<?xml version="1.0" encoding="us-ascii"?><InstanceReport xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><Version>2.4.0.8</Version><ReportLongName>110 - Disclosure - Significant Accounting Polices</ReportLongName><DisplayLabelColumn>true</DisplayLabelColumn><ShowElementNames>false</ShowElementNames><RoundingOption /><HasEmbeddedReports>false</HasEmbeddedReports><Columns><Column FlagID="0"><Id>1</Id><IsAbstractGroupTitle>false</IsAbstractGroupTitle><LabelSeparator>

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</LabelSeparator><Level>4</Level><ElementName>us-gaap_SignificantAccountingPoliciesTextBlock</ElementName><ElementPrefix>us-gaap_</ElementPrefix><IsBaseElement>true</IsBaseElement><BalanceType>na</BalanceType><PeriodType>duration</PeriodType><IsReportTitle>false</IsReportTitle><IsSegmentTitle>false</IsSegmentTitle><IsCalendarTitle>false</IsCalendarTitle><IsEquityPrevioslyReportedAsRow>false</IsEquityPrevioslyReportedAsRow><IsEquityAdjustmentRow>false</IsEquityAdjustmentRow><IsBeginningBalance>false</IsBeginningBalance><IsEndingBalance>false</IsEndingBalance><IsReverseSign>false</IsReverseSign><PreferredLabelRole>terseLabel</PreferredLabelRole><FootnoteIndexer /><Cells><Cell FlagID="0" ContextID="eol_PE10315---1310-Q0011_STD_181_20130630_0" UnitID=""><Id>1</Id><IsNumeric>false</IsNumeric><IsRatio>false</IsRatio><DisplayZeroAsNone>false</DisplayZeroAsNone><NumericAmount>0</NumericAmount><RoundedNumericAmount>0</RoundedNumericAmount><NonNumbericText>&lt;div style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"&gt;
&lt;div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"&gt;&lt;font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold"&gt;
Note 2.&amp;#xA0;&amp;#xA0;Significant Accounting Polices&lt;/font&gt;&lt;/div&gt;
&lt;div style="TEXT-INDENT: 0pt; DISPLAY: block"&gt;&lt;br /&gt;&lt;/div&gt;
&lt;div style="TEXT-INDENT: 18pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"&gt;&lt;font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"&gt;&lt;font style="DISPLAY: inline; FONT-WEIGHT: bold"&gt;
Revenue Recognition.&lt;/font&gt;&amp;#xA0;&amp;#xA0;Opexa recognizes revenue in
accordance with FASB ASC 605, Revenue Recognition. ASC 605 requires
that four basic criteria must be met before revenue can be
recognized: (1) persuasive evidence of an arrangement exists; (2)
delivery has occurred or services rendered; (3) consideration is
fixed or determinable; and (4) collectability is reasonably
assured.&lt;/font&gt;&lt;/div&gt;
&lt;div style="TEXT-INDENT: 0pt; DISPLAY: block"&gt;&lt;br /&gt;&lt;/div&gt;
&lt;div style="TEXT-INDENT: 18pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"&gt;&lt;font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"&gt;On
February 4, 2013, Opexa entered into an Option and License
Agreement (the &amp;#x201C;Merck Agreement&amp;#x201D;) with Ares Trading SA
(&amp;#x201C;Merck&amp;#x201D;), a wholly owned subsidiary of Merck Serono
S.A.&amp;#xA0;&amp;#xA0;Pursuant to the terms, Merck has an option to
acquire an exclusive, worldwide (excluding Japan) license of the
Company&amp;#x2019;s Tcelna&lt;font style="DISPLAY: inline; FONT-SIZE: 70%; VERTICAL-ALIGN: text-top"&gt;&amp;#xAE;&lt;/font&gt;
program for the treatment of multiple sclerosis
(&amp;#x201C;MS&amp;#x201D;).&amp;#xA0;&amp;#xA0;Tcelna is currently in a Phase IIb
clinical trial in patients with Secondary Progressive MS
(&amp;#x201C;SPMS&amp;#x201D;). The option may be exercised by Merck prior to
or upon the Company&amp;#x2019;s completion of the Phase IIb
Trial.&lt;/font&gt;&lt;/div&gt;
&lt;div style="TEXT-INDENT: 0pt; DISPLAY: block"&gt;&lt;br /&gt;&lt;/div&gt;
&lt;div style="TEXT-INDENT: 18pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"&gt;&lt;font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"&gt;Opexa
received an upfront payment of $5 million for granting the option.
