeAxis
= us-gaap_ComputerEquipmentMember
121,921us-gaap_PropertyPlantAndEquipmentGross
/ us-gaap_PropertyPlantAndEquipmentByTypeAxis
= us-gaap_ComputerEquipmentMember
Office Furniture And Equipment [Member]    
Property Plant And Equipment Disclosure [Line Items]    
Property, plant and equipment, gross 247,679us-gaap_PropertyPlantAndEquipmentGross
/ us-gaap_PropertyPlantAndEquipmentByTypeAxis
= opxa_OfficeFurnitureAndEquipmentMember
245,297us-gaap_PropertyPlantAndEquipmentGross
/ us-gaap_PropertyPlantAndEquipmentByTypeAxis
= opxa_OfficeFurnitureAndEquipmentMember
Office Furniture And Equipment [Member] | Maximum [Member]    
Property Plant And Equipment Disclosure [Line Items]    
Property, plant and equipment, useful life 7 years  
Office Furniture And Equipment [Member] | Minimum [Member]    
Property Plant And Equipment Disclosure [Line Items]    
Property, plant and equipment, useful life 5 years  
Computer Software Intangible Asset [Member]    
Property Plant And Equipment Disclosure [Line Items]    
Property, plant and equipment, useful life 3 years  
Property, plant and equipment, gross 116,022us-gaap_PropertyPlantAndEquipmentGross
/ us-gaap_PropertyPlantAndEquipmentByTypeAxis
= us-gaap_ComputerSoftwareIntangibleAssetMember
121,378us-gaap_PropertyPlantAndEquipmentGross
/ us-gaap_PropertyPlantAndEquipmentByTypeAxis
= us-gaap_ComputerSoftwareIntangibleAssetMember
Laboratory Equipment [Member]    
Property Plant And Equipment Disclosure [Line Items]    
Property, plant and equipment, useful life 7 years  
Property, plant and equipment, gross 1,100,559us-gaap_PropertyPlantAndEquipmentGross
/ us-gaap_PropertyPlantAndEquipmentByTypeAxis
= opxa_LaboratoryEquipmentMember
1,270,858us-gaap_PropertyPlantAndEquipmentGross
/ us-gaap_PropertyPlantAndEquipmentByTypeAxis
= opxa_LaboratoryEquipmentMember
Leasehold Improvements [Member]    
Property Plant And Equipment Disclosure [Line Items]    
Property, plant and equipment, useful life 10 years  
Property, plant and equipment, gross 675,672us-gaap_PropertyPlantAndEquipmentGross
/ us-gaap_PropertyPlantAndEquipmentByTypeAxis
= us-gaap_LeaseholdImprovementsMember
665,158us-gaap_PropertyPlantAndEquipmentGross
/ us-gaap_PropertyPlantAndEquipmentByTypeAxis
= us-gaap_LeaseholdImprovementsMember
Manufacturing Equipment [Member]    
Property Plant And Equipment Disclosure [Line Items]    
Property, plant and equipment, useful life 7 years  
Property, plant and equipment, gross $ 889,352us-gaap_PropertyPlantAndEquipmentGross
/ us-gaap_PropertyPlantAndEquipmentByTypeAxis
= opxa_ManufacturingEquipmentMember
$ 588,889us-gaap_PropertyPlantAndEquipmentGross
/ us-gaap_PropertyPlantAndEquipmentByTypeAxis
= opxa_ManufacturingEquipmentMember