X0306 4 2012-12-31 0 0001069308 Opexa Therapeutics, Inc. OPXA 0001359850 Seaman Scott B C/O OPEXA THERAPEUTICS, INC. 2635 TECHNOLOGY FOREST BLVD. THE WOODLANDS TX 77381 1 0 0 0 Common Stock 2012-12-31 4 A 0 19978 1.33 A 230181 I See footnote Common Stock 10913 D On December 31, 2012, 19,978 shares of Common Stock were issued to Alkek & Williams Ventures Ltd ("Ventures") as payment-in-kind for interest accrued as of December 31, 2012 on a 12% Convertible Secured Promissory Note held by Ventures in the principal amount of $500,000. The shares issued in payment of accrued interest payable on the interest payment date were deemed to have a value equal to the volume weighted average price for the Common Stock for the five trading days ending three trading days prior to the payment date. Adjusted to reflect the issuer's 1-for-4 reverse stock split that was implemented December 14, 2012, resulting in Ventures owning 210,203 shares of common stock prior to the transaction reported herein. Held by Ventures. Chaswil, Ltd. ("Chaswil") is the investment manager of Ventures and holds voting power and investment power with respect to the Issuer securities held by Ventures. Mr. Seaman is a registered principal of Chaswil and has shared voting power and/or investment power with respect to the Issuer securities held by Ventures. Adjusted to reflect the issuer's 1-for-4 reverse stock split that was implemented December 14, 2012 /s/ John Ginzler, by Power of Attorney 2013-01-24