If the option is exercised, Merck would pay the Company an upfront
license fee of $25 million unless Merck is unable to advance
directly into a Phase III clinical trial of Tcelna for SPMS without
a further Phase II clinical trial (as determined by Merck), in
which event the upfront license fee would be $15 million. After
exercising the option, Merck would be solely responsible for
funding development, regulatory and commercialization activities
for Tcelna in MS, although the Company would retain an option to
co-fund certain development in exchange for increased royalty
rates.&amp;#xA0;&amp;#xA0;The Company would also retain rights to Tcelna in
Japan, certain rights with respect to the manufacture of Tcelna,
and rights outside of MS.&lt;/font&gt;&lt;/div&gt;
&lt;div style="TEXT-INDENT: 0pt; DISPLAY: block"&gt;&lt;br /&gt;&lt;/div&gt;
&lt;div style="TEXT-INDENT: 18pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"&gt;&lt;font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"&gt;Opexa
evaluated the Merck Agreement and determined that the $5 million
upfront payment from Merck has stand-alone value. Opexa&amp;#x2019;s
continuing performance obligations, in connection with the $5
million payment, include the execution and completion of the Phase
IIb clinical trial in SPMS using commercially reasonable efforts at
the Company&amp;#x2019;s own costs.&amp;#xA0;&amp;#xA0;As a stand-alone value
term in the Merck Agreement, the $5 million upfront payment is
determined to be a single unit of accounting, and is recognized as
revenue on a straight-line basis over the exclusive option period
based on the expected completion term of the Phase IIb clinical
trial in SPMS. Opexa includes the unrecognized portion of the $5
million as deferred revenue on the consolidated balance
sheets.&lt;/font&gt;&lt;/div&gt;
&lt;div style="TEXT-INDENT: 0pt; DISPLAY: block"&gt;&lt;br /&gt;&lt;/div&gt;
&lt;div style="TEXT-INDENT: 18pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"&gt;&lt;font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"&gt;&lt;font style="DISPLAY: inline; FONT-WEIGHT: bold"&gt;
Cash and Cash Equivalents&lt;/font&gt;.&amp;#xA0;&amp;#xA0;Opexa considers all
highly liquid investments with an original maturity of three months
or less, when purchased, to be cash equivalents. Investments with
maturities in excess of three months but less than one year are
classified as short-term investments and are stated at fair market
value.&lt;/font&gt;&lt;/div&gt;
&lt;div style="TEXT-INDENT: 0pt; DISPLAY: block"&gt;&lt;br /&gt;&lt;/div&gt;
&lt;div style="TEXT-INDENT: 18pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"&gt;&lt;font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"&gt;Opexa
primarily maintains cash balances on deposit in accounts at a
U.S.-based financial institution.&amp;#xA0;&amp;#xA0;The aggregate cash
balance on deposit in these accounts is insured by the Federal
Deposit Insurance Corporation up to
$250,000.&amp;#xA0;&amp;#xA0;Opexa&amp;#x2019;s cash balances on deposit in
these accounts may, at times, exceed the federally insured
limits.&amp;#xA0;&amp;#xA0;Opexa has not experienced any losses in such
accounts.&lt;/font&gt;&lt;/div&gt;
&lt;div style="TEXT-INDENT: 18pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"&gt;&amp;#xA0;&lt;/div&gt;
&lt;div style="TEXT-INDENT: 18pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"&gt;&lt;font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"&gt;At
June 30, 2013, Opexa invested approximately $4.7 million in a
savings account.&amp;#xA0;&amp;#xA0;For the six months ended June 30, 2013,
the savings account recognized an average market yield of
0.23%.&amp;#xA0;&amp;#xA0;Interest income of $4,940 was recognized for the
six months ended June 30, 2013 in the consolidated statements of
operations.&lt;/font&gt;&lt;/div&gt;
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