X0306 4 2013-02-12 0 0001069308 Opexa Therapeutics, Inc. OPXA 0001359850 Seaman Scott B C/O OPEXA THERAPEUTICS, INC. 2635 TECHNOLOGY FOREST BLVD. THE WOODLANDS TX 77381 1 0 0 0 Common Stock Warrant (Right to Buy) 8 2013-02-12 4 S 0 25 0.015 D 2008-02-19 2013-02-19 Common Stock 50000 49975 I See Note Common Stock Warrant (Right to Buy) 8 2013-02-13 4 S 0 36691 0.0075 D 2008-02-19 2013-02-19 Common Stock 49975 13284 I See Note Common Stock Warrant (Right to Buy) 8 2013-02-14 4 S 0 11966 0.0075 D 2008-02-19 2013-02-19 Common Stock 13284 1318 I See Note Common Stock Warrant (Right to Buy) 8 2013-02-19 4 S 0 1318 0.0075 D 2008-02-19 2013-02-19 Common Stock 1318 0 I See Note Common Stock Warrant (Right to Buy) 8 2008-02-19 2013-02-19 Common Stock 2500 2500 D Held by Alkek & Williams Ventures, Ltd. ("Ventures"). Chaswil, Ltd. ("Chaswil") is the investment manager of Ventures and holds voting power and investment power with respect to the Issuer securities held by Ventures. Mr. Seaman is a registered principal of Chaswil and has shared voting power and/or investment power with respect to the Issuer securities held by Ventures. Mr. Seaman disclaims beneficial ownership of the shares held by Ventures except to the extent of any pecuniary interest therein. Adjusted to reflect the issuer's 1-for-4 reverse stock split that was implemented December 14, 2012, resulting in Ventures owning 50,000 Series E Warrants at an exercise price of $8.00 prior to the transactions reported herein. Adjusted to reflect the issuer's 1-for-4 reverse stock split that was implemented December 14, 2012. /s/ John Ginzler, by Power of Attorney 2013-02-19