Consolidated Statements of Changes In Stockholders' Equity (USD $)	11 Months Ended	12 Months Ended										11 Months Ended	12 Months Ended								11 Months Ended	12 Months Ended				11 Months Ended	12 Months Ended																	11 Months Ended	12 Months Ended										11 Months Ended	12 Months Ended																								11 Months Ended	12 Months Ended										11 Months Ended	12 Months Ended								11 Months Ended	12 Months Ended				11 Months Ended	12 Months Ended																					11 Months Ended	12 Months Ended
	Dec. 31, 2003	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009	Dec. 31, 2008	Dec. 31, 2007	Dec. 31, 2006	Dec. 31, 2005	Dec. 31, 2004	Dec. 31, 2003 Cash	Dec. 31, 2013 Cash	Dec. 31, 2012 Cash	Dec. 31, 2011 Cash	Dec. 31, 2009 Cash	Dec. 31, 2008 Cash	Dec. 31, 2006 Cash	Dec. 31, 2005 Cash	Dec. 31, 2004 Cash	Dec. 31, 2003 Beneficial Conversion Feature	Dec. 31, 2013 Beneficial Conversion Feature	Dec. 31, 2012 Beneficial Conversion Feature	Dec. 31, 2005 Beneficial Conversion Feature	Dec. 31, 2004 Beneficial Conversion Feature	Dec. 31, 2003 Warrants Attached to Debt	Dec. 31, 2013 Warrants Attached to Debt	Dec. 31, 2009 Warrants Attached to Debt	Dec. 31, 2005 Warrants Attached to Debt	Dec. 31, 2004 Warrants Attached to Debt	Dec. 31, 2011 Services	Dec. 31, 2010 Services	Dec. 31, 2008 Services	Dec. 31, 2005 Services	Dec. 31, 2004 Services	Dec. 31, 2004 Reverse merger with Sportan	Dec. 31, 2009 Convertible debt	Dec. 31, 2005 Convertible debt	Dec. 31, 2004 Convertible debt	Dec. 31, 2006 Debt	Dec. 31, 2005 Debt	Dec. 31, 2013 Purchase Agreements	Dec. 31, 2012 Purchase Agreements	Dec. 31, 2003 Common Stock	Dec. 31, 2013 Common Stock	Dec. 31, 2010 Common Stock	Dec. 31, 2009 Common Stock	Dec. 31, 2004 Common Stock	Dec. 31, 2012 Common Stock	Dec. 31, 2011 Common Stock	Dec. 31, 2008 Common Stock	Dec. 31, 2007 Common Stock	Dec. 31, 2006 Common Stock	Dec. 31, 2005 Common Stock	Dec. 31, 2003 Common Stock Cash	Dec. 31, 2013 Common Stock Cash	Dec. 31, 2012 Common Stock Cash	Dec. 31, 2011 Common Stock Cash	Dec. 31, 2009 Common Stock Cash	Dec. 31, 2008 Common Stock Cash	Dec. 31, 2006 Common Stock Cash	Dec. 31, 2005 Common Stock Cash	Dec. 31, 2004 Common Stock Cash	Dec. 31, 2011 Common Stock Services	Dec. 31, 2010 Common Stock Services	Dec. 31, 2008 Common Stock Services	Dec. 31, 2005 Common Stock Services	Dec. 31, 2004 Common Stock Services	Dec. 31, 2005 Common Stock Licensing Agreements	Dec. 31, 2004 Common Stock Licensing Agreements	Dec. 31, 2004 Common Stock Reverse merger with Sportan	Dec. 31, 2005 Common Stock Convertible debt	Dec. 31, 2004 Common Stock Convertible debt	Dec. 31, 2006 Common Stock Debt	Dec. 31, 2005 Common Stock Debt	Dec. 31, 2013 Common Stock Purchase Agreements	Dec. 31, 2012 Common Stock Purchase Agreements	Dec. 31, 2013 Common Stock Accrued Interest	Dec. 31, 2012 Common Stock Accrued Interest	Dec. 31, 2003 Additional Paid in Capital	Dec. 31, 2013 Additional Paid in Capital	Dec. 31, 2012 Additional Paid in Capital	Dec. 31, 2011 Additional Paid in Capital	Dec. 31, 2010 Additional Paid in Capital	Dec. 31, 2009 Additional Paid in Capital	Dec. 31, 2008 Additional Paid in Capital	Dec. 31, 2007 Additional Paid in Capital	Dec. 31, 2006 Additional Paid in Capital	Dec. 31, 2005 Additional Paid in Capital	Dec. 31, 2004 Additional Paid in Capital	Dec. 31, 2003 Additional Paid in Capital Cash	Dec. 31, 2013 Additional Paid in Capital Cash	Dec. 31, 2012 Additional Paid in Capital Cash	Dec. 31, 2011 Additional Paid in Capital Cash	Dec. 31, 2009 Additional Paid in Capital Cash	Dec. 31, 2008 Additional Paid in Capital Cash	Dec. 31, 2006 Additional Paid in Capital Cash	Dec. 31, 2005 Additional Paid in Capital Cash	Dec. 31, 2004 Additional Paid