Exhibit 32.2

                CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350,
                       AS ADOPTED PURSUANT TO SECTION 906
                        OF THE SARBANES-OXLEY ACT OF 2002

Pursuant to 18 U.S.C. Section 1350, the undersigned Officer of PharmaFrontiers
Corp. (the "Company"), hereby certifies, to such officer's knowledge, that the
Company's Annual Report on Form 10-KSB for the year ended December 31, 2004 (the
"Report") fully complies with the requirements of Section 13(a) or Section
15(d), as applicable, of the Securities Exchange Act of 1934 and that the
information contained in the Report fairly presents, in all material respects,
the financial condition and results of operations of the Company.



/s/ C. WILLIAM ROUSE
--------------------
C. William Rouse
Chief Financial Officer and Principal Accounting Officer


Date: April 14, 2005


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