X0306 4 2013-02-04 0 0001069308 Opexa Therapeutics, Inc. OPXA 0001395070 Rill Donna R C/O OPEXA THERAPEUTICS, INC. 2635 TECHNOLOGY FOREST BLVD. THE WOODLANDS TX 77381 0 1 0 0 Chief Development Officer Common Stock 2013-04-29 4 A 0 20000 0 A 20402 D Employee Stock Option (right to buy) 3.80 2013-02-04 4 A 0 20939 0 A 2022-01-06 Common Stock 20939 20939 D Employee Stock Option (right to buy) 1.75 2013-04-29 4 A 0 20000 0 A 2023-04-29 Common Stock 20000 20000 D Adjusted to reflect the issuer's 1-for-4 reverse stock split that was implemented December 14, 2012, resulting in the reporting person owning 402 shares of common stock prior to the transaction reported herein On January 6, 2012, the reporting person was granted an option to purchase 31,408 shares of common stock at the closing market price. The option is performance based and begins to vest quarterly over a three-year period in two tranches commencing upon Opexa achieving certain key milestones. The second tranche key milestone for vesting of 20,939 shares is Opexa entering into a collaboration, partnership or other strategic arrangement involving US rights for Tcelna. The performance criteria for the second key milestone was met on February 4, 2013 and vesting has commenced for the second tranche of 20,939 shares. All share numbers and the exercise price have been adjusted to reflect the one-for-four reverse stock split implemented December 14, 2012. Quarterly vesting on the anniversary date of the grant over three years. /s/ Donna R. Rill 2013-05-01