in Capital Cash	Dec. 31, 2003 Additional Paid in Capital Beneficial Conversion Feature	Dec. 31, 2013 Additional Paid in Capital Beneficial Conversion Feature	Dec. 31, 2012 Additional Paid in Capital Beneficial Conversion Feature	Dec. 31, 2005 Additional Paid in Capital Beneficial Conversion Feature	Dec. 31, 2004 Additional Paid in Capital Beneficial Conversion Feature	Dec. 31, 2003 Additional Paid in Capital Warrants Attached to Debt	Dec. 31, 2013 Additional Paid in Capital Warrants Attached to Debt	Dec. 31, 2009 Additional Paid in Capital Warrants Attached to Debt	Dec. 31, 2005 Additional Paid in Capital Warrants Attached to Debt	Dec. 31, 2004 Additional Paid in Capital Warrants Attached to Debt	Dec. 31, 2011 Additional Paid in Capital Services	Dec. 31, 2010 Additional Paid in Capital Services	Dec. 31, 2008 Additional Paid in Capital Services	Dec. 31, 2005 Additional Paid in Capital Services	Dec. 31, 2004 Additional Paid in Capital Services	Dec. 31, 2005 Additional Paid in Capital Licensing Agreements	Dec. 31, 2004 Additional Paid in Capital Licensing Agreements	Dec. 31, 2004 Additional Paid in Capital Reverse merger with Sportan	Dec. 31, 2009 Additional Paid in Capital Convertible debt	Dec. 31, 2005 Additional Paid in Capital Convertible debt	Dec. 31, 2004 Additional Paid in Capital Convertible debt	Dec. 31, 2006 Additional Paid in Capital Debt	Dec. 31, 2005 Additional Paid in Capital Debt	Dec. 31, 2013 Additional Paid in Capital Purchase Agreements	Dec. 31, 2012 Additional Paid in Capital Purchase Agreements	Dec. 31, 2013 Additional Paid in Capital Accrued Interest	Dec. 31, 2012 Additional Paid in Capital Accrued Interest	Dec. 31, 2003 Accumulated Deficit	Dec. 31, 2013 Accumulated Deficit	Dec. 31, 2012 Accumulated Deficit	Dec. 31, 2011 Accumulated Deficit	Dec. 31, 2010 Accumulated Deficit	Dec. 31, 2009 Accumulated Deficit	Dec. 31, 2008 Accumulated Deficit	Dec. 31, 2007 Accumulated Deficit	Dec. 31, 2006 Accumulated Deficit	Dec. 31, 2005 Accumulated Deficit	Dec. 31, 2004 Accumulated Deficit
Cumulative effect of change in accounting principle						$ (220,835)																																																																															$ (1,976,457)																																															$ 1,755,622
Conversion of convertible notes (in shares)																																													2,079,960	690,045		15,187
Conversion of convertible notes		4,275,053			1,380,091						248,370																																		20,799	6,900		7,594																																	4,254,254			1,373,191						240,776
Par value adjustment																																															(1,500,117)																																						1,500,117
Change in derivative liability			1,761,657			587,609		6,656,676																																																																										1,761,657			587,609		10,658,496																																															(4,001,820)
Discount related to:
Discount																					28,180	141,829	1,497,634	831,944	855,849	28,180	195,969	37,453	1,433,108	1,848,502							439,493																																																															28,180	141,829	1,497,634	831,944	855,849	28,180	195,969	37,453	1,433,108	1,848,502									439,493
Shares issued for:
Exercise of options (in shares)					35,380	15,100																																								35,380	15,100
Exercise of options					109,641	63,604																																								354	151																																					109,287	63,453
Acquisition of Opexa (in shares)																																																62,500
Acquisition of Opexa											23,750,000																																					31,250																																										23,718,750
Exercise of warrants (shares)																																														8,500	154,991
Shares issued (in shares)																																																							131,250	19,013,952	267,610	1,132,726	637,500	1,375,968	1,150,000	97,362	562	12,576	13,750	11,300	6,000	51,625	7,298	6,067	24,934	152,756	4,025	8,707	575	975	56,507	123,231	163,224
Shares issued												1,000	28,348,100	333,970	8,618,157	4,689,165	8,651,579	21,153,519	5,346,217	9,000											87,028	64,350	48,965	1,012,400	849,000	(147,733)		7,649,446	288,366	180,000	161,000	1,234	149,131												65,625	190,140	2,676	11,328	6,375	687,984	575,000	48,681	281	126	138	5,650	3,000	25,813	3,649	3,033	12,467	76,378	2,012	4,354	288	10	565	1,232	1,632												(64,625)	28,157,960	331,294	8,606,829	4,682,790	7,963,595	20,578,519	5,297,536	8,719											86,902	64,212	43,315	1,009,400	823,187	1,864,735	424,042	(160,200)		7,573,068	286,354	175,646	160,712	1,224	148,566	187,311	184,051
Exercise of warrants						1,074,935																																								85	1,550																																					(85)	1,073,385
Restricted stock awards (in shares)																																													78,571
Restricted stock awards		69,899																																											786																																				69,113
Warrant expense		219,553						845,275	1,568,966	2,373,888																																																																							219,553						845,275	1,568,966	2,373,888
Shares repurchased and cancelled (in shares)																																												(42,656)
Issuance of warrants for cash							603,850																																																																															603,850
Shares cancelled (in shares)																																																(2,000)
Shares cancelled																																																(1,000)																																										1,000
Shares repurchased and cancelled	(325)																																											(21,328)																																				21,003
Stock-based compensation expense		910,087	690,726	489,914	508,550	650,249	1,901,570	1,876,103	2,749,617	2,487,741	123,333																																																																						910,087	690,726	489,914	508,550	650,249	1,901,570	1,876,103	2,749,617	2,487,741	123,333
Transition of warrants from equity instruments to liability instruments										(10,658,496)																																																																															(10,658,496)
Net loss	(126,003)	(16,656,325)	(8,930,833)	(5,968,448)	(5,469,067)	(1,433,922)	(11,852,152)	(14,667,367)	(12,649,170)	(14,856,724)	(31,411,736)																																																																																																																				(126,003)	(16,656,325)	(8,930,833)	(5,968,448)	(5,469,067)	(1,433,922)	(11,852,152)	(14,667,367)	(12,649,170)	(14,856,724)	(31,411,736)
Ending Balances (in shares)																																												88,594	27,546,058	4,616,726	3,869,051	251,494	6,249,369	5,762,028	3,061,460	1,674,192	1,674,192	515,485
Ending Balances	$ (68,968)	$ 20,577,274	$ 2,883,332	$ 7,195,364	$ 3,968,713	$ 7,375,148	$ 1,487,397	$ 2,133,585	$ 7,422,898	$ (5,580,034)	$ (3,228,942)																																	$ 44,297	$ 275,461	$ 46,167	$ 38,690	$ 125,747	$ 62,494	$ 57,621	$ 1,530,731	$ 837,097	$ 837,097	$ 257,743																										$ 12,738	$ 146,569,758	$ 112,432,458	$ 107,818,530	$ 98,634,885	$ 96,579,730	$ 89,521,638	$ 79,009,308	$ 65,629,434	$ 40,556,686	$ 28,183,050																																					$ (126,003)	$ (126,267,945)	$ (109,611,620)	$ (100,680,787)	$ (94,712,339)	$ (89,243,272)	$ (89,564,972)	$ (77,712,820)	$ (59,043,633)	$ (46,394,463)	$ (31,537,